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| 1 | The Global Boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the uppermost of the Ordovician System)显示文摘 | Xu Chen Jiayu Rong Junxuan Fan Renbin Zhan Charles E. Mitchell David A. T. Harper Michael J. Melchin Ping'an Peng Stan C. Finney Xiaofeng Wang | 2006 | Episodes2006，29，3： | 61 |
| 2 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 3 | 预防性中央区淋巴结清扫治疗甲状腺乳头状癌的利与弊显示文摘对甲状腺乳头状癌(PTC)的患者是否行预防性的中央区淋巴结清扫(pCND)是存在争议的。相比于其他恶性肿瘤而言,PTC患者有较好的整体生存率,但由于淋巴结的转移而导致局部复发也是治疗的一个难点。与颈侧区淋巴结转移不同,中央区淋巴结转移在术前评估中不易被发现,并且第1次术后如中央区的病灶复发或残留可能需再次手术治疗,但是出现手术并发症的风险将增加。由于中央区淋巴结在位置上属于甲状腺切除术的区域内,所以行pCND可以减少复发的风险及再次手术的需要,但也需要衡量患者的风险及获益。笔者将通过长期的治疗效果来讨论pCND的优势及劣势,同时也将对pCND的合理性,单或双侧pCND的指征及常规行pCND和复发再手术的比较进行讨论。分子标志物在高危患者中的应用及患者术后生存质量的研究也有所提及。 | Anthony R.Glover Justin S.Gundara Olov Norlén James C.Lee Stan B.Sidhu 冯铁成 李新营 | 2014 | 中国普通外科杂志2014，23，5： | 10 |
| 4 | 炎症、动脉粥样硬化和心脑血管疾病显示文摘心脑血管疾病的病理基础是动脉粥样硬化,动脉粥样硬化被证实是细胞和分子的炎症反应。临床研究论证了炎症标记C 反应蛋白的增高预测心脑血管病发生的危险。C 反应蛋白已被美国心脏协会和疾病控制中心推荐为目前可信性最高的预测冠心病危险的临床检测指标,使极早期预测心脑血管疾病成为可能。至今发现的抗动脉炎症药物包括:阿司匹林、克皮格尔、他汀类降脂药和血管紧张素转换酶抑制剂。 | 赵莲 薛爽 陈芳 Stan Heptinstall | 2005 | 心血管病学进展2005，26，2： | 10 |
| 5 | 根据非线性贝叶斯理论的界面波频散曲线反演显示文摘通过时频分析法从海底环境噪声数据中提取界面波频散曲线,进而采用非线性贝叶斯反演方法估算海底沉积物厚度、剪切波速度、压缩波速度和密度等参数及其不确定性。参数的最大后验概率(MAP)估计值和边缘概率分布分别通过自适应单纯形模拟退火法和Metropolis-Hastings采样法在各参数先验区间内搜索获得,采用贝叶斯信息准则(BIC)从不同参数化模型中选择最优模型。界面波频散曲线反演结果表明:满足实测数据的最优海底模型结构为3层均匀分布剪切波速度剖面结构,海底深度的反演精度在800m以内,比起压缩波速度和密度,剪切波速度的不确定性更小,对界面波频散曲线更敏感。 | 李翠琳 Stan E Dosso Hefeng Dong | 2012 | 声学学报2012，37，3： | 10 |
| 6 | Machine-learned interatomic potentials by active learning:amorphous and liquid hafnium dioxide显示文摘We propose an active learning scheme for automatically sampling a minimum number of uncorrelated configurations for fitting the Gaussian Approximation Potential(GAP).Our active learning scheme consists of an unsupervised machine learning(ML)scheme coupled with a Bayesian optimization technique that evaluates the GAP model.We apply this scheme to a Hafnium dioxide(HfO2)dataset generated from a“melt-quench”ab initio molecular dynamics(AIMD)protocol.Our results show that the active learning scheme,with no prior knowledge of the dataset,is able to extract a configuration that reaches the required energy fit tolerance.Further,molecular dynamics(MD)simulations performed using this active learned GAP model on 6144 atom systems of amorphous and liquid state elucidate the structural properties of HfO2 with near ab initio precision and quench rates(i.e.,1.0 K/ps)not accessible via AIMD.The melt and amorphous X-ray structural factors generated from our simulation are in good agreement with experiment.In addition,the calculated diffusion constants are in good agreement with previous ab initio studies. | Ganesh Sivaraman Anand Narayanan Krishnamoorthy Matthias Baur Christian Holm Marius Stan Gábor Csányi Chris Benmore Álvaro Vázquez-Mayagoitia | 2020 | npj Computational Materials2020，，1： | 10 |
| 7 | Performance of heavy ductile iron castings for windmills显示文摘The main objective of the present paper is to review the specific characteristics and performance obtaining conditions of heavy ductile iron(DI) castings,typically applied in windmills industry,such as hubs and rotor housings.The requirements for high impact properties in DI at low temperatures are part of the ENGJS-400-18U-LT(SRN 1563) commonly referred to as GGG 40.3(DIN 1693).Pearlitic in-uence factor(Px) and antinodularising action factor(K1) were found to have an important in-uence on the structure and mechanical properties,as did Mn and P content,rare earth(RE) addition and inoculation power.The presence of high purity pig iron in the charge is extremely beneficial,not only to control the complex factors Px and K1,but also to improve the 'metallurgical quality' of the iron melt.A correlation of C and Si limits with section modulus is very important to limit graphite nodule flotation.Chunky and surface-degenerated graphite are the most controlled graphite morphologies in windmills castings.The paper concluded on the optimum iron chemistry and melting procedure,Mg-alloys and inoculants peculiar systems,as well as on the practical solutions to limit graphite degeneration and to ensure castings of the highest integrity,typically for this field. | Iulian Riposan Mihai Chisamera Stelian Stan | 2010 | China Foundry2010，7，2： | 9 |
