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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Selective detection of aroma compontents by acoustic wave sensors coated with conducting polymers films显示文摘 | Deng Z P Stone D C Thompson M | | Analyst0，121，： | 2 |
| 5 | Catalysis at the metal-support interface: exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P | 2003 | J Catal2003，217，2： | 2 |
| 6 | A muhl-model update on the detection and attribution of global surface warming显示文摘 | Stone D A Allen M R Stott P A | 2007 | Journal of Climate2007，20，： | 1 |
| 7 | Interaction of themaize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases,implications for transmembrane signalling in plants显示文摘 | Braun D M Stone J M Walker J C | 1997 | Plant J1997，12，： | 1 |
| 8 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 9 | 查看详情显示文摘 | Humphry K J Kulkarni P M Weitz D A Morris J F Stone H A | | 0，，： | 1 |
| 10 | A dynamic range compression andthree-dimensional peptide fractionation analysisplatform expands proteome coverage and thediagnostic potential of whole saliva 显示文摘 | BANDHAKAVI S STONE M D ONSONGOG | 2009 | Journalof Proteome Research2009，8，55： | 1 |
| 11 | Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A | 2003 | J Catal2003，217，2： | 1 |
| 12 | Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae 显示文摘 | WALTZEK T B KELLEY G O STONE D M | 2005 | J Gen Virol2005，86，： | 1 |
| 13 | A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the trigger-PCl (testing platelet reactivity in patients undergoing elective stent placement on clopidogrel to guide alternative therapy with prasugrel) study显示文摘 | TRENK D STONE G W GAWAZ M | 2012 | J Am Call Cardiol2012，59，24： | 1 |
| 14 | Anisotropic site-site potentials molecular dynamics显示文摘 | STONE A J TILDESLEY D J | 1992 | Molecular Simulation1992，8，： | 1 |
| 15 | Human contribution to the European heatwave of 2003 显示文摘 | Stott P A Stone D A Allen M R | 2004 | Nature2004，432，： | 1 |
| 16 | Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion the spot sign score显示文摘 | Almandoz J E D Yoo A J Stone M J | 2009 | Stroke2009，40，9： | 1 |
| 17 | Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1,a putative component of the exocyst complex显示文摘 | Samuel M A Chong Y T Haasen K E Aldea-Brydges M G Stone S L Goring D R | | 0，，09： | 1 |
| 18 | How Should Monetary Policy Respond to Asset -Price Bubbles? 显示文摘 | Gruen D M Plumb and A Stone | 2005 | International Journal of Central Banking2005，1，3： | 1 |
| 19 | Microsporidia: diverse, dynamic, and emergent pathogens in aquatic systems 显示文摘 | STENTIFORD G D FEIST S W STONE D M | 2013 | Trends in Parasitology2013，29，11： | 1 |
| 20 | A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents , results of the TRIGGER-PCI (Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Tberapy With Prasugrel ) study显示文摘 | Trenk D Stone GW Gawaz M | 2012 | J Am Coli Cardiol2012，59，24： | 1 |
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