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| 1 | 云南宣威晚二叠世末生物灭绝期C1煤的地球化学特征显示文摘云南宣威雁塘煤矿晚二叠世末期C1煤层蕴含了二叠纪—三叠纪界线事件演化以及宣威肺癌高发原因方面的重要信息。本文对该矿C1煤层(包括三个分层——B1、B2和B3)进行了刻槽分层采样,采用X射线荧光光谱和电感耦合等离子体质谱测试了24个样品中常量和微量元素。利用偏光显微镜和带能谱的扫描电镜(SEMEDX)对煤中的显微组分及矿物组成进行微区分析,利用X射线衍射对低温灰化后的煤样作了矿物的半定量分析。结果表明,雁塘矿C1煤中常量元素Ca、Mn、Si含量明显高于中国煤均值;与华南二叠纪煤平均值、中国煤平均值、世界煤平均值以及地壳元素丰度相比较,雁塘矿C1煤中的W、Co、Mo、Cd、Pb、Be、Sb、Cu、Ni、Zn、Zr和V等12种微量元素相对比较富集。结合相关分析和SEM-EDX微区分析方法,对C1煤中微量元素的赋存状态进行分析发现Cs、Ga、Nb、Ba、Rb、Th、Tl、U与灰分显著正相关,表明这些元素主要以无机矿物态赋存,其它元素赋存状态复杂。结合C1煤中12种富集元素在垂向上的含量分布特征,推断Co、Cu、V、Zn应主要来源于峨眉山玄武岩风化产物;Be和Zr主要受同沉积火山灰影响;Ni则可能受峨眉山玄武岩风化及同沉积火山灰的共同影响;同沉积火山灰是C1煤中W来源之一;Sb可能受中低温热液的影响。C1煤中Zr与我国南方其他地区P/T界线粘土岩中Zr的富集规律一致。C1煤中富集的微量元素与宣威肺癌高发区可吸入颗粒物中的高含量元素一致,推断C1煤的燃烧可能与宣威肺癌高发有关。C1煤中富集的有毒有害微量元素可能与二叠纪—三叠纪之交生物大灭绝期的独特环境有密切关系。 | 邵龙义 王娟 侯海海 张名泉 汪浩 SPIRO Baruch LARGE David 周义平 | 2015 | 地质学报2015，89，1： | 17 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | SHRIMP zircon U-Pb ages from coal beds across the Permian-Triassic boundary, eastern Yunnan, southwestern China显示文摘The first SHRIMP zircon U e Pb ages from coal beds close to the end-Permian mass extinction are reported from the C_1 coal seam in the Yantang Mine in Laibin Town, Xuanwei County, eastern Yunnan Province.Zircons were extracted from kaolinite claystone layers, defined as tonsteins(volcanic ash deposits), in the subseam B_1 and B_3 of the coal seam C_1.The U-Pb ages are 252.0 ± 2.3 Ma and 250.3 ± 2.1 Ma for the sub-seam B_1 and B_3, respectively. Within analytical uncertainties, these U-Pb ages include the time period of the onset of the mass extinction at 251.941 ± 0.037 Ma, which was obtained from the marine Meishan section in Zhejiang Province, ~1600 km away from the Yantang Mine. These new ages represent not only the first and closest ages to the PTB mass extinction in terrestrial coal beds, but also ages from the nearest site to the Emeishan volcanoes investigated so far. Therefore these new data provide the most accurate stratigraphic horizon of terrestrial facies of the end-Permian extinction in South China. The Emeishan volcanoes were likely the source of volcanic ash in the coal seams at the Xuanwei County and broader areas in South China. Furthermore, the minerals and geochemistry characteristics of the C_1 coal seam also implied the influences of contemporaneous volcanic activities. | Juan Wang Long-Yi Shao Hao Wang Baruch Spiro David Large | 2018 | Journal of Palaeogeography2018，7，2： | 4 |
| 4 | The inorganic geochemistry of a peat deposit on the eastern Qinghai-Tibetan Plateau and insights into changing atmospheric circulation in central Asia during the Holocene显示文摘 | Marion Ferrat Dominik J. Weiss Baruch Spiro David Large | 2012 | Geochimica et Cosmochimica Acta2012，，： | 2 |
