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| 1 | 戒烟与复吸影响因素及戒烟者健康状况分析显示文摘目的揭示戒烟水平、戒烟与复吸原因、成功戒烟的影响因素及与其健康状况的关系,为在中国提出更有针对性的控烟对策提供参考。方法利用两次具有全国代表性的中国国家卫生服务调查数据,采用分组分析、logistic回归分析、年龄标准化等方法分析戒烟相关指标和影响因素。结果2003年只有6.1%的戒烟率,7.9%的正在吸烟者有戒烟意愿,老年吸烟者、城市地区、高收入者、患有慢性病者或自感健康较差者比较容易戒烟成功,而户中有多名吸烟者、经常饮酒者不易戒烟成功;戒烟者本身健康状况已较差;54%的复吸者报告是因为'控制不住烟瘾',约29%的人是因为社交或社会环境影响而复吸。结论中国吸烟者的戒烟水平和意愿均较低、因病而戒烟表明戒烟太晚太被动;除现有控烟政策外,更有针对性的控烟活动如对年轻吸烟者、农村地区吸烟者、多吸烟者住户和促进未病先戒等活动也是迫切需要的。 | 钱军程 饶克勤 高军 Julia Critchley 汤胜蓝 蔡敏 | 2009 | 中国卫生统计2009，26，2： | 34 |
| 2 | 黄芪总黄酮对扑热息痛所致小鼠肝损伤防护作用的研究显示文摘目的 :研究黄芪总黄酮 (TFA)对扑热息痛所致肝损伤的防护作用。方法 :用 1%羧甲基纤维素钠 10ml·kg-1,TFA10 0mg·kg-1或维生素C (Ascorbicacid ,VC) 10 0 0mg·kg-1给小鼠灌胃 1h后 ,灌扑热息痛 10 0 0mg·kg-1,观察小鼠死亡率的变化 ;提前 1h用不同剂量的TFA或VC处理后 ,再灌 40 0mg·kg-1的扑热息痛 ,检测血清酶学和肝脏组织学的改变。结果 :给小鼠扑热息痛 10 0 0mg·kg-1灌胃组 ,2 4h后可致 80 %小鼠死亡 ;提前 1h用TFA10 0mg·kg-1或VC灌胃其死亡率可分别下降至 2 0 %和 0 %。血清转氨酶 (ALT)和病理切片显示当给 40 0mg·kg-1扑热息痛灌胃 2 4h后即可引起严重肝损伤 (ALT升高和肝组织大面积坏死 ,P <0 .0 0 1)。TFA或VC预防组 (提前 1h给药 )的肝损伤程度与对照组比较明显减轻 ,其作用强度与药物浓度成正比。结论 :TFA对扑热息痛所致肝损伤有保护作用。 | 汪德清 丁保国 马艳青 赵海潞 Thomas G Neil Tomlinson Brian 田亚平 王成彬 Critchley Julian AJH | 2001 | 中国中药杂志2001，26，7： | 31 |
| 3 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 4 | 在有类型 2 糖尿病的病人的 nephropathy 的管理。 | Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC Cockram CS | 2002 | Chinese Medical Journal2002，，1： | 12 |
| 5 | 阿托伐他汀对高脂血症患者血小板聚集反应的影响显示文摘观察降血脂药阿托伐他汀作用于高脂血症患者的血小板聚集反应。测试全血血小板聚集对各种诱导剂的反应性及实验的重复性 ,并选择胶原作为诱导剂进行全血血小板聚集反应检测。 30个高脂血症患者接受为期16周的治疗 ,用药剂量递增 ,从每日用药 10、2 0、40mg ,到 80mg ,均分别用药 4周 ,直至患者血脂水平达到靶水平以下。分别在最大剂量用药期及停药后 4周检测患者的血小板聚集反应、血小板计数、平均血小板体积、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯水平。总胆固醇、低密度脂蛋白胆固醇及甘油三酯水平在停药后显著回升 (5 .0± 1.1、3.0± 1.0、2 .2± 3.3mmol/L比 9.0± 3.1、6 .8± 1.5、5 .0± 12 .4mmol/L ,P <0 .0 0 1)。与停药后 4周相比 ,在最大剂量用药期 ,患者全血血小板聚集反应显著降低 (自 19.0± 3.1Ω降至 17.1± 4.6Ω ,P <0 .0 5 ) ,而高密度脂蛋白胆固醇、血小板计数及平均血小板体积不受影响。表明阿托伐他汀能有效降低高脂血症患者的血脂水平及改善血小板聚集功能。 | 范伯丽 程颖 房家智 蒋宝琦 GNeil Thomas Julian AJH Critchley Brian Tomlinson | 2003 | 中国动脉硬化杂志2003，11，5： | 12 |
| 6 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 7 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 8 | 依托孕烯避孕用皮下植入剂使用者出现不可接受出血模式时的处理方法显示文摘本文旨在对依托孕烯(ENG)皮下植入避孕剂使用者不可接受出血模式的处理进行综述,其重点是探究药物治疗如可能有证据以及未找到证据的情况下寻求实用的处理方法。本文是按英国皇家妇产科医师学院绿皮指导原则的要求撰写而成。在Cochrane文库(包括系统综述,DARE和EMBASE的Cochrane数据库)和Medline(1966-2010)中,用相关MeSH术语,包括所有副标题进行检索,并与关键词检索相结合。检索关键词包括"单孕激素避孕方法"、"避孕用皮下植入剂"、"孕激素皮下植入剂"、"依托孕烯皮下植入剂"、"不规则出血"、"不可预测的出血"、"出血不规则"、"出血模式",检索限于人体研究和英语文献。对研究中缺乏的信息也向相关的制药企业和研究人员进行了查询。虽然这不是一篇系统综述,但其中两位作者(Diana Mansour,Ian S.Fraser)对报道治疗相关的定量结果的论文进行了定性评价。这些论文涉及的治疗方法用于中止或者预防依托孕烯或左炔诺孕酮皮下植入剂使用者的出血。 | Diana Mansour Luis Bahamondes Hilary Critchley Philip Darney Ian S.Fraser | 2014 | 生殖医学杂志2014，23，6： | 3 |
