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| 1 | Liver pathology of hepatitis C,beyond grading and stagingof the disease显示文摘Liver biopsy evaluation plays a critical role in management of patients with viral hepatitis C. In patients with acute viral hepatitis, a liver biopsy, though uncommonly performed, helps to rule out other nonviral causes of deranged liver function. In chronic viral hepatitis C, it is considered the gold standard in assessment of the degree of necroinflammation and the stage of fibrosis, to help guide treatment and determine prognosis. It also helps rule out any concomitant diseases such as steatohepatitis, hemochromatosis or others. In patients with chronic progressive liver disease with cirrhosis and dominant nodules, a targeted liver biopsy is helpful in differentiating a regenerative nodule from dysplastic nodule or hepatocellular carcinoma. In the setting of transplantation, the liver biopsy helps distinguish recurrent hepatitis C from acute rejection and also is invaluable in the diagnosis of fibrosing cholestatic hepatitis, a rare variant of recurrent hepatitis C. This comprehensive review discusses the entire spectrum of pathologic findings in the course of hepatitis C infection. | Sadhna Dhingra Stephen C Ward Swan N Thung | 2016 | World Journal of Gastroenterology2016，22，4： | 6 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves Certain aspects of meat quality in Stress-Genotype pigs显示文摘 | Wiegand B R Parrish F C Swan Jr J E | 2001 | J Anim Sci2001，79，： | 1 |
| 4 | Identification of novel polymorphisms within the promoter region of the human β2 adrenergic receptor gene显示文摘 | Scott MG Swan C Wheatley AP | 1999 | Br J Pharmacol1999，126，： | 1 |
| 5 | Quality control of laboratory methods for semen evaluation in a multicenter research study显示文摘 | Brazil C Swan SH Tollner CR | 2004 | J Androl2004，25，4： | 1 |
| 6 | Insulin in CHF: relation to severity and etiology of heaet failure显示文摘 | Swan JW Anker SD Walton C | 1997 | J Am Coll Cardiol1997，30，2： | 1 |
| 7 | Extreme ocean waves--part I: the practical application of fully nonlinear wave modeling显示文摘 | Bateman W J D Katsardi V Swan C | 2012 | Applied Ocean Research2012，34，： | 1 |
| 8 | A symmetry reduction methodfor continuum structural topology optimization显示文摘 | Kosaka I Swan C C | 1999 | Computers and Structures1999，70，： | 1 |
| 9 | Limit state analysis of earthen slopes using dual continuum/FEM approaches显示文摘 | SWAN C C SEO Y K | 1999 | International Journal for Numerical and Analytical Methods in Geomechanics1999，23，12： | 1 |
| 10 | Role of programmed cell death in the immunopathogenesis of sepsis显示文摘 | PERL M CHUNG C S SWAN R | 2007 | Drug Discov Today Dis Mech2007，4，4： | 1 |
| 11 | Human papillomavirus(HPV) DNA copy number is dependent on grade of cervical disease and HPV type显示文摘 | Swan D C Tucker R A Tortolero-Luna G | 1999 | J Clin Microbiol1999，37，： | 1 |
| 12 | Human Papillomavirus (HPV) DNA Copy Number is Dependent on Grade of Cervical Disease and HPV Type显示文摘 | David C Swan Ruth Ann Tucker | 1999 | J Clin Microbio1999，37，4： | 1 |
| 13 | Social physique anxiety in postmenopausal women显示文摘 | Ransdell L B Wells C L Manore M M Swan P D & Corbin C | 1998 | Journal of Women & Aging1998，10，： | 1 |
| 14 | CMT1X phenotypes represent loss of GJB1 gene function 显示文摘 | Shy ME Siskind C Swan ER | 2007 | Neurology2007，68，： | 1 |
| 15 | Voxel-based meshing and unit-cellanalysis of textile composites显示文摘 | KIM H J SWAN C C | 2003 | International Journal forNumerical Methods in Engineering2003，56，7： | 1 |
| 16 | Origin of the characteristic elec- tron energy losses in magnesium显示文摘 | Powell C J Swan J B | 1959 | Phys Rev1959，116，1： | 1 |
| 17 | Debris Management Planning for the 21st Century显示文摘 | Swan R C | 2000 | Natural Hazards Review2000，1，4： | 1 |
| 18 | Quality control of laboratory methods for semen evaluation in a multicenter research study 显示文摘 | Brazil C Swan SH Tollner CR | 2004 | J Androl2004，25，4： | 1 |
| 19 | Limit state analysis of earthen slopes using dual continuum/FEM approaches 显示文摘 | SEO Y K SWAN C C | 1999 | International Journal of Numerical Analysis Method in Geotechnical1999，，23： | 1 |
| 20 | Phys显示文摘 | Powell C J Swan J B | 1959 | Rev1959，115，： | 1 |
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