| 5 | Using geophysical logs to identify Milankovitch cycles and to calculate net primary productivity(NPP) of the Late Permian coals,western Guizhou,China显示文摘Milankovitch periodicities of 123 kyr(eccentricity), 35.6 kyr(obliquity), and 21.2 kyr(precession) were identified in geophysical logs of three Late Permian coals: 17#, 18#, and 17 + 18#, from the Songhe mining area in western Guizhou Province. Based on the astronomic temporal framework, the periods of deposition of the 17#(5.6 m), 18#(6.4 m), and 17 + 18#(5.4 m) coals were constrained to 140.8–119.8 kyr, 160–136.2 kyr, and 135–114.9 kyr,respectively. The overall depositional period of the 18# coal of 160–136.2 kyr was further subdivided using the wavelet analysis method, into short and precise periods corresponding to the Milankovitch periodicities. It includes one eccentricity periodicity(123 kyr), three obliquity periodicities(35.6 kyr), and five precession periodicities(21.2 kyr). Different thicknesses of the subdivided coal sections, equivalent to the same time span of deposition, indicate different rates of coal deposition, i.e., thicker sections imply higher rates while the thinner sections represent lower rates. The combination of the measured average carbon concentration with the density of the coals gave rise to long-term average values of carbon accumulation rates for the Late Permian coals, in the range of 42.4–50.6 g?C?m^(-2)?a^(-1). This range corresponds to the long-term average carbon accumulation rates for the initial peat in the range of 60.6–72.3 g?C?m^(-2)?a^(-1). Based on the known quantitative relation between net primary productivity(NPP)values and long-term average carbon accumulation rates for the Holocene tropical peatlands, the range of NPP values for the Late Permian tropical peatlands was estimated as 242.4–433.8 g?C?m^(-2)?a^(-1).A comparison of existing information about peatland NPP levels of various ages and latitudes indicated that when conditions of high rain and high humidity prevail in the palaeo-peatland at given latitude, the NPP rates will vary with changes in atmospheric concentration of CO_2 and O_2. This relationship may lead to the use of coals as an indicator for the concentration of these gases(CO_2 and O_2) in the contemporaneous atmosphere encompassing the long records of coal deposition. | Zhi-Ming Yan Long-Yi Shao David Large Hao Wang Baruch Spiro | 2019 | Journal of Palaeogeography2019，8，1： | 2 |
| 6 | Radio Transmission to and from Un- derground Coal Mines: Theory and Measurement 显示文摘 | David B Large Lawrence B | 1973 | IEEE Transactions on Communications1973，21，3： | 1 |
| 7 | Venture capitalists' non-financial valueadded:an evaluation of the evidence and implications for research显示文摘 | David Large Steven Muegge | | 0，，01： | 1 |
| 8 | Building Successful Technology Commercialization Teams:Pilot Empirical Support for the Theory of Cascading Commitment显示文摘 | David Large Keith Belinko Katerina Kalligatsi | 2004 | The Journal of Technology Transfer2004，，2： | 1 |
| 9 | Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain显示文摘 | David Borsook Jaymin Upadhyay Michael Klimas Adam J. Schwarz Alexandre Coimbra Richard Baumgartner Edward George William Z. Potter Thomas Large David Bleakman Jeffrey Evelhoch Smriti Iyengar Lino Becerra Richard J. Hargreaves | 2012 | Drug Discovery Today (-)2012，，17： | 1 |
| 10 | The distribution of trace elements and Sr isotopes across the coal and its partings in the Wyodak sea, Powder River Basin, Wyoming, USA显示文摘 | Baruch F. Spiro Margaret Gomnge David J Large Chris Somerfield | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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