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| 1 | Advances on strategies for searching for next generation thermal barrier coating materials显示文摘Thermal barrier coating(TBC) materials play important roles in gas turbine engines to protect the Nibased super-alloys from the high temperature airflow damage. High melting point, ultra-low thermal conductivity, large thermal expansion coefficient, excellent damage tolerance and moderate mechanical properties are the main requirements of promising TBC materials. In order to improve the efficiency of jet and/or gas turbine engines, which is the key of improved thrust-to-weight ratios and the energysaving, significant efforts have been made on searching for enhanced TBC materials. Theoretically, density functional theory has been successfully used in scanning the structure and properties of materials, and at the same time predicting the mechanical and thermal properties of promising TBC materials for high and ultrahigh temperature applications, which are validated by subsequent experiments. Experimentally,doping and/or alloying are also widely applied to further decrease their thermal conductivities. Now, the strategy through combining theoretical calculations and experiments on searching for next generation thermal insulator materials is widely adopted. In this review, the common used techniques and the recent advantages on searching for promising TBC materials in both theory and experiments are summarized. | Bin Liu Yuchen Liu Changhua Zhu Huimin Xiang Hongfei Chen Luchao Sun Yanfeng Gao Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，5： | 24 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Direct low-temperature synthesis of graphene on various glasses by plasma-enhanced chemical vapor deposition for versatile, cost-effective electrodes显示文摘在低温度的各种各样的玻璃底层上的 graphene 的没有催化剂、可伸缩的合成具有到象便宜透明电子学和最先进的显示器那样的众多的应用程序的首要的意义。然而,在这个有希望的研究领域以内的系统的学习远这样仍然保持少见。此处,我们用一个低温度的提高血浆的化学蒸汽免职方法在各种各样的眼镜上报导 graphene 的直接生长。如此的一条灵巧、可伸缩的途径在 400600 的一个生长温度范围在各种各样的玻璃底层上保证一致、没有转移的 graphene | Jingyu Sun Yubin Chen Xin Cai Bangjun Ma Zhaolong Chen Manish Kr. Priydarshi Ke Chen Teng Gao Xiuju Song Qingqing Ji Xuefeng Guo Dechun Zou Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，11： | 12 |
| 4 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 5 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 6 | Designing N-doped graphene/ReSe_(2)/Ti_(3)C_(2) MXene heterostructure frameworks as promising anodes for high-rate potassium-ion batteries显示文摘Developing high-performance anodes for potassium ion batteries(KIBs) is of paramount significance but remains challenging.In the normal sense,electrode materials are prepared by ubiquitous wet chemical routes,which otherwise might not be versatile enough to create desired heterostructures and/or form clean interfacial areas for fast transport of K-ions and electrons.Along this line,rate capability/cycling stability of resulting KIBs are greatly handicapped.Herein we present an all-chemical vapor deposition approach to harness the direct synthesis of nitrogen-doped graphene(NG)/rhenium diselenide(ReSe_2)hybrids over three-dimensional MXene supports as superior heterostructure anode material for KIBs.In such an innovative design,1 T'-ReSe2 nanoparticles are sandwiched in between the NG coatings and MXene frameworks via strong interfacial interactions,thereby affording facile K~+ diffusion,enhancing overall conductivity,boosting high-power performance and reinforcing structural stability of electrodes.Thus-constructed anode delivers an excellent rate performance of 138 mAh g^(-1) at 10.0 A g^(-1) and a high reversible capacity of 90 mAh g^(-1) at 5 A g^(-1) after 300 cycles.Furthermore,the potassium storage mechanism has been systematically probed by advanced in situlex situ characterization techniques in combination with first principles computations. | Zhou Xia Xiwen Chen Haina Cia Zhaodi Fan Yuyang Yi Wanjian Yin Nan Wei Jingsheng Cai Yanfeng Zhang Jingyu Sun | 2021 | Journal of Energy Chemistry2021，30，2： | 9 |