| 8 | 四价人乳头瘤病毒疫苗的效力和效果:10年真实世界研究的系统综述显示文摘预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索PubMed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病变的效力或效果的观察性研究的报道。十年来,真实世界环境中HPV疫苗效果越来越明显,尤其在疫苗接种率较高国家中那些在HPV暴露发生之前接种的女孩。据报道,疫苗可使HPV6、11、16、18感染最多减少约90%,生殖器疣减少约90%,低度宫颈细胞学异常减少约45%,经组织学证实的高度宫颈异常减少约85%。但HPV疫苗接种计划的公共卫生潜力尚未完全实现,HPV相关疾病仍具有较高的发病率和死亡率,因此仍需要提高HPV疫苗接种计划的人群覆盖率。 | Suzanne M.Garland Susanne K.Kjaer Nubia Muoz Stan L.Block Darron R.Brown Mark J.DiNubile Brianna R.Lindsay Barbara J.Kuter Gonzalo Perez Geraldine Dominiak-Felden Alfred J.Saah Rosybel Drury Rituparna Das Christine Velicer 王华庆 | 2018 | 中国病毒病杂志2018，8，4： | 9 |
| 9 | New developments in high quality grey cast irons显示文摘The paper reviews original data obtained by the present authors,revealed in recent separate publications,describing specific procedures for high quality grey irons,and reflecting the forecast needs of the worldwide iron foundry industry.High power,medium frequency coreless induction furnaces are commonly used in electric melting grey iron foundries.This has resulted in low sulphur(<0.05wt.%)and aluminium(<0.005wt.%)contents in the iron,with a potential for higher superheating(>1,500°C),contributing to unfavourable conditions for graphite nucleation.Thin wall castings are increasingly produced by these electric melt shops with a risk of greater eutectic undercooling during solidification.The paper focused on two groups of grey cast irons and their specific problems:carbides and graphite morphology control in lower carbon equivalent high strength irons(CE=3.4%-3.8%),and austenite dendrite promotion in eutectic and slightly hypereutectic irons(CE=4.1%-4.5%),in order to increase their strength characteristics.There are 3 stages and 3 steps involving graphite formation,iron chemistry and iron processing that appear to be important.The concept in the present paper sustains a threestage model for nucleating flake graphite[(Mn,X)S type nuclei].There are three important groups of elements(deoxidizer,Mn/S,and inoculant)and three technological stages in electric melting of iron(superheat,pre-conditioning of base iron,final inoculation).Attention is drawn to a control factor(%Mn)x(%S)ensuring it equals to 0.03–0.06,accompanied by 0.005wt.%–0.010wt.%Al and/or Zr content in inoculated irons.It was found that iron powder addition promotes austenite dendrite formation in eutectic and slightly eutectic,acting as reinforcement for the eutectic cells.But,there is an accompanying possible negative influence on the characteristics of the(Mn,X)S type graphite nuclei(change the morphology of nuclei from polygonal compact to irregular polygonal,and therefore promote chill tendency in treated irons).A double addition(iron powder+inoculant)appears to be an effective treatment to benefit both austenite and graphite nucleation,with positive effects on the final structure and chill tendency. | Iulian Riposan Mihai Chisamera Stelian Stan | 2014 | China Foundry2014，11，4： | 8 |
| 10 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 11 | 硫代硫酸银和氨基乙氧乙烯甘氨酸对延长矮牵牛花期的效应显示文摘硫代硫酸银和氨基乙氧乙烯甘氨酸对延长矮牵牛花期的效应徐明全StanleyJ.Kays(江苏省农科院园艺所南京210014)(DepartmentofHorticultureUniversityofGeorgia)矮牵牛是一种广泛用于盆栽和花坛的花卉,... | 徐明全 Stan JK | 1994 | 江苏农业科学1994，22，3： | 7 |
| 12 | LIMS实施经验之谈显示文摘实验室必须花费必要的时间和资源去规划、选择并实施一个新的LIMS系统。 | George Avery Charles McGee Stan Falk 闫蕊 梁斌 | 2004 | 现代科学仪器2004，21，5： | 7 |
