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| 1 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 2 | E2 enzymes: more than just middle men显示文摘 | Mikaela D Stewart Tobias Rltterhoff Rachel E Klevit Peter S Brzovic | 2016 | Cell Research2016，26，4： | 17 |
| 3 | Applicability of five models to simulate water infiltration into soil with added biochar显示文摘As a soil amendment, biochar can reduce soil bulk density, increase soil porosity, and alter soil aggregates and thus affect the infiltration. Researchers have proposed and revised several theoretical models to describe the process of soil infiltration. Although these models have been successfully used to evaluate the soil infiltration in different scenarios in agricultural fields, little effort has been devoted to assess their performances in arid and semi-arid soils after the addition of biochar. A laboratory experiment was performed to study the infiltration characteristics of two typical Loess Plateau soils at three particle sizes(2–1, 1–0.25, and <0.25 mm) and five biochar application amounts(0, 10, 50, 100, and 150 g/kg). The performance of five models(i.e., the Philip model, Kostiakov model, Mezencev model, USDA-NRCS model, and Horton model) in simulating the infiltration process was then evaluated based on the adjusted coefficient of determination and a reduced Chi-Square test. Results indicated that the Horton model best simulated the water-infiltration process in an aeolian sandy soil with added biochar. However, the Mezencev model best simulated the infiltration process in a loamy clay soil(Eum-Orthic Anthrosol). The three-parameter model, i.e., Mezencev and Horton models can better describe the relationship between cumulative infiltration and infiltration time. In conclusion, biochar reduced the soil infiltration capacity of the aeolian sandy soil and increased that of the Eum-Orthic Anthrosol. | WANG Tongtong Catherine E STEWART MA Jiangbo ZHENG Jiyong ZHANG Xingchang | 2017 | Journal of Arid Land2017，9，5： | 9 |
| 4 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 5 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 6 | Characterization and target identification of a DNA aptamer that labels pluripotent stem cells显示文摘 | Zhonggang Hou Susanne Meyer Nicholas E Propson jeff Nie Peng Jiang Ron Stewart James A Thomson | 2015 | Cell Research2015，25，3： | 5 |
| 7 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 8 | 特发性肺间质纤维化患者疱疹病毒感染与血管重塑、肺高血压相关显示文摘肺高血压是特发性肺问质纤维化(idiopathic pulmonary fibrosis,IPF)的主要并发症,对患者预后有不良影响。目前认为疱疹病毒在IPF的发生发展过程中起致病作用。病毒对IPF相关的肺高血压的影响尚不清楚。该研究重点探讨病毒对IPF患者肺高血压相关方面的影响,同时还对γ疱疹病毒[鼠疱疹病毒68(maus herpesvirus 68,MHV-68)]诱发的肺间质纤维化实验室小鼠模型进行评估。 | Calabrese F Kipar A Lunardi F Balestro E Perissinotto E Rossi E Nannini N Marulli G Stewart JP Rea F 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 9 | Scientific charge-coupled devices显示文摘 | JANESICK J R TOM E STEWART C | 1987 | Optical Engineering1987，26，8： | 2 |
| 10 | CT imaging af angiogenesis显示文摘 | Lee TH Purdie TG Stewart E | 2003 | Quarterly J Nuclear Medicine2003，47，： | 1 |
| 11 | Bacterial biofilms: a common cause of persistent infections显示文摘 | COSTERTON J W STEWART P S GREENBERG E P | 1999 | Science1999，284，： | 1 |
| 12 | Category Interference in Translation and Picture Naming: Evidence for Asymmetric Connections Between Bilingual Memory Representations显示文摘 | Kroll J F Stewart E | 1994 | Journal of Memory and Language1994，33，： | 1 |
| 13 | Microdosimetric properties of ionizing electrons in water显示文摘 | STEWART R D WILSON W E MCDONALD J C | 2002 | Phys Med Biol2002，47，1： | 1 |
| 14 | A systematic review of resilience in the physieallyill显示文摘 | Stewart D E Yuen T | 2011 | Psychosomatics2011，52，3： | 1 |
| 15 | Simple non- invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease 显示文摘 | McPherson S Stewart SF Henderson E | 2010 | Gut2010，59，12： | 1 |
| 16 | Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice显示文摘 | Stewart M J Plautz G E Del Buono L | 1992 | Hum Gene Ther1992，3，3： | 1 |
| 17 | Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays 显示文摘 | DONG Yah Ganther H E Stewart C | 2002 | Cancer Res2002，62，3： | 1 |
| 18 | Bacterial biofilm: A common cause of persistent infection 显示文摘 | Stewart P S Greenberg E P | 1999 | Science1999，284，： | 1 |
| 19 | Bacterial bio- films: a common cause of persistent infections显示文摘 | COSTERTON J W STEWART P S GREENBERG E P | 1999 | Science1999，284，5418： | 1 |
| 20 | A gene map of the human genome显示文摘 | Schuler G D Boguski M S Stewart E A | 1996 | Science1996，274，： | 1 |
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