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| 1 | Hepatitis B virus and micro RNAs:Complex interactions affecting hepatitis B virus replication and hepatitis B virusassociated diseases显示文摘Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause of cancer-related death in the world. Unfortunately, the molecular mechanisms that contribute to the development of HBV-associated HCC remain incompletely understood. Recently, micro RNAs(mi RNAs), a family of small non-coding RNAs that play a role primarily in post-transcriptional gene regulation, have been recognized as important regulators of cellular homeostasis, and altered regulation of mi RNA expression has been suggested to play a significant role in virus-associated diseases and the development of many cancers. With this in mind, many groups have begun to investigate the relationship between mi RNAs and HBV replication and HBV-associated disease. Multiple findings suggest that some mi RNAs, such as mi R-122, and mi R-125 and mi R-199 family members, are playing a role in HBV replication and HBV-associated disease, including the development of HBV-associated HCC. In this review, we discuss the current state of our understanding of the relationship between HBV and mi RNAs, including how HBV affects cellular mi RNAs, how these mi RNAs impact HBV replication, and the relationship between HBV-mediated mi RNA regulation and HCC development. We also address the impact of challenges in studying HBV, such as the lack of an effective model system for infectivity and a reliance on transformed cell lines, on our understanding of the relationship between HBV and mi RNAs, and proposepotential applications of mi RNA-related techniques that could enhance our understanding of the role mi RNAs play in HBV replication and HBV-associated disease, ultimately leading to new therapeutic options and improved patient outcomes. | Jason Lamontagne Laura F Steel Michael J Bouchard | 2015 | World Journal of Gastroenterology2015，21，24： | 17 |
| 2 | Variation and mechanisms of clastic reservoir quality in the Paleogene Shahejie Formation of the Dongying Sag, Bohai Bay Basin, China显示文摘Reservoir quality varies greatly in the Shahejie Formation in the Dongying Sag. It is essential to analyze the variation and mechanisms of reservoir quality for determining the controlling factors based on cores, porosity measurements and fluid inclusion techniques and so on. The sandstones in the fluvial,(fan) delta-front have the best reservoir quality due to the depositional conditions mechanically controlling the petrology configuration and the primary porosity, and chemically influencing the diagenesis and development of secondary pores. The activity of the boundary faults and the sedimentary facies dominate the variation of reservoir quality in different areas and intervals. The reservoir quality varies with the position of sandstone beds in different vertical models of sandstone and mudstone. This mainly arose from the strong cementation or strong dissolution in the sandstone caused by the diagenesis evolution of adjacent mudstone. With higher oil saturation reservoir quality is better because the hydrocarbon charge favors dissolution and restricts cementation. Diagenesis, depositional conditions and tectonic setting are the key controls of reservoir quality in the Shahejie Formation of the Dongying Sag. | Zhang Qin Zhu Xiaomin Ronald J Steel Zhong Dakang | 2014 | Petroleum Science2014，11，2： | 16 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 4 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 5 | 美国(2005-2014年)与超重和肥胖有关的癌症发病率的趋势带来的思考显示文摘背景超重和肥胖与至少13种不同类型癌症的风险增加有关。