| 7 | Polymer-coated nanoporous carbons for trace seawater uranium adsorption显示文摘Polymer-coated mesoporous carbon nanocomposites were prepared from the immobilization of acrylonitrile and acrylic acid copolymers with divinylbenzene as a crosslinker onto a mesoporous carbon framework.High surface areas were maintained after polymerization with accessible porosity.This functional nanocomposite was tested as an adsorbent for uranium from high salinity solutions.Uranium adsorption results have shown that the adsorption capacities are strongly influenced by the density of the amidoxime groups and the specific surface area. | YUE YanFeng SUN XiaoGuang MAYES Richard T. KIM Jungseung FULVIO Pasquale F. QIAO ZhenAn BROWN Suree TSOURIS Costas OYOLA Yatsandra DAI Sheng | 2013 | Science China Chemistry2013，56，11： | 9 |
| 8 | Structural Characteristics and Formation Mechanism in the Micangshan Foreland,South China显示文摘躺在 Dabashan, Longmenshan 和 Qinling 山的连接, Micangshan Orogenic 带结合了盆是双结构和背戳有很少水平排水量,小戳差错和连续沉积盖子的三角形的带。根据 3D 地震数据,并且通过沉积、结构的研究, Micangshan 低岬能被划分成五条潜水艇带,它从北方到向南:地下室推进的、正面的戳,低岬 depression-back-thrust 三角,低岬褶层带或背斜带,和 Tongjiang 消沉。沿着到东方的从西方的罢工的方向, Micangshan 的弓形的结构的带能被划分成西方,中间和东方片断。在在 Qinling 和 Yangtze 盘子之间的碰撞期间, Micangshan Orogenic 带受到三个僵硬岩层的相互作用:Bikou, Foping,和 Fenghuangshan (又名 Ziyang ) 岩层。僵硬岩层的碰撞进程控制了 Micangshan 低岬的结构的开发,它是:(a) 在形成结构的更早的基础的 Micangshan-Hannan 和 Bikou 岩层之间的以前的碰撞;并且(b) 形成结构的带的主要身体的以后的碰撞。Micangshan Orogenic 带的形成过程能被划分成四个阶段:(1 ) 在 Indosinian 运动的早阶段, Micangshan-Hannan 僵硬岩层被连接到 Qinling 板由顺时针方向向 Qinling 板的 Yangtze 板的 subduction;(2 ) 自从晚三叠纪, Tongnanba 和 Jiulongshan 背斜的更早的基础和相应向斜被压缩从 Bikou, Foping 和 Micangshan-Hannan 的不同方向形成岩层;(3 ) 在喜玛拉雅的运动的早阶段, Micangshan-Hannan 岩层形成了 Micangshan 越过水坝落下的水岩山病房低岬盆和压缩压力主要沿着两它的胁腹被集中,而 Micangshan-Hannan 岩层挤了进 Qinling Orogenic,与力量系上带子;(4 ) 在喜玛拉雅的运动的迟了的阶段, Qinling 板的主要碰撞做了岩层的旧地下室岩石快速高举,形成 Micangshan Orogenic 带。Micangshan 低岬弓形的结构由于岩层的非同质被形成运动。 | XU Huaming LIU Shu QU Guosheng LI Yanfeng SUN Gang LIU Kang | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 8 |
| 9 | The role of climate factors in geographic variation in body mass and wing length in a passerine bird显示文摘Background: Geographic variation in body size is assumed to reflect adaptation to local environmental conditions. Although Bergmann's rule is usually sufficient to explain such variation in homeotherms, some exceptions have been documented. The relationship between altitude, latitude and body size, has been well documented for some vertebrate taxa during the past decades. However, relatively little information is available on the effects of climate variables on body size in birds.Methods: We collected the data of 267 adult Eurasian Tree Sparrow(Passer montanus) specimens sampled at 48 localities in China's mainland, and further investigated the relationships between two response variables, body mass and wing length, as well as a suit of explanatory variables, i.e. altitude, latitude, mean annual temperature(MAT), annual precipitation(PRC), annual sunshine hours(SUN), average annual wind speed(WS), air pressure(AP) and relative humidity(RH).Results: Our study showed that(1) although the sexes did not differ significantly in body mass, males had longer wings than females;(2) body mass and wing length were positively correlated with altitude but not with latitude;(3) body mass and wing length were negatively correlated with AP and RH, but not significantly correlated with WS. Body mass was positively correlated with SUN and inversely correlated with MAT. Wing length was not correlated with MAT in either sex, but was positively correlated with SUN and negatively correlated with PRC in male sparrows;(4) variation in body mass could be best explained by AP and SUN, whereas variation in wing length could be explained by RH and AP in both sexes. In addition, variation in male sparrows can be explained by SUN, WS and PRC but not in females.Conclusions: Two different proxies of body size, body mass and wing length, correlated with same geographic factors and different climate factors. These differences may reflect selection for heat conservation in the case of body mass, and for efficient flight in the case of wing length. | Yanfeng Sun Mo Li Gang Song Fumin Lei Dongming Li Yuefeng Wu | 2017 | Chinese Birds2017，，1： | 7 |
| 10 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 11 | Heterostructured graphene quantum dot/WSe2/Si photo-detector with suppressed dark current and improved detectivity显示文摘 | Mengxing Sun Qiyi Fang Dan Xie Yilin Sun Liu Qian Jianlong Xu Peng Xiao Changjiu Teng Weiwei Li Tianling Ren Yanfeng Zhang | 2018 | Nano Research2018，11，6： | 5 |
