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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Sperm defect severity rather than sperm source is associated with lower fertilization rates after intracytoplasmic sperm injection显示文摘 | Verza SJr Esteves SC | 2008 | Int Braz J Urol2008，34，1： | 1 |
| 3 | Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration 显示文摘 | Brown GC Bolanos JP Heals SJR | 1995 | Neurosic Lett1995，193，3： | 1 |
| 4 | Postharvestpericaqpbrowning of lychee (Litchi chinensis Sonn) fruit显示文摘 | Underhill SJR Critchley C Simons DH | | 0，，： | 1 |
| 5 | Anthocyanin declorisation and itsrole in lychee pericarp browning显示文摘 | Underhill SJR -Critchley C | | 0，，01： | 1 |
| 6 | Steatotic livers are susceptible to normothermic ischemiareperfusion injury from mitochondrial Complex-Ⅰ?dysfunction显示文摘AIM: To assess the effects of ischemic preconditioning(IPC, 10-min ischemia/10-min reperfusion) on steatotic liver mitochondrial function after normothermic ischemia-reperfusion injury(IRI).METHODS: Sixty male Sprague-Dawley rats were fed8-wk with either control chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IRI group underwent 60 min partial hepatic ischemia and 4 h reperfusion;(2) the IPC group underwent IPC prior to same standard IRI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I R I o r I P C. H e p a t i c mitochondrial function was analyzed by oxygraphs. Mitochondrial Complex-Ⅰ, Complex-Ⅱ enzyme activity, serum alanine aminotransferase(ALT), and histological injury were measured.RESULTS: Steatotic-IRI livers had a greater increase in ALT(2476 ± 166 vs 1457 ± 103 IU/L, P < 0.01) and histological injury following IRI compared to the lean liver group. Steatotic-IRI demonstrated lower Complex-Ⅰ?activity at baseline [78.4 ± 2.5 vs 116.4 ± 6.0 nmol/(min.mg protein), P < 0.001] and following IRI [28.0 ± 6.2 vs 104.3 ± 12.6 nmol/(min.mg protein), P < 0.001]. Steatotic-IRI also demonstrated impaired Complex-Ⅰ?function post-IRI compared to the lean liver IRI group. Complex-Ⅱ activity was unaffected by hepatic steatosis or IRI. Lean liver mitochondrial function was unchanged following IRI. IPC normalized ALT and histological injury in steatotic livers but had no effect on overall steatotic liver mitochondrial function or individual mitochondrial complex enzyme activities. CONCLUSION: Warm IRI impairs steatotic liver Complex-Ⅰ?activity and function. The protective effects of IPC in steatotic livers may not be mediated through mitochondria. | Michael JJ Chu Rakesh Premkumar Anthony JR Hickey Yannan Jiang Brett Delahunt Anthony RJ Phillips Adam SJR Bartlett | 2016 | World Journal of Gastroenterology2016，22，19： | 1 |
| 7 | Insulin-like growth factor I as a cardiac hormone:physiological and pathophysiological implications in heart disease显示文摘 | Ren J Willis K Sowers SJR | 1999 | Mol Cell Cardiol1999，31，： | 1 |
| 8 | Treatment selection and outcomes: ureteral cal-culi显示文摘 | WOLFJ SJr | 2007 | Urol Clin North Am2007，34，： | 1 |
| 9 | Renal fascia pathway:posterior extension of pancreatic effusions within the anterior pararenal space显示文摘 | Raptopoulos V Kleinman PK Marks SJr | 1986 | Radiology1986，158，2： | 1 |
| 10 | Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension显示文摘 | Tunariu N Gibbs SJR Win Z | | Journal of Nuclear Medicine0，，： | 1 |
| 11 | American Society of Clinical On- eology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer 显示文摘 | Azzoli CG Baker SJr Temin S | 2009 | J Clin 0neol2009，27，36： | 1 |
| 12 | Patient satisfaction and outcome after microfracture of the degenerative knee 显示文摘 | Miller BS SJR Briggs KK RJJ Rodkey WG | 2004 | J Knee Surg2004，，17： | 1 |
| 13 | 显示文摘 | Bolanos JP Heales SJR Peuchen S | 1996 | Free Radic Biol Med1996，21，： | 1 |
| 14 | Hypervascularliver tumors, low tube voltage, high tube current multi -detector row CT for enbanced detection-phantom study显示文摘 | Schindera ST Nelson RC Mukundan SJr | 2008 | Radiology2008，246，1： | 1 |
| 15 | The effect of HMG-CoA reductase inhibitors on coenzyme Q10显示文摘 | HARGREAVES IP DUNCAN AJ HEALES SJR | 2005 | Drug Saf2005，28，8： | 1 |
| 16 | Reestablishing biologic width with forced eruption 显示文摘 | Felippe LA Monteiro SJr Vieira LC | 2003 | Quintessence Int2003，34，10： | 1 |
| 17 | Oral leukoplakia and malignant transformation:A follow-up study of 257 patients显示文摘 | Gorsky M Lozada F | 1984 | Cancer1984，53，： | 1 |
| 18 | A review of accelerated carbonation technology in the treatment of cement-based materialsand sequestration of CO2 显示文摘 | Bertos FM Simons SJR Hills CD Carey PJ | 2004 | J Hazard Mater2004，12，3： | 1 |
| 19 | The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery显示文摘 | Zada G Agarwalla PK Mukundan SJr | | 0，，05： | 1 |
| 20 | Apoptosisassociated proteins and the developmet of oral squamous cell carcinoma 显示文摘 | Schoelch ML Le QT Silverman SJr | 1999 | Oral Oncol1999，35，1： | 1 |
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