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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Phase formation in YAG powder synthesized by chemical methods 显示文摘 | SIM S M KELLER K A | 2000 | J Mater Sci2000，35，： | 2 |
| 3 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 4 | A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer 显示文摘 | Sim B K L O'Reilly M S Liang H | 1997 | Cancer Research1997，57，： | 2 |
| 5 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 6 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 7 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 8 | Chelate-assisted Phytoextraction of Lead from Contaminated Soils显示文摘 | Cooper E M Sims J T Cumningham S D | 1999 | Environ Qual1999，28，： | 1 |
| 9 | Anti-solvent co-crystallization of carbamazepine and saccharin显示文摘 | Wang I C Lee M J Sim S J | 2013 | Int J Pharm2013，450，： | 1 |
| 10 | A price-and-time-slot- negotiation mechanism for cloud service reservations显示文摘 | Son S Sim K M | 2012 | 1EEE Transactions on Systems Man and Cybernetics Part B:Cybernetics2012，42，3： | 1 |
| 11 | The CMU pose,illumination,and expression database显示文摘 | SIM T BAKER S BSAT M | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，12： | 1 |
| 12 | Training the neocognitron network using design of experiments显示文摘 | TEO M Y SIM S K | 1995 | Artificial Intelligence in Engineering1995，9，： | 1 |
| 13 | A review of model applications for structured soils:Water flow and tracer transport显示文摘 | KOHNE J M KOHNE S SIM/JNEK J | 2009 | Contaminant Hydrology2009，104，14： | 1 |
| 14 | M apping of serotypespecific,im m unodom inantepitopes in the NS-4region ofhepatitisC virus(H CV):use oftype-specific peptidesto serologically differentiate infections with H CV types1,2,and3显示文摘 | Sim m onds P Rose KA Graham S | 1993 | J Clin M icrobiol1993，31，6： | 1 |
| 15 | Dependence of osteoblastic response on variations in the chemical composition and physical properties of hydroxyapatite显示文摘 | BEST S SIM B KAYSER M | 1997 | J Mater Sci: Mater in Med1997，8，： | 1 |
| 16 | The CMU pose,illumination and expression dataset显示文摘 | Sim T Baker S Bsat M | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，12： | 1 |
| 17 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry显示文摘 | Feeley E M Sims J S John S P | 2011 | PLo S Pathogens2011，7，10： | 1 |
| 18 | The CMU pose, illumination, and expression database 显示文摘 | Sim T Baker S Bsat M | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，12： | 1 |
| 19 | A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer显示文摘 | SIM B K L O'REILLY M S LIANG H | 1998 | Cancer Res1998，57，： | 1 |
| 20 | High cell density culture of Anabaena variabilis using repeated injections of carbon dioxide for the production of hydrogen显示文摘 | YOON J H SIM S J KIM M S | 2002 | Int J Hydrogen Energy2002，27，11： | 1 |
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