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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 3 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 4 | The Impact of Environmental Uncertainty on the Market Orientation - Performance Relationship : A Study of the Hospital Industry显示文摘 | Subhash C Loniall P S Raju | 2001 | Journal of Economic and Social Research2001，3，1： | 1 |
| 5 | Cortisol promotes and integrates the osmotic competence of the organs in North African catfish (Clarias gariepinus Burchell): Evidence from in vivo and in situ approaches显示文摘 | Babitha G S Subhash P M C | 2010 | General and Comparative Endocrinology2010，168，1： | 1 |
| 6 | Pyridazolate-bridged dicopper (Ⅱ) SOD mimics with enhanced antiproliferative activities against estrogen and androgen independent cancer cell lines 显示文摘 | Sabari D Subhash P Fakhara A | 2005 | Inorg Chim Acta2005，358，： | 1 |
| 7 | Tcrpcnoid diversity in the leaf essential oils of Himalayan Lauraceae species显示文摘 | Subhash C J Rajendra C P Dinesh S B ct al | 2009 | Chemistry Biodiveritys2009，6，9： | 1 |
| 8 | Tobacco Rattle Virus Vector: A Rapid and Transient Means of SilencingManduca sexta Genes by Plant Mediated RNA Interference显示文摘 | Pavan K Sagar Subhash P Ian T B | 2012 | PLoS ONE2012，7，31： | 1 |
| 9 | Visual and auditory evoked potentials in early onset Parkinson's diease and their relation ship to cerebrospinal fluid monoa mine metabolites显示文摘 | MuthaneUB Satishchandra P Subhash MN | 1993 | Mov Disord1993，8，2： | 1 |
| 10 | Synthesis andcharacterization of copper ( Ⅱ ) complexes of pyridine-2- carboxamidrazones as potent antimalarial agents 显示文摘 | Nikhil G Subhash P Dan R | 2001 | lnorg Chem Commun2001，，4： | 1 |
| 11 | Evaluation of cyclic hot corrosion behavior of detonation gun sprayed Cr3C2-25% NiCr coatings on nickel-and iron-based superalloys 显示文摘 | Subhash K Jayaganthan R Satya P | 2009 | Surface & Coatings Technology2009，203，8： | 1 |
| 12 | Transition metal complexes of semicarbazones and thiosem icarbazones 显示文摘 | Subhash P George B K | 1985 | Coordination Chemistry Reviews1985，63，： | 1 |
| 13 | catalytic antibody route to the naturally occurring epothilones:total synthesis of epothilones A-F显示文摘 | Subhash C S Sun J Miller G P | 2001 | J Chem Eur2001，7，8： | 1 |
| 14 | 显示文摘 | Pradeep P Phule Subhash H Risbud | 1990 | J Mater Sci1990，25，1： | 1 |
| 15 | Laser-induced damage to spray pyrolysis deposited transparent conducting films显示文摘 | Radhakrishnan P Sathianandan K Subhash N | 1986 | J Appl Phys1986，59，3： | 1 |
| 16 | A facile total synthesis of rutaecarpine 显示文摘 | Subhash P C R Sivappa | 2004 | Tetrahedron Lett2004，45，5： | 1 |
| 17 | Perspectives on medicinal properties of plumbagin and its analogs显示文摘 | SUBHASH P PRASAD D MUJAHID Y | 2010 | Med Res Rev2010，32，： | 1 |
| 18 | Dynamic analysis of staggered truss Framing System 显示文摘 | Raj P Gupta and Subhash C Goel | 1972 | Journal of Structure Division1972，98，7： | 1 |
| 19 | Heat transfer in a visco-elastic fluid past a stretching sheet with viscous dissipation and internal heat generation 显示文摘 | Veena P H Subhash Abel M Rajagopal K Pravin V K | 2006 | Zeitschrifl fi~r Angewandte Mathematik und Physik (ZAMP)2006，57，3： | 1 |
| 20 | Review-Low tern- perature Synthesis and Processing of Electronic Materials in theBaO TiO2 System显示文摘 | Pradeep P Phule Subhash H Risbud | 1990 | Journal of Materials Science1990，5，6： | 1 |
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