| 12 | Effects of capture and captivity on plasma corticosterone and metabolite levels in breeding Eurasian Tree Sparrows显示文摘Background: Bringing free-living animals into captivity subjects them to the stress of both capture and captivity, leading to the alteration of normal physiological processes and behaviors through activation of the hypothalamic– pituitary–adrenal axis. In free-living birds, although elevated plasma corticosterone (CORT) is an important adaptation regulating physiological and behavioral responses during the process of capture and captivity stress, little information is currently available on the effects of such stress on plasma metabolite levels. Methods: We examined the effects of immediate capture and 24-h captivity on body mass, body condition, plasma CORT, and metabolite levels including glucose (Glu), triglyceride (TG), total cholesterol (TC), uric acid (UA), in breeding Eurasian Tree Sparrows (Passer montanus). Results: CORT and Glu levels were increased significantly by the stress of capture, whereas TC and UA levels decreased. Body mass, body condition declined notably after 24 h in captivity, but CORT, Glu, and UA levels increased. Furthermore, male sparrows had lower TG levels after both capture and captivity than those of females. The relationships between plasma CORT and metabolite levels varied between sexes. Conclusions: Our results revealed that the metabolic status of Eurasian Tree Sparrows could be dramatically altered by capture and captivity. Monitoring the dynamic effects of both capture and captivity on plasma CORT, metabolite levels in a free-living bird contributes to a better understanding of the stress-induced pathways involved in sexdependent energy mobilization. | Mo Li Weiwei Zhu Yang Wang Yanfeng Sun Juyong Li Xuelu Liu Yuefeng Wu Xuebin Gao Dongming Li | 2019 | Avian Research2019，10，2： | 5 |
| 13 | Fast and uniform growth of graphene glass using confined-flow chemical vapor deposition and its unique applications显示文摘常规玻璃上的高质量的 graphene 的快、一致的生长为 graphene 玻璃的实际应用程序是很重要的。我们此处为 graphene 玻璃的高效率的制造报导一条范围流动化学药品蒸汽免职(CVD ) 途径。我们的途径的特色是 2-4 m 的制造在玻璃底层上面的宽差距,与很多的跌倒块;这差距被发现显著地增加在对方之间并且与玻璃表面的碳先锋和反应碎片的碰撞概率。作为结果, graphene 玻璃的生长率显著地增加了,和在象与那些相比的生长质量和在常规煤气的流动 CVD 技术的一致性的改进。这些高质量的 graphene 眼镜与以前报导的那些相比以许多更高的 defogging 速度和更高的稳定性展出了优秀 defogging 表演。graphene 蓝宝石玻璃被发现是为种制服和极端光滑的铝氮化物的理想的底层没有缓冲区层的乏味的免职前的薄电影。介绍范围流动 CVD 途径为 graphene 玻璃的大量生产提供一条简单、便宜的线路,它被相信支持各种各样的 graphene 眼镜的实际应用。 | Zhaolong Chen Baolu Guan Xu-dong Chen Qing Zeng Li Lin Ruoyu Wang Manish Kr. Priydarshi Jingyu Sun Zhepeng Zhang Tongbo Wei Jinmin LI Yanfeng Zhang Yingying Zhang Zhongfan Liu | 2016 | Nano Research2016，9，10： | 5 |
| 14 | Blocking of the PD-1/PD-L1 interaction by a novel cyclic peptide inhibitor for cancer immunotherapy显示文摘The interaction of PD-1/PD-L1 allows tumor cells to escape from immune surveillance.Clinical success of the antibody drugs has proven that blockade of PD-1/PD-L1 pathway is a promising strategy for cancer immunotherapy.Here,we developed a cyclic peptide C8 by using Ph.D.-C7 C phage display technology.C8 showed high binding affinity with h PD-1 and could effectively interfere the interaction of PD-1/PD-L1.Furthermore,C8 could stimulate CD8^(+)T cell activation in human peripheral blood mononuclear cells(PBMCs).We also observed that C8 could suppress tumor growth in CT26 and B16-OVA,as well as anti-PD-1 antibody resistant B16 mouse model.CD8^(+)T cells infiltration significantly increased in tumor microenvironment,and IFN-γsecretion by CD8^(+)T cells in draining lymph nodes also increased.Simultaneously,we exploited T cells depletion models and confirmed that C8 exerted anti-tumor effects via activating CD8^(+)T cells dependent manner.The interaction model of C8 with h PD-1 was simulated and confirmed by alanine scanning.In conclusion,C8 shows anti-tumor capability by blockade of PD-1/PD-L1 interaction,and C8 may provide an alternative candidate for cancer immunotherapy. | Wenjie Zhai Xiuman Zhou Mingxia Zhai Wanqiong Li Yunhui Ran Yixuan Sun Jiangfeng Du Wenshan Zhao Lingxiao Xing Yuanming Qi Yanfeng Gao | 2021 | Science China(Life Sciences)2021，64，4： | 5 |
