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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Pediatric liver transplantation显示文摘In previous decades,pediatric liver transplantation has become a state-of-the-art operation with excellent success and limited mortality.Graft and patient survival have continued to improve as a result of improvements in medical,surgical and anesthetic management,organ availability,immunosuppression,and identification and treatment of postoperative complications.The utilization of split-liver grafts and living-related donors has provided more organs for pediatric patients.Newer immunosuppression regimens,including induction therapy,have had a significant impact on graft and patient survival.Future developments of pediatric liver transplantation will deal with long-term followup,with prevention of immunosuppression-related complications and promotion of as normal growth as possible.This review describes the state-of-the-art in pediatric liver transplantation. | Marco Spada Silvia Riva Giuseppe Maggiore Davide Cintorino Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 20 |
| 3 | 儿童急性呼吸窘迫综合征的治疗进展(英文)显示文摘急性呼吸窘迫综合征(ARDS)是一种具有复杂病理和发病机制的异质性综合征,目前仍没有一个明确和有效的治疗对策。根据低氧血症程度,ARDS分成三类:轻度(200mmHg〈氧合指数≤300mmHg)、中度(100mmHg〈氧合指数≤200mmHg)、严重(氧合指数≤100mmHg)。治疗ARDS的基础是正确的重症监护治疗。早期管理可以改善预后,避免副作用和并发症,并提高存活率。治疗诱因(如败血症、肺炎),最大限度地减少多器官功能衰竭(MOF)、功能障碍和呼吸机相关性肺损伤(VILI)的风险在治疗过程中是至关重要的。 | Giuseppe A. Marraro Chengshui Chen Maria Antonella Piga Yan Qian Claudio Spada Umberto Genovese1 | 2014 | 中国当代儿科杂志2014，16，5： | 19 |
| 4 | Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs显示文摘For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results. | Joel da Cunha Luciana Morganti Ferreira Maselli Ana Carolina Bassi Stern Celso Spada Sérgio Paulo Bydlowski | 2015 | World Journal of Virology2015，4，2： | 9 |
| 5 | Capsule endoscopy in celiac disease显示文摘Video capsule endoscopy is an attractive and patient- friendly tool that provides high quality images of the small bowel. Obscure gastrointestinal bleeding is the primary and most evaluated indication to capsule endoscopy;however,indications are expanding and a small number of preliminary reports have been presented concerning the role of video capsule endoscopy in the diagnosis of celiac disease. The purpose of this review is to update the current knowledge and to hypothesize on future perspectives of the use of video capsule endoscopy in patients with celiac disease. | Cristiano Spada Maria Elena Riccioni Riccardo Urgesi Guido Costamagna | 2008 | World Journal of Gastroenterology2008，14，26： | 8 |
| 6 | 冒号囊内视镜检查法: 优点,限制和期望哪个新奇?显示文摘 Since the first reports almost ten years ago, wireless capsule endoscopy has gained new f ields of application. Colon capsule endoscopy represents a new diagnostic technology for colonic exploration. Clinical trials have shown that colon capsule endoscopy is feasible, accurate and safe in patients suffering from colonic diseases and might be a valid alternative to conventional colonoscopy in selected cases such as patients refusing conventional colonoscopy or with contraindications to colonoscopy or when colonoscopy is incomplete. Despite the enthusiasm surrounding this new technique, few clinical and randomized controlled trials are to be found in the current literature, leading to heterogeneous or controversial results. Upcoming studies are needed to prove the substantial utility of colon capsule endoscopy for colon cancer screening, especially in a low prevalence of disease population, and for other indications such as inflammatory bowel disease. Possible perspectives are critically analysed and reported in this paper. | Maria Elena Riccioni Riccardo Urgesi Rossella Cianci Alessandra Bizzotto Cristiano Spada Guido Costamagna | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 7 |
| 7 | Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | C. Hassan M. Bretthauer M. Kaminski M. Polkowski B. Rembacken B. Saunders R. Benamouzig O. Holme S. Green T. Kuiper R. Marmo M. Omar L. Petruzziello C. Spada A. Zullo J. Dumonceau | 2013 | Endoscopy2013，，02： | 7 |
