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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | Air contamination of basaltic magmas: Implications for high ^3He/^4 He mantle Ar isotopic composition 显示文摘 | Burnard P G Stuart F M Turner G Oskarsson N | 1994 | Jourrtal of Geophysical Research1994，9，17： | 1 |
| 5 | Boards, CEOs, and Surviving a Financial Crisis: Evidence from the Internet Shakeout 显示文摘 | DOWELL G W S SHACKELL M B STUART N V | 2011 | Strategic Management Journal2011，32，10： | 1 |
| 6 | Wormlike micellar and vesicular phases in aqueous solutions of single-tailed surfac- rants with aromatic counterions 显示文摘 | Buwalda T R Stuart M C A Engberts J B F N | 2000 | Langmuir2000，16，： | 1 |
| 7 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 8 | Simple methodsfor measurement of bovine mucosal antibody responses in vivo显示文摘 | TOM N M STUART W N MAIRI C M | 2007 | Veterinary Immunology and Immunopathology2007，118，： | 1 |
| 9 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 10 | Eutectic nucleation in A1-Si alloys 显示文摘 | Stuart D M Kazuhiro N Ame K D | 2004 | ActaMaterialia2004，52，： | 1 |
| 11 | Wormlike micellar and vesicular phases in aqueous solutions of single - tailed surfactants with aromatic counterions 显示文摘 | BUWALDA T R STUART M C A ENGBERTS J B F N | 2000 | Langmuir2000，16，： | 1 |
| 12 | CD95 Ligand ( FasL) induced apoptosis is necessary for corneal allograft survival显示文摘 | Stuart P M Griffith T S Usui N | 1997 | J Clin Invest1997，99，3： | 1 |
| 13 | Enhancment of ovulation rate in gilts by increasing diatary engry and administering insulin during follicular growth 显示文摘 | Cox N M Stuart T G Althen W A | 1987 | Anim Sci1987，64，： | 1 |
| 14 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 15 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 16 | Epithelioid sarcoma-like(pseudomyogenic)hemangioendothelioma, clinically mimicking dermatofibroma, diagnosed by skin biopsy in a 30-year-old man 显示文摘 | Stuart L N Gardner J M Lauer S R | 2013 | J Cutan Pathol2013，40，10： | 1 |
| 17 | Orf virus IL 10 accelerates wound healing while limiting inflammation and scarring显示文摘 | Wise L M Stuart G S Real N C | 2014 | Wound Repair Regen2014，22，3： | 1 |
| 18 | Emerging organic contaminants in groundwater: A review of sources, fate and occurrence 显示文摘 | Lapworth D J Baran N Stuart M E | 2012 | Environmental Pollution2012，163，： | 1 |
| 19 | A pilot study of the safety and effects of the matrix metallo-proteinase inhibitor marimastat in gastric cancer 显示文摘 | TIERNEY G M GRIFFIN N R STUART R C | 1999 | Eur J Cancer1999，35，4： | 1 |
| 20 | Pantoprazole reduces the size of postbanding ulcers after variceal band ligation : a randomized, controlled trial 显示文摘 | Shaheen N J Stuart E Schmitz S M | 2005 | Hepatology2005，41，3： | 1 |
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