方法 2014年美国癌症统计数据用于评估发病率,2005至2014年的数据用于评估与超重和肥胖相关的癌症趋势[食管腺癌;乳癌(绝经后妇女),结肠、直肠、子宫内膜、胆囊、胃贲门、肾脏、肝脏、卵巢、胰腺、甲状腺癌;脑膜瘤;多发性骨髓瘤]。结果2014年,美国大约有631 000人被诊断为超重和肥胖相关的癌症,占所有被诊断癌症者的40%。超重和肥胖引起的癌症发病率老年人(年龄≥50岁)普遍高于年轻人;女性高于男性;非西班牙裔黑人和非西班牙裔白人成年人与其他群体相比更高。在2005-2014年期间,超重和肥胖相关癌症的发病率因年龄、癌症地点和州的不同而不同。除结直肠癌外,其他超重和肥胖相关癌症的发病率在年龄20~74岁之间的人群显著增加;在年龄≥75岁人群中减少;在32个州中增加;在16个州和哥伦比亚特区稳定。结论美国超重和肥胖相关的癌症负担很高。在一些年龄组和州中,除结直肠癌外,超重和肥胖相关癌症的发生率增加。对公共卫生实践的影响:超重和肥胖相关癌症的负担可能通过努力预防和控制超重和肥胖而减少。综合癌症控制策略,包括使用循证干预措施来促进健康体质量,可以帮助降低美国癌症的发病率。 | 徐斌峰 陈刚 steele c b thomas c c henley s j | 2018 | 福建医药杂志2018，40，1： | 4 |
| 6 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 7 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 8 | 肥胖与肺功能改变具有独立于体力活动和身体素质的相关性显示文摘慢性呼吸道疾病会使人群死亡率增高,轻度肺功能受损者临床症状可能不明显,但是也会增加人群呼吸道和其他原因的死亡率,而且增加心脑血管疾病、胰岛素抵抗和糖尿病的发生风险。重度肥胖患者常伴有哮喘和阻塞性睡眠呼吸暂停综合征等呼吸道并发症, | Steele RM Finucane FM Griffin S J 王海俊 | 2012 | 中华预防医学杂志2012，46，9： | 2 |
| 9 | Gearlike rolling motion mediated by commensurate contact: carbon nanotubes on HOPG 显示文摘 | Falvo M R Steele J Taylor Ⅱ R M | 2000 | Phys Rev B2000，62，10： | 1 |
| 10 | Wheat classification using image analysis and crush-force parameters 显示文摘 | ZayasI Martin C R Steele J L | 1996 | Trans of the ASAE1996，39，： | 1 |
| 11 | High transmission Enhanced Faraday Rotation in One-dimensional Photonic Crystals with Defects显示文摘 | STEEL M J LEVY M OSGOOD R M | 2000 | IEEE Photon Technol Lett2000，12，： | 1 |
| 12 | Quantitating physical activity in coped using a triaxial accelerometer显示文摘 | Steele B G Holt I J Belza B | 2000 | Chest2000，117，5： | 1 |
| 13 | Examining the consequences of exposure to racism for the executive functioning of Black students 显示文摘 | BAIRN A STEELE R J | 2010 | J Experimental Soc Psychol2010，46，： | 1 |
| 14 | Mechanism of gold and silver species on activated carbon显示文摘 | Jia Y F Steele J Hayward P | 1998 | Carbon1998，36，9： | 1 |
| 15 | Wheat classification using image analysis and crush-force parameters显示文摘 | Zayas I Y Steele J L Katcevich A | 1996 | Transaotiona of the ASAE1996，39，6： | 1 |
| 16 | Gender and age affect balance performance in primary school-aged children显示文摘 | Mickle KJ Munro B J Steele JR | | 0，，： | 1 |
| 17 | Peroxi- some proliferator-activated receptor gamma (PPAR gam- ma) and its ligands: a review 显示文摘 | HOUSEKNECHT K L COLE B M STEELE P J | 2002 | Domest Anim Endocri- nol2002，22，1： | 1 |
| 18 | Current clinical immunother- apy targets in advanced nonsmall cell lung cancer(NSCLC)显示文摘 | McCarthy F Roshani R Steele J | 2013 | J Leukoc Biol2013，94，6： | 1 |
| 19 | A randomized trial of\snonoperative treatment for perforated peptic ulcer显示文摘 | Croft T J Park K G Steele R J | 1989 | N Engl J Med1989，320，15： | 1 |
| 20 | Effect of the plane of surgery a-chieved on local recurrence in patients with operable rectal cancer:a prospective study using data from the MRC CR07 and NCIC-CTGC016 randomised clinical trial 显示文摘 | Quirke P Steele R Monson J | 2009 | Lancet2009，373，9666： | 1 |
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