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320篇 您的检索式:作者名="STUART A M"
    题名 作者 年代 出处 被引量
1Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski 2012Gut2012,,10:3
2Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz 2012Hepatobiliary & Pancreatic Diseases International2012,11,4:3
3Tensile Testing of EP-823 and HT-9 After Irradiation in STIP Ⅱ 显示文摘Maloy Stuart A Romero T James M R 2006Journal of Nuclear Materials2006,356,123:1
4Emerging ap- plications of stimuli-response polymer materials 显示文摘Stuart M A C Huck W T S Genzer J 2010Nat Mater2010,9,:1
5Self- consistent field theory of protein adsorption in a non- Gaussian polyelectrolyte brush显示文摘Biesheuvel P M Leermakers F A M Stuart M A C 2006Physical Review E2006,73,01:1
6Embrittlement of Irradiated Ferritic/Martensitic Steels in the Absence of Irra diation Hardening 显示文摘Maloy Stuart A Romero T James M R 2008Journal of Nuclear Materials2008,377,3:1
7Exponential mean- square stability of numerical solutions to stochastic differ- ential equations 显示文摘Higham D J Mao X R Stuart A M 2003LMS Journal of Computation and Mathematics2003,6,:1
8Structure and receptor binding显示文摘Jackson T Ning A M Stuart D I 2003Virus2003,91,:1
9Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children显示文摘Gómez F M Patel P A Stuart S 2014Pediatric Radiology2014,44,10:1
10MCMC methods for functions:modifying old algorithms to make them faster显示文摘COTTER S L ROBERTS G O STUART A M 2013Statistical Science2013,28,3:1
11Stimulation of lipolysis by Tumor Necrosis Factor-a in 3T3-L1 adipocytes is glucose dependent显示文摘Green A Rumberger J M Stuart C A 2004Diabetes2004,53,:1
12Structure and receptor binding 显示文摘Jackson T King A M Stuart D I 2003Virus Res2003,91,:1
13Structure and receptor binding 显示文摘Jackson T King A M Q Stuart D I 2003Virus Res2003,91,:1
14Nonionic bolaamphiphiles and Gemini surfactants based on carbohydrates显示文摘Pestman J M Terpstra K R Stuart M C A 1997Langmuir1997,13,25:1
15Emerging applications of stimuli-responsive polymer materials显示文摘Stuart M A C Huck W T S Genzer J 2010Nature Materials2010,9,:1
16T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation:a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)显示文摘Hazenberg M D Stuart J W Otto S A 2000{H}Blood2000,,01:1
17Fracture Resistance Characterization of Chemically Modified Crumb Rubber Asphalt Pavement 显示文摘MULL M A STUART K YEHIA A 2002Journal of Materials Science2002,37,3:1
18Wormlike micellar and vesicular phases in aqueous solutions of single-tailed surfac- rants with aromatic counterions 显示文摘Buwalda T R Stuart M C A Engberts J B F N 2000Langmuir2000,16,:1
19Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers 显示文摘Stuart C A Howell M E Baker J D 2010Med Sci Sports Exerc2010,42,1:1
20Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T 1997Ecology1997,78,2:1
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