| 13 | A review:applications of the phase field method in predicting microstructure and property evolution of irradiated nuclear materials显示文摘Complex microstructure changes occur in nuclear fuel and structural materials due to the extreme environments of intense irradiation and high temperature.This paper evaluates the role of the phase field method in predicting the microstructure evolution of irradiated nuclear materials and the impact on their mechanical,thermal,and magnetic properties.The paper starts with an overview of the important physical mechanisms of defect evolution and the significant gaps in simulating microstructure evolution in irradiated nuclear materials.Then,the phase field method is introduced as a powerful and predictive tool and its applications to microstructure and property evolution in irradiated nuclear materials are reviewed.The review shows that(1)Phase field models can correctly describe important phenomena such as spatial-dependent generation,migration,and recombination of defects,radiation-induced dissolution,the Soret effect,strong interfacial energy anisotropy,and elastic interaction;(2)The phase field method can qualitatively and quantitatively simulate two-dimensional and three-dimensional microstructure evolution,including radiation-induced segregation,second phase nucleation,void migration,void and gas bubble superlattice formation,interstitial loop evolution,hydrate formation,and grain growth,and(3)The Phase field method correctly predicts the relationships between microstructures and properties.The final section is dedicated to a discussion of the strengths and limitations of the phase field method,as applied to irradiation effects in nuclear materials. | Yulan Li Shenyang Hu Xin Sun Marius Stan | 2017 | npj Computational Materials2017，，1： | 6 |
| 14 | 采用电控RAM调制柴油喷射的气体燃料发动机预喷射系统显示文摘采用内部混合气形成的气体燃料发动机与采用理论配比外部混合气形成的气体燃料发动机相比,其其燃空比减少小可明显降低NOx排放。将少量柴油先喷入燃烧室使其自烯,能为由气体燃料与空气组成的主混合气建立良好的着火条件。 | Stan,C 朱晓天 | 1999 | 国外内燃机1999，31，3： | 5 |
| 15 | Giant cell tumor of the pancreas:a pathological diagnosis with poor prognosis显示文摘BACKGROUND: Giant cell tumors are rare and highly malignant tumors of the pancreas. Based on two distinct cell populations, they have been divided into two subtypes corresponding to the osteoclast-like giant cell tumor and the pleomorphic giant cell carcinoma of the pancreas. Distinctive imaging features of the tumors remain uncharacterized. Surgical removal is the only appropriate treatment for them, but responses to chemotherapy or radiotherapy remain undocumented. METHODS: Clinical, radiological, histopathologic, and immuno- histochemical features of two cases of giant cell tumor of the pancreas are presented along with a brief review of the literature. RESULTS: En-bloc resection was done successfully in both cases. The patient with an osteoclast-like giant cell tumor remained disease-free with no clinical or radiological evidence of recurrence at 6 months after surgery. However, the patient with the pleomorphic type died 4 months later due to diffuse pulmonary metastasis. CONCLUSIONS: En-bloc surgical resection is the only appropriate treatment for giant cell tumors. The overall prognosis of these tumors is poorer than that of pancreatic ductal adenocarcinoma, especially the pleomorphic type. More studies are required to document the management and outcomes of the tumors. | Ashish Singhal Stan S Shrago Vivek Kohli | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，4： | 4 |
| 16 | Thermal analysis control of in-mould and ladle inoculated grey cast irons显示文摘The effect of addition of 0.05wt.% to 0.25 wt.% Ca,Zr,Al-FeSi alloy on in-ladle and in-mould inoculation of grey cast irons was investigated.In the present paper,the conclusions drawn are based on thermal analysis.For the solidification pattern,some specific cooling curves characteristics,such as the degree of undercooling at the beginning of eutectic solidif ication and at the end of solidifi cation,as well as the recalescence level,are identif ied to be more influenced by the inoculation technique.The degree of eutectic undercooling of the electrically melted base iron having 0.025% S,0.003% Al and 3.5% Ce is excessively high(39-40℃),generating a relatively high need for inoculation.Under these conditions,the in-mould inoculation has a more signif icant effect compared to ladle inoculation,especially at lower inoculant usage(less than 0.20 wt.%).Generally,the eff iciency of 0.05wt.% -0.15wt.% of alloy for in-mould inoculation is comparable to,or better than,that of 0.15wt.% -0.25wt.% addition in ladle inoculation procedures.In order to secure stable and controlled processes,representative thermal analysis parameters could be used,especially in thin wall grey iron castings production. | Mihai Chisamera Iulian Riposan Stelian Stan Eduard Stefan George Costache | 2009 | China Foundry2009，6，2： | 4 |