| 8 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 9 | 新型冠状病毒肺炎儿童重症急性呼吸衰竭的呼吸支持策略建议显示文摘最近,一种新型冠状病毒(命名为SARSCoV-2)引起的重症肺炎在中国暴发流行,造成了一场全球公共卫生机构高度戒备的紧急状态。SARSCoV-2感染的特点是在最初的发热和咳嗽后迅速演变成严重甚至致命的呼吸衰竭,类似于急性呼吸窘迫综合征(ARDS)。在大多数情况下,可以通过常规的对症治疗痊愈,但严重者要入住重症监护病房(ICU),这类患者病死率很高[4-6]。 | Giuseppe A Marraro Claudio Spada 王霞(译) | 2020 | 中国当代儿科杂志2020，22，3： | 4 |
| 10 | Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients显示文摘AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF. METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviraltherapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used. RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ 2M H = 4, P < 0.04). In fact, LS ≥ 9.5 was significantly higher in co-infected than in HIV and HCV mono-infected pa-tients (χ 2 = 5, P < 0.03). Also APRI and the FIB-4 index showed more LF in co-infected than in HIV mono-infect-ed patients (P < 0.0001), but not in HCV mono-infected patients. In HIV?HCV co-infected patients, the extent of LS was significantly associated with alcohol intake (P < 0.04) and lower CD4+ cell count (P < 0.02). In HCV pa-tients, LS was correlated with alcohol intake (P < 0.001) and cholesterol levels (P < 0.03). Body mass index, dia-betes, HCV-and HIV-viremia were not significantly cor-related with LS. In addition, 20% of co-infected patients had virologically unsuccessful HAART; in 50% compliance was low, CD4+ levels were < 400 cells/mm 3 and LS was > 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues. CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protective immunological effects of HAART on LF progression outweigh its hepatotoxic effects. | Valentina Li Vecchi Maurizio Soresi Claudia Colomba Giovanni Mazzola Pietro Colletti Maurizio Mineo Paola Di Carlo Emanuele La Spada Giovanni Vizzini Giuseppe Montalto | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 11 | De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature显示文摘BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer. | Tommaso Maria Manzia Roberta Angelico Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi | 2019 | World Journal of Gastroenterology2019，25，35： | 3 |
| 12 | Second-generation colon capsule endoscopy is feasible in the out-of-clinic setting显示文摘 | Samuel Nathan Adler Cesare Hassan Yoav Metzger Yishai Sompolinsky Cristiano Spada | 2014 | Surgical Endoscopy2014，，2： | 3 |
| 13 | Early graft dysfunction following adult-to-adult livingrelated liver transplantation:Predictive factors and outcomes显示文摘AIM:To describe a condition that we define as early graft dysfunction(EGD)which can be identified preoperatively. METHODS:Small-for-size graft dysfunction following living-related liver transplantation(LRLT)is characterized by EGD when the graft-to-recipient body weight ratio(GRBWR)is below 0.8%.However, patients transplanted with GRBWR above 0.8%can develop dysfunction of the graft.In 73 recipients of LRLT(GRBWR>0.8%),we identified 10 patients who developed EGD.The main measures of outcomes analyzed were overall mortality,number of re-transplants and length of stay in days(LOS).Furthermore we analyzed other clinical pre-transplant variables,intraoperative parameters and post transplant data.RESULTS:A trend in favor of the non-EGD group(3-mo actuarial survival 98%vs 88%,P=0.09;3-mo graft mortality 4.7%vs 20%,P=0.07)was observed as well as shorter LOS(13 d vs 41.5 d;P=0.001)and smaller requirement of peri-operative Units of Plasma (4 vs 14;P=0.036).Univariate analysis of pre- transplant variables identified platelet count,serum bilirubin,INR and Meld-Na score as predictors of EGD. In the multivariate analysis transplant Meld-Na score (P=0.025,OR:1.175)and pretransplant platelet count(P=0.043,OR:0.956)were independently associated with EGD. CONCLUSION:EGD can be identified preoperatively and is associated with increased morbidity after LRLT. A prompt recognition of EGD can trigger a timely treatment. | Salvatore Gruttadauria Fabrizio di Francesco Giovanni Battista Vizzini Angelo Luca Marco Spada Davide Cintorino Sergio Li Petri Giada Pietrosi Duilio Pagano Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，36： | 2 |
