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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | An update for the calculation of reference evapotranspiration显示文摘 | ALLEN R G SMITH M | 1994 | ICID Bulletin1994，43，2： | 2 |
| 3 | Porter's generic strategies:An exploratory study of their use in JAPAN显示文摘 | Allen R S Helms M M Takeda M B | 2007 | Journal of Business Strategies2007，24，1： | 1 |
| 4 | Risky business:The role of risk in voluntary turnover decisions显示文摘 | David G Allen Robert W R Karen R MJarnes M V | 2007 | Human Resource Management Review2007，17，： | 1 |
| 5 | Nontricyclic Antidepressant Agents Derived from cis- and trans-1-Amino-4-arytetralins 显示文摘 | Welch W M Kraska Allen R Sarges R | 1984 | J Med Chem1984，27，11： | 1 |
| 6 | A muhl-model update on the detection and attribution of global surface warming显示文摘 | Stone D A Allen M R Stott P A | 2007 | Journal of Climate2007，20，： | 1 |
| 7 | Measurement of flour color in color space parameters 显示文摘 | Oliver J R Blakeney A B Allen H M | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 8 | Drug delivery systems:entering the mainstream显示文摘 | Allen T M Cullis P R | 2004 | Science2004，303，： | 1 |
| 9 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 10 | Evaluation of effectiveness and satisfaction outcomes of a mental health screening and referral clinical pathway for community nursing care显示文摘 | Allen J Annells M Nunn R | 2011 | Journal of psychiatric and mental health nursing2011，18，5： | 1 |
| 11 | Biodegradabe polymer microneedles: Fabrication, mechanics and transdermal drug delivery 显示文摘 | Park J H Allen M G Prausnitz M R | 2005 | Journal of Controlled Release2005，10，1： | 1 |
| 12 | Segmenting Local Residents by their Attiudes,Interests and Opinions toward Tourism显示文摘 | Davis D J Allen R M Cosenza | 1988 | Journal of Travel Research1988，27，2： | 1 |
| 13 | Assessment of the endoscopic semitendinosus/gracilis autograft procedure with interference screw fixation for reconstruction of the anterior cruciate ligament显示文摘 | Allen A D Sitler M R Marchetto P | 2001 | Orthopedics2001，24，4： | 1 |
| 14 | Operational estimates of reference evapotranspiration显示文摘 | ALLEN R G JENSEN M E WRIGHT J L | 1989 | Agron J1989，81，： | 1 |
| 15 | Shear mode crack growth and rolling contact fatigue显示文摘 | BOLD P E BROWN M W ALLEN R J | 1991 | Wear1991，144，： | 1 |
| 16 | Drug delivery systems: Eentering the mainstream 显示文摘 | Allen T M Cullis P R | 2004 | Science2004，303，5665： | 1 |
| 17 | TheRole of Perceived Organizational Support and Sup-portive Human Resource Practices in the TurnoverProcess 显示文摘 | ALLEN D G SHORE L M GRIFFETH R W | 2003 | Journal of Management2003，29，2： | 1 |
| 18 | Operational estimates of reference evapotranspiration显示文摘 | Allen R G Jensen M E Wright J L | 1989 | Agron J1989，81，： | 1 |
| 19 | Periprosthetic osteolysis: an immunologist?s update显示文摘 | R John Looney Edward M Schwarz Allen Boyd Regis J O?Keefe | 2006 | Current Opinion in Rheumatology2006，，1： | 1 |
| 20 | Operational estimates of reference evapotranspiration显示文摘 | Allen R G Jensen M E Burman R D | 1989 | Agron J1989，81，： | 1 |
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