| 17 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 18 | Complex(Mn,X)S compounds-major sites for graphite nucleation in grey cast iron显示文摘Despite the cubic system,the ability of sulphides to nucleate graphite can be enhanced by inoculating elements which transform them in complex compounds with a better lattice matching to graphite,a low coagulation capacity,good stability and adequate interfacial energy.(Mn,X)S compounds,usually less than 5.0μm in size,with an average 0.4-2.0μm well defined core(nucleus),were found to be important sites for graphite nucleation in grey irons.A three-stage model for the nucleation of graphite in grey irons is proposed:(1)Very small micro-inclusions based on strong deoxidizing elements(Mn,Si,Al,Ti,Zr)are formed in the melt;(2)Nucleation of complex(Mn,X)S compounds at these previously formed micro-inclusions;(3)Graphite nucleates on the sides of the(Mn,X)S compounds with lower crystallographic misfit.Al appears to have a key role in this process,as Al contributes to the formation of oxides in the first stage and favors the presence of Sr and Ca in the sulphides,in the second stage.The 0.005-0.010%Al range was found to be beneficial for lower undercooling solidification,type-A graphite formation and carbides avoidance. | Iulian Riposan Mihai Chisamera Stelian Stan Doug White | 2009 | China Foundry2009，6，4： | 4 |
| 19 | 四味镇痛中药对内腓肽降解酶作用的实验研究(英文)显示文摘目的 :研究四味镇痛中药对内腓肽降解酶的作用。方法 :从大鼠的肾脏制备含有内腓肽降解酶的物质 ,建立内腓肽降解酶活性检测模型 ;并用此模型观察四味镇痛中药提取物对内腓肽降解酶特别是对中性内肽酶活性 (NEP2 4 .11)的抑制作用。结果 :(1)钩藤和羌活的水提物显示很强的NEP2 4 11酶抑制作用 ;(2 )无论是有机提取物还是水提物 ,延胡索和川芎对NEP2 4 11的抑制作用都弱于钩藤和羌活 ;(3)钩藤和羌活不仅是氨肽酶和中性内肽酶的双重抑制剂 ,而且是氨肽酶、中性内肽酶和血管紧张素转化酶的三重抑制剂。结论 :四味镇痛中药具有不同的镇痛机制 ,其中 。 | 刘碧崇 Stan LAMBERT John BALDWIN H.EVANS | 2002 | 天然产物研究与开发2002，14，4： | 4 |
| 20 | Endothelial and platelet markers in diabetes mellitus type 2显示文摘Diabetes mellitus(DM) is an extremely common disorder which carries a risk of vascular impairment.DM type 2(DM2) can be characterized by the dysfunction of haemostasis manifesting by stimulated coagulation process,disorder of platelet function and decreased fibrinolytic activity.These all are the reasons why DM2 is the most common acquired thrombophilia.Endothelial dysfunction along with platelet hyperactivity are unquestionably involved in the hyperactivation of platelets and clotting factors in DM.As a natural consequence of continuous investigation,many markers of endothelial dysfunction and diabetic thrombocytopathy have been identified and considered for implementation in clinical practice.Endothelial function can be assessed by the evaluation of endothelial markers,circulating molecules synthesised in various amounts by the endothelium.These markers precede the signs of evident microangiopathy.Platelets have an ethiopathogenic relation to the microangiopathy in DM.Their increased activity was confirmed in both types of DM.Predictors of endothelial and platelet disorder could improve the screening of individuals at increased risk,thus leading to the early diagnosis,appropriate treatment,as well as to the effective prevention of the complications of DM2.In the article we deal with the mechanisms involved in the pathogenesis of endothelial and platelet functional abnormalities,endothelial and platelet markers of DM2 considered for implementation in clinical practice and possibilities of their detection. | Peter Kubisz Lucia Staniaková Ján Stako Peter Galajda Marián Mokáň | 2015 | World Journal of Diabetes2015，6，3： | 3 |
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