| 14 | MDCT, MR and interventional radiology in biliary atresia candidates for liver transplantation显示文摘The multi-detector computed tomography (MDCT) scan and magnetic resonance (MR) of the abdomen play a key role in the work-up to liver transplantation (LT) by identifying congenital anomalies or cirrhosis-related modifications, conditions that can require changes in surgical technique. Moreover, the MDCT and MR scans allow identification of cirrhotic liver hepatic masses, extrahepatic porto-systemic shunts, eventual thrombosis of portal system and radiological signs of portal hypertension associated with biliary atresia (BA). The aim of this paper is to review MDCT, MR imaging and interven-tional radiology procedures performed to evaluate morphological changes and degree of portal hypertension in pediatric patients with end-stage liver disease secondary to BA, who are candidates for LT. Advances in the field of MR, MDCT and in percutaneous minimally invasive techniques have increased the importance of radiology in the management of pediatric patients with BA who are candidates for LT. | Roberto Miraglia Settimo Caruso Luigi Maruzzelli Marco Spada Silvia Riva Marco Sciveres Angelo Luca | 2011 | World Journal of Radiology2011，3，9： | 2 |
| 15 | Combined endoscopic stent insertion in malignant biliary and duodenal obstruction显示文摘 | M. Mutignani A. Tringali S. Shah V. Perri P. Familiari F. Iacopini C. Spada G. Costamagna | 2007 | Endoscopy2007，，： | 2 |
| 16 | Colon capsule endoscopy:What we know and what we would like to know显示文摘Colonoscopy is usually perceived as an invasive and potentially painful procedure,being also affected by a small,but definite,risk of major complications(cardiopulmonary complications,perforation,hemorrhage)and even mortality.To improve both acceptability and safety,Pill Cam Colon Capsule Endoscopy(CCE)(Given Imaging Ltd,Yoqneam,Israel)has been developed.CCE represents a non-invasive technique that is able to explore the colon without sedation and air insufflation.The Second Generation of Colon Capsule Endoscopy(Pill Cam Colon 2)(CCE-2)was proven to be an accurate tool to detect colonic neoplastic lesions when used in average risk individuals.To date,the evidence supports the use of CCE-2 in case of colonoscopy failure,in patients unwilling to perform colonoscopy and when colonoscopy is contraindicated.Other potential applications,such as colorectal cancer screening or diagnostic surveillance ofinflammatory bowel disease need to be clarified.In this paper,the current'state of the art',potential application of CCE and future needs are evaluated. | Cristiano Spada Federico Barbaro Gianluca Andrisani Leonardo Minelli Grazioli Cesare Hassan Isabella Costamagna Mariachiara Campanale Guido Costamagna | 2014 | World Journal of Gastroenterology2014，20，45： | 2 |
| 17 | Tulip bundle technique and fibrin glue injection:Unusual treatment of colonic perforation显示文摘We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon. | Filippo Mocciaro Gabriele Curcio Ilaria Tarantino Luca Barresi Marco Spada Sergio Li Petri Mario Traina | 2011 | World Journal of Gastroenterology2011，17，8： | 2 |
| 18 | Liver regeneration after liver resection: Clinical aspects and correlation with infective complications显示文摘AIM:To investigate whether early liver regeneration after resection in patients with hepatic tumors might be influenced by post-operative infective complications.METHODS:A retrospective analysis of 27 liver resections for tumors performed in a single referral center from November 2004 to January 2010.Regeneration was evaluated by multidetector computed tomographyat a mean follow-up of 43.85 d.The Clavien-Dindo classification was used to evaluate postoperative events in the first 6 mo after transplantation,and Centers for Disease Control and Prevention definitions were used for healthcare associated infections data.Generalized linear regression models with Gaussian family distribution and log link function were used to reveal the principal promoters of early liver regeneration.RESULTS:Ten of the 27 patients(37%)underwent chemotherapy prior to surgery,with a statistically significant prevalence of patients with metastasis(P=0.007).Eight patients(30%)underwent embolization,3 with primary