| 15 | The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study显示文摘Background:An increasing number of cancer patients die of cardiovascular diseases.The cardiotoxicity of chemo-therapy is particularly important in triple-negative breast cancer(TNBC)with limited therapeutic options.Cardiac autophagy is an important mechanism of cardiotoxicity.This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC,screen the susceptible population,and determine the relationship between cardiotoxicity and autophagy-related polymorphisms.Methods:From a total of 2450 stage I-III TNBC patients,147 met the inclusion criteria and finally recruited.Electro-cardiography(ECG)was performed before most chemotherapy cycles,and echocardiography(UCG)was performed according to clinical needs.All ECG and UCG records were re-interpreted by cardiologists at the National Center for Cardiovascular Disease,Fuwai Hospital.According to the National Center for Biotechnology Information and the Catalog of Somatic Mutations in Cancer database,we selected 25 single nucleotide polymorphisms(SNPs)related to autophagy and genotyped the 147 TNBC patients.Paired-sample T tests,Chi squared tests,and logistic regression models were employed for the analysis.Results:Only 46(31.3%)patients had normal ECG records after every chemotherapy cycle.Among the 16 patients who underwent UCG,2(12.5%)had a reversible decrease of left ventricular ejection fraction.The use of anthracyclines and excessive alcohol consumption were risk factors of ECG abnormalities.With the continuation of chemotherapy,heart rate gradually increased.Anthracyclines were associated with QRS duration abnormalities(P=0.043).After genotyping for 25 autophagy-related SNPs,we found that the G allele of autophagy-related 13(ATG13)rs10838611 was significantly associated with ECG abnormalities(odds ratio=2.258,95%confidence interval=1.318-3.869;P=0.003).Conclusion:ECG abnormalities caused by chemotherapy are common in the real world.Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity,thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage. | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2018 | Cancer Communications2018，38，1： | 5 |
| 16 | Space-confined growth of monolayer ReSe2 under a graphene layer on Au foils显示文摘Vertical heterostructures based on two-dimensional(2D)materials have attracted widespread interest for their numerous applications in electronic and optoelectronic devices.Herein,we report the direct construct!on of an abnormal graphene/ReSe2 stack on Au foils by a two-step chemical vapor deposition(CVD)strategy.During the second growth stage,mono layer ReSe2 is found to prefere ntially evolve at the irUerface between the first-grown graphene layer and the Au substrate.The unusual stacking behavior is unraveled by in-situ'cutting open'the upper graphene from the defects to expose the lower ReSe2 using scanning tunneling microscopy(STM).From combination of these results with density functional theory calculations,the domain boundaries and edge sites of graphene are proposed to be adsorption sites for Re and Se precursors,further facilitating the growth of ReSe2 at the van der Waals gap of graphene/Au.This work hereby offers an intriguing strategy for obtaining vertical 2D heterostructures featured with an ultra-clean interface and a designed stacking geometry. | Chunyu Xie Shaolong Jiang Xiaolong Zou Yuanwei Sun Liyun Zhao Min Hong Shulin Chen Yahuan Huan Jianping Shi Xiebo Zhou Zhepeng Zhang Pengfei Yang Yuping Shi Porun Liu Qing Zhang Peng Gao Yanfeng Zhang | 2019 | Nano Research2019，12，1： | 4 |
| 17 | Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems显示文摘Polye-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone)(PCL-b-PEG-b-PCL,PCEC) triblock copolymers have been widely investigated in last several decades.Here,by altering the weight ratio of monomers in ring-opening polymerization,a series of PCEC triblock copolymers with varying hydrophobicity were synthesized,which were characterized by FTIR,1 H NMR,GPC and DSC.When PCEC copolymers with different weight ratios of PCL/PEG were dispersed in different aqueous solutions,they could self-assemble and form two distinctive nanoparticular structures:micelles or polymersomes.We then chose paclitaxel(PTX) as the model drug and encapsulate PTX into PCEC polymeric micelles and polymersomes.The physicochemical characterizations of the nanoparticles such as morphology,the size and distribution,zeta potential,drug loading content,and encapsulation efficiency were also performed.Our results showed that polymeric micelles or polymersomes from PCEC both displayed narrow size distributions and could achieve high drug loading efficiencies.In vitro cellular uptake results suggested that Nile Red loaded polymeric micelles or polymersomes displayed more internalization after 24 h incubation than those after 4 h incubation.These findings suggest that polymeric micelles and polymersomes based on PCL-b-PEG-b-PCL copolymers have great potential to effectively delivery hydrophobic drugs. | Chunyan Hu Zhuo Chen Shengjie Wu Yanfeng Han Hai Wang Hongfan Sun Deling Kong Xigang Leng Chun Wang Linhua Zhang Dunwan Zhu | 2017 | Chinese Chemical Letters2017，28，9： | 4 |
