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| 1 | The precipitation strengthening behavior of Cu-rich phase in Nb contained advanced Fe-Cr-Ni type austenitic heat resistant steel for USC power plant application | Cheng-yu Chi a, Hong-yao Yu b, Jian-xin Dong b, Wen-qing Liu c, Shi-chang Cheng d, Zheng-dong Liu d, Xi-shan Xie b a School of Metallurgical and Ecological Engineering, University of Science & Technology Beijing, Beijing 100083, China b School of Materials Science and Engineering, University of Science & Technology Beijing, Beijing 100083, China c Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China d Central Iron and Steel Research Institute, Beijing 100081, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 20 |
| 2 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 3 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 4 | 美国(2005-2014年)与超重和肥胖有关的癌症发病率的趋势带来的思考显示文摘背景超重和肥胖与至少13种不同类型癌症的风险增加有关。方法 2014年美国癌症统计数据用于评估发病率,2005至2014年的数据用于评估与超重和肥胖相关的癌症趋势[食管腺癌;乳癌(绝经后妇女),结肠、直肠、子宫内膜、胆囊、胃贲门、肾脏、肝脏、卵巢、胰腺、甲状腺癌;脑膜瘤;多发性骨髓瘤]。结果2014年,美国大约有631 000人被诊断为超重和肥胖相关的癌症,占所有被诊断癌症者的40%。超重和肥胖引起的癌症发病率老年人(年龄≥50岁)普遍高于年轻人;女性高于男性;非西班牙裔黑人和非西班牙裔白人成年人与其他群体相比更高。在2005-2014年期间,超重和肥胖相关癌症的发病率因年龄、癌症地点和州的不同而不同。除结直肠癌外,其他超重和肥胖相关癌症的发病率在年龄20~74岁之间的人群显著增加;在年龄≥75岁人群中减少;在32个州中增加;在16个州和哥伦比亚特区稳定。结论美国超重和肥胖相关的癌症负担很高。在一些年龄组和州中,除结直肠癌外,超重和肥胖相关癌症的发生率增加。对公共卫生实践的影响:超重和肥胖相关癌症的负担可能通过努力预防和控制超重和肥胖而减少。综合癌症控制策略,包括使用循证干预措施来促进健康体质量,可以帮助降低美国癌症的发病率。 | 徐斌峰 陈刚 steele c b thomas c c henley s j | 2018 | 福建医药杂志2018，40，1： | 4 |
| 5 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 6 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 7 | Appraisal of Ce1-yGdyO1-y/2 electrolyte for IT-SOFC operation at 500 ℃ 显示文摘 | Steele B C H | 2000 | Solid State Ionics2000，129，： | 2 |
| 8 | Wheat classification using image analysis and crush-force parameters 显示文摘 | ZayasI Martin C R Steele J L | 1996 | Trans of the ASAE1996，39，： | 1 |
| 9 | Simple isolation of functional RNA from woody stems of gymnosperms显示文摘 | Lewinsohn E Steele C L Croteau R | 1994 | Plant Mol Biol Reptr1994，12，： | 1 |
| 10 | Intranasal insulin trial(INIT) in preclinical type 1 diabetes显示文摘 | Harrison LC Honeyman MC Steele C | 1999 | Diabetes1999，48，1： | 1 |
| 11 | A three-dimensional nonlinear active co- chlear model analyzed by the WKB-numerie method 显示文摘 | Lim K M Steele C R | 2002 | Hear Res2002，170，12： | 1 |
| 12 | Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor 显示文摘 | Wykes T Steel C Everitt B | 2008 | Schizophr Bull2008，34，3： | 1 |
| 13 | Recent developments and current controversies in depression显示文摘 | Ebmeier KP Donaghey C Steele JD | 2006 | Lancet2006，367，9505： | 1 |
| 14 | Candidate DNA meth-ylation drivers of acquired cisplatin resistance in ovariancancer identified by methyiome and expression profiling显示文摘 | Zeller C Dai W Steele NL | 2012 | Oncogene2012，31，： | 1 |
| 15 | Correlates and outcomes of fatigue among incident dialysis patients显示文摘 | jhamh M Argyropoulos C Steel JL et at | 2009 | Clin J Am Soc Nephrol2009，，： | 1 |
| 16 | Towards the remote sensing of matorral vegetation physiology:relationships between spectral reflectance,pigment,and biophysical characteristics of semiarid bushland canopies显示文摘 | Blackburn G A Steele C M | | 0，，3： | 1 |
| 17 | Effect of soft and softer handoffs on CDMA system capacity显示文摘 | STEELE R | 1998 | IEEE Trans on Veh Technol1998，47，3： | 1 |
| 18 | Cytokine and chemokine production by human oral and vaginal epithelial cells in response to candida albicans显示文摘 | Steele C Fidel P L Jr | 2002 | Infect Immun2002，70，2： | 1 |
| 19 | Facilitators and outcomes of student engagement in a college setting 显示文摘 | STEELE J P FULLAGAR C J | 2009 | The Journal of Psychology2009，143，1： | 1 |
| 20 | Ligand exchange of some heterocyclic analogues of fluorine and anthracene with ferrocene显示文摘 | Steele K J Sutherland RG | 1980 | J Organomet Chem1980，186，： | 1 |
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