tumors,and 5 with secondary tumors.Twenty patients(74%)experienced complications,with 12(60%)experiencing Clavien-Dindo Grade 3a to 5 complications.Regeneration≥100%occurred in 10(37%)patients.The predictors were smaller future remnant liver volume(-0.002;P<0.001),and a greater spleen volume/future remnant liver volume ratio(0.499;P=0.01).Patients with a resection of≥5 Couinaud segments experienced greater early regeneration(P=0.04).Nine patients experienced surgical site infections,and in 7 cases Clavien-Dindo Grade 3a to 4 complications were detected(P=0.016).There were no significant differences between patients with primary or secondary tumors,and either onset or infections or severity of surgical complications.CONCLUSION:Regardless of the onset of infective complications,future remnant liver and spleen volumes may be reliable predictors of early liver regeneration after hepatic resection on an otherwise healthy liver. | Duilio Pagano Marco Spada Vishal Parikh Fabio Tuzzolino Davide Cintorino Luigi Maruzzelli Giovanni Vizzini Angelo Luca Alessandra Mularoni Paolo Grossi Bruno Gridelli Salvatore Gruttadauria | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 19 | Long-term outcome of pancreatic function following oncological surgery in children:Institutional experience and review of the literature显示文摘BACKGROUND Pancreatic neoplasms are uncommon in children and in most cases they are benign or have low malignant potential.Pancreatoblastoma and solid pseudopapillary tumor are the most frequent types in early and late childhood,respectively.Complete resection,although burdened by severe complications,is the only curative treatment for these diseases.Pancreatic surgery may result in impaired exocrine and endocrine pancreatic function.However,limited data are available on the long-term pediatric pancreatic function following surgical resection.AIM To investigate endocrine and exocrine pancreatic function and growth after oncological pancreatic surgery in a pediatric series.METHODS A retrospective analysis of all pediatric patients who underwent surgery for pancreatic neoplasm in our Institution from January 31,2002 to the present was performed.Endocrine and exocrine insufficiency,auxological and fat-soluble vitamin status(A,D,E and clotting tests)were assessed at diagnosis and at every follow-up visit.Exocrine insufficiency was defined as steatorrhea with fecal elastase-1<200μg/g stool,while endocrine insufficiency was identified as onset of Diabetes or Impaired Glucose Tolerance.Growth was evaluated based on body mass index(BMI)z-score trend.RESULTS Sixteen patients(12 girls and 4 boys,mean age 10.7±5.3 years),were included.Nine patients(56%)had a neoplasm in the pancreatic head,4 in the body/tail,2 in the tail and 1 in the body.Histological findings were as follows:Solid pseudopapillary tumor in 10 patients(62.5%),insulinoma in 2 patients,neuroendocrine tumor in 2 patients and acinar cell carcinoma in 2 patients.The most frequent surgery was pancreaticoduodenectomy(50%).Exocrine failure occurred in 4 patients(25%)and endocrine failure in 2 patients(12.5%).Exocrine insufficiency occurred early(within 6 mo after surgery)and endocrine insufficiency later(8 and 10 years after surgery).Mean BMI z-score was 0.36±1.1 at diagnosis and 0.27±0.95 at the last assessment.Vitamin D was insufficient(<30 ng/mL)in 8 of the 16 patients during the follow-up period.Vitamins A,E and clotting test were into the normal ranges in all patients.CONCLUSION Careful and long-term monitoring should follow any pancreatic surgery,to recognize and promptly treat exocrine and endocrine pancreatic insufficiency,which can occur after surgery. | Giulia Bolasco Teresa Capriati Chiara Grimaldi Lidia Monti Maria Debora De Pasquale Ippolita Patrizia Patera Marco Spada Giuseppe Maggiore Antonella Diamanti | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 20 | Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis显示文摘 | Haruya Ishiguro Shoichi Saito Hiroo Imazu Hiroyuki Aihara Tomohiro Kato Hisao Tajiri Cristiano Spada | 2011 | Gastroenterology Research and Practice2011，，： | 2 |
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