| 9 | 吸烟致贫及对贫困户卫生服务需要和利用影响的研究显示文摘吸烟能导致癌症、心血管疾病及呼吸系统疾病并引发早死,对健康的危害很明确,而吸烟与贫困的关系、与卫生服务需要和利用关系的研究相对较少。减少贫困是社会发展的目标之一,而贫困的产生有各种各样的原因,笔者欲从已引起国际社会关注的吸烟与贫困的关系,阐述吸烟对不同收入人群的直接致贫情况,比较贫困吸烟住户与贫困非吸烟住户在2周患病、应就诊未就诊、 | 钱军程 高军 Julia Critchley 汤胜蓝 陈育德 | 2008 | 中华预防医学杂志2008，42，11： | 3 |
| 10 | The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients显示文摘 | MA Y Q THOMAS G N CRITCHLEY J A | 2003 | Metabolism2003，52，3： | 2 |
| 11 | Short-term postural reflexes in diabetic patients with autonomic dysfunction 显示文摘 | ZHANG Y CRITCHLEY L A TAM Y H TOMLINSON B | 2004 | Diabetologia2004，47，： | 1 |
| 12 | Factor analysis of the metabolic syndrome:obesity vs insulin resistance as the central abnormality 显示文摘 | Anderson P J Critchley JA Chan Jc | 2001 | Int J Obes Relat Metab Disord2001，25，12： | 1 |
| 13 | Human fallopi- an tube epithelium constitutively expresses integrin endo- metrial receptivity markers: no evidence for a tubal im- plantation window显示文摘 | Brown J K Shaw J L Critchley H O | 2012 | Mol Hum Reprod2012，18，3： | 1 |
| 14 | Fentanyl dose-response curves when inserting the LMA Classic^TM laryngeal mask airway 显示文摘 | Wong C M Critchley L A Lee A | 2007 | Anaesthesia2007，62，7： | 1 |
| 15 | Hormone receptor dynamics in a receptive human endometrium显示文摘 | Critchley HO Saunders PT | 2009 | Reprod Sci2009，16，2： | 1 |
| 16 | Neural activityrelating to generation and representation of galvanic skin conductante responses:a functional magnetic resonance imaging study显示文摘 | Critchley HD Elliott R Mathias CJ | 2000 | Neurosci2000，20，2： | 1 |
| 17 | A randomized ,double-masked comparison of the anti-hypertensive efficacy and safety of combination therapy with losartan and hydrochlorothiazide versus captopril and hydrochlorothiazide in elderly and younger patients 显示文摘 | Critchley J | 1996 | Cur Therapeutic Res1996，57，： | 1 |
| 18 | Current knowledge of the aetiology of human tubal eetopic pregnancy显示文摘 | Shaw J L Dey S K Critchley H O | 2010 | Hum Reprod Update2010，16，4： | 1 |
| 19 | Distribution and symptoms of epiphyte infection in major carrageenophyte-producing farms显示文摘 | Vairappan CS Chung C Hurtado A Soya F Lhonneur G & Critchley A | 2008 | J Appl Phycol2008，20，47： | 1 |
| 20 | Nitrogen transfer within and between plants through common mycorrhizal networks 显示文摘 | He X H Critchley C Bledsoe C | 2003 | Plant Sci2003，22，6： | 1 |
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