| 18 | Water quality criteria for 4-nonylphenol in protection of aquatic life显示文摘Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the reproductive system. Assessment factor (AF) and species sensitivity distribution (SSD) curve were employed to derive criteria maximum concentration (CMC) and criteria continuous concentration (CCC) of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols (CAS No: 104405, 25154523, 84852163) were 26.7, 13.6, 3.84 g L 1 and 8.86, 2.21, 0.97 g L 1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols (CAS No: 104405, 25154523) were 1.59 and 1.34 g L 1, respectively. The CCC values obtained by the AF for three different 4-nonylphenol (CAS No: 104405, 25154523, 84852163) were 0.165, 1.03, 0.74 g L 1 and 0.5, 0.5, 0.1 g L 1, respectively, based on death toxicity data and reproductive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors. | LEI BingLi LIU Qian SUN YanFeng WANG YiPei YU ZhiQiang ZENG XiangYing FU JiaMo SHENG GuoYing | 2012 | Science China Earth Sciences2012，55，6： | 4 |
| 19 | The formation of perovskite multiple quantum well structures for high performance light-emitting diodes显示文摘Recent works showed that high efficient perovskite light-emitting diodes can be achieved from solution-processed,self-organized multiple quantum wells(MQWs)with an energy cascade.We investigate how the mixing of QWs with different band gaps can affect the perovskite LED device performance.We find that the annealing process can significantly affect the constitution of the MQWs films,where the dominant phase can evolve from large band gap QWs to small band gap QWs.The optimal constitution for LED application lies in a transition point of small-n QWs dominant phase to large-n QWs dominant phase,when the MQW film presents highest photoluminescence while still remains uniform film morphology. | Yan Sun Li Zhang Nana Wang Shuting Zhang Yu Cao Yanfeng Miao Mengmeng Xu Hao Zhang Hai Li Chang Yi Jianpu Wang Wei Huang | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 20 | A modified HLA-A^(*)0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses显示文摘We previously identified human phosphatidylethanolamine-binding protein 4(hPEBP4)as an antiapoptotic protein with increased expression levels in breast,ovarian and prostate cancer cells,but low expression levels in normal tissues,which makes hPEBP4 an attractive target for immunotherapy.Here,we developed hPEBP4-derived immunogenic peptides for inducing antigen-specific cytotoxic T lymphocytes(CTLs)targeting breast cancer.A panel of hPEBP4-derived peptides predicted by peptide-MHC-binding algorithms was evaluated to characterize their HLAA2.1 affinity and immunogenicity.We identified a novel immunogenic peptide,P40–48(TLFCQGLEV),that was capable of eliciting specific CTL responses in HLA-A2.1/K^(b) transgenic mice,as well as in peripheral blood lymphocytes from breast cancer patients.Furthermore,amino-acid substitutions in the P40–48 sequence improved its immunogenicity against hPEBP4,a self-antigen,thus circumventing tolerance.We designed peptide analogs by preferred auxiliary HLA-A^(*)0201 anchor residue replacement,which induced CTLs that were crossreactive to the native peptide.Several analogs were able to stably bind to HLA-A^(*)0201 and elicit specific CTL responses better than the native sequence.Importantly,adoptive transfer of CTLs induced by vaccination with two analogs more effectively inhibited tumor growth than the native peptide.These data indicate that peptide analogs with high immunogenicity represent promising candidates for peptide-mediated therapeutic cancer vaccines. | Weihong Sun Junyi Shi Jian Wu Junchu Zhang Huabiao Chen Yuanyuan Li Shuxun Liu Yanfeng Wu Zhigang Tian Xuetao Cao Nan Li | 2018 | Cellular & Molecular Immunology2018，15，8： | 4 |
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