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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Phase formation in YAG powder synthesized by chemical methods 显示文摘 | SIM S M KELLER K A | 2000 | J Mater Sci2000，35，： | 2 |
| 3 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 4 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 5 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 6 | Genome-wide association study of ankylosing spondylifts identifies nonMHC susceptibility loci显示文摘 | Reveille J D Sims A M Danoy P | | 0，，2： | 1 |
| 7 | Hypertension is associated with serologically active disease in patients with systemic lupus erythematosus:role of increased Th1/Th2ratio and oxidative stress显示文摘 | Lozovoy M A Simo A N Morimoto H K | 2014 | Scand J Rheumatol2014，43，1： | 1 |
| 8 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 9 | Supercritical carbon dioxide extraction efficiency for carotenes from carrots by RSM显示文摘 | Balaban M O Sims C A | 1996 | Journal of Food Science1996，61，75： | 1 |
| 10 | The effect of Prostag l andin E1 incorporated in lipid microsphere on thrombus formation and thrombus disaggregation and its potential to tar get to the site of vascrlar lesions显示文摘 | Sim A McCraw A Cleland M | 1986 | Drug Res1986，36，： | 1 |
| 11 | The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity显示文摘 | Mushtaq A Payton M Sim E | 2002 | J Biol Chem2002，277，12： | 1 |
| 12 | Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes显示文摘 | M(a)nnikk(o) R Flanagan SE Sim X | | 0，，06： | 1 |
| 13 | Job Stressors and Satisfaction in the Nursing Staff of a Critical Unit显示文摘 | Simón M G Blesa A M Bermejo P C | 2005 | Enferm Intensiva2005，16，1： | 1 |
| 14 | Influence of cytochrome P450 polymorphisms on drug therapies:pharmacogenetic, pharmacoepigenetic and clinical aspects显示文摘 | Ingelman-Sundberg M Sim SC Gomez A | 2007 | Pharmacol Ther2007，116，3： | 1 |
| 15 | Electrochemical behaviour of a Mg-rich primer in the protection of Alalloys 显示文摘 | Battocchi D Sim?es A M Tallman D E Bierwagen G P | 2006 | Corrosion Science2006，48，5： | 1 |
| 16 | Optimization of carrot Juice color and cloud stability显示文摘 | Sims C A Balaban M O Matthews R F | 1993 | J Food Sci1993，58，： | 1 |
| 17 | The action of selected isothiocyanates on bacterial biofilm prevention and control显示文摘 | Borges A Simes L C Saavedra M J | 2014 | International Biodeterioration & Biodegradation2014，86，： | 1 |
| 18 | The Role of Tool Geometry in Process Damped Milling显示文摘 | Yusoff A R Taylor C M Sims N D | 2010 | In ternational Journal of Advanced Manufacturing Technology2010，50，： | 1 |
| 19 | Electrostatic effects on first pass transfer efficiency in the application of powder coatings显示文摘 | Sims R A Mazumder M K Liu X | 2001 | IEEE Trans Ind Appl2001，，37： | 1 |
| 20 | Comparisonof testing solutions on the protection of Al-alloys using a Mg-richprimer 显示文摘 | Battocchi D Sim?es A M Tallman D E Bierwagen G P | 2006 | Corrosion Science2006，48，8： | 1 |
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