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| 1 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 2 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 3 | A double-blind,placebo-controlled,dose-response study of the effectiveness and safety of lisinopril for children with hypertension显示文摘 | SOFFER B ZHANG Z MILLER K | 2003 | Am J Hypertens2003，16，10： | 1 |
| 4 | Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-induced angiogenesis显示文摘 | Itin A Soffer D | 1992 | Nature1992，359，： | 1 |
| 5 | Comparative analysis of cerebrovascular resistance in fetuses with single‐ventricle congenital heart disease显示文摘 | A. Szwast Z. Tian M. McCann D. Soffer J. Rychik | 2012 | Ultrasound Obstet Gynecol2012，，1： | 1 |
| 6 | Water desalting by means of electrochemical parametric pumping显示文摘 | Y. Oren A. Soffer | 1983 | Journal of Applied Electrochemistry1983，，4： | 1 |
| 7 | The imemet and national solidarity: A theoretical analysis显示文摘 | SOFFER O | 2013 | Communication Theory2013，23，： | 1 |
| 8 | The outcome of intracytoplasmic injection of fresh and cryopreserved epididymal spermatozoa from patients with obstructive azoospermia:a comparative study 显示文摘 | Friedler S Raziel A Soffer Y | 1998 | Hum Reprod1998，13，： | 1 |
| 9 | Vascular endothelial growth factor induced by hypoxia maymediate hypoxia-initiated angiogenesis显示文摘 | Shweiki D Itin A Soffer D | 1993 | Nature(Lond)1993，359，： | 1 |
| 10 | Eradication of small intestinal bacterial overgrowth reduced symptoms of irritable bowel syndrome显示文摘 | Pimental M Soffer EE Chow EJ | 2002 | Dig Dis Sci2002，47，12： | 1 |
| 11 | Adver effects of laxatives显示文摘 | Qing JH Soffer EE | 2001 | Dis Colon Rectum2001，44，8： | 1 |
| 12 | Laparoscopic inguinal hernia inversion and ligation in female children:a review of 173 consecutive cases at a single institution显示文摘 | Lipskar AM Soffer SZ Glick RD | | 0，，06： | 1 |
| 13 | Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis 显示文摘 | SWEIKI D ITIN A SOFFER D | 1992 | Nature1992，359，： | 1 |
| 14 | Teaching ultrasound-guided interscalene blocks:description of a simple and effective technique显示文摘 | Soffer RJ Rosenblatt MA | 2007 | J Clin Anesth2007，19，3： | 1 |
| 15 | Resistance of a VEGF-producing tumor to anti-VEGF antibody:unimpeded growth of human rhabdoid tumor xenografts显示文摘 | Soffer SZ Kim E Huang J | 2002 | J Pediatr Surg2002，37，： | 1 |
| 16 | Ovarian hyperstimulation syndrome: an update review显示文摘 | Golan A Ronel R Soffer Y | 1989 | Obstet Gynecol Survey1989，44，： | 1 |
| 17 | 查看详情显示文摘 | Koresh J.E Soffer A | | 0，，： | 1 |
| 18 | VaseuIar endothelial growth factor induced by hypoxia may mediate hypoxia initiated angiogenesis显示文摘 | Shweiki D Itin A Soffer D | 1992 | Nature1992，359，6398： | 1 |
| 19 | Distinct response of experimental neuroblastoma to combination antiangiogenic strategies显示文摘 | Kim ES Soffer SZ Huang J | 2002 | J Pediatr Surg2002，37，3： | 1 |
| 20 | MARCO: MAP retrieval by content 显示文摘 | SAMET H SOFFER A | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，，： | 1 |
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