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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 3 | Carrying capacity in the tourism industry: a case study of Hengistbury Head显示文摘 | Simon F J G Narangajavana Y Marquis D P | 2004 | Tourism Manage- ment2004，25，： | 1 |
| 4 | Reaction of o-phthalaldehyde and thiols with primary amines: formation of 1-alkyl(and aryl) thio-2-alkylisoindoles显示文摘 | Simons JR S Johnson D F | 1978 | J Org Chem1978，43，14： | 1 |
| 5 | Determination of organophlsphorus pesticide residues in Cilento( Campania, Italy)virgin olive oil by capillary gas chromatography 显示文摘 | I RASTRELLI L TOTARO K SIMONE F D | 2002 | Food Chemistry2002，79，： | 1 |
| 6 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 7 | Neurobehavioral function and tibial and chelatable lead levels in 543 former organo lead workers显示文摘 | STEWART W F SCHWARIZ B S SIMON D | 1999 | Neurology1999，52，： | 1 |
| 8 | Clinical evidence for a detrimen-tal effect on uterine receptive If high serum oestradiol concentrationsin high and normal responder patients 显示文摘 | Simon C Cano F Valbuena D | 1995 | Hum Reprod1995，，： | 1 |
| 9 | Open systems: panoramic views of gene expression 显示文摘 | Green C D Simons J F Taillon B E | 2001 | Journal of Immunological Methods2001，250，12： | 1 |
| 10 | Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia显示文摘 | Ferrara F D'Arco AM De Simone M | 2005 | Haematologica2005，90，6： | 1 |
| 11 | Error Analysis of Continuous GPS Position Time Series 显示文摘 | SIMON W D P YEHUDA B PENG F | 2004 | JGR2004，109，03： | 1 |
| 12 | Treatment with simva - statin in normocholesterolemic patients with Alzheimer' s disease : A 26 week randomized, placebo - controlled, double - blind trials 显示文摘 | Simons M Sehwarzler F Lutjohann D | 2002 | Ann Neurol2002，52，3： | 1 |
| 13 | The role of estrogen in uterine receptivity and blastocyst implantation 显示文摘 | Simon C Domingguez F Valbuena D | 2003 | Trends Endocrinol Metab2003，14，： | 1 |
| 14 | China' s Innovation Policies:Evolution,Institutional Structure,and Trajectory显示文摘 | Liu F C Simon D F Sun Y T | 2011 | Research Policy2011，40，7： | 1 |
| 15 | High -resolution Xist binding maps reveal two - step spreading during X - chromosome in- activation 显示文摘 | SIMON M D PINTER S F FANG R | 2013 | Nature2013，504，7480： | 1 |
| 16 | The role of estrogen in uterine receptivity and blastocyst implantation显示文摘 | Simon C Domingguez F Valbuena D | 2003 | Trends Endocrinol Metab2003，14，5： | 1 |
| 17 | Car- rying capacity in the tourism industry= A case study of Hengistbury Head显示文摘 | SIMON F G NARANGAJAVANA Y MARQUES D P | 2004 | Tourism Management2004，25，2： | 1 |
| 18 | A new method for the nonlinear transformation of means and covarianees in filters and estimators显示文摘 | SIMON J JEFFREY U HUGH F D W | 2000 | IEEE Trans- action on Automatic Control2000，45，3： | 1 |
| 19 | A QTL affecting milk yield and composition maps to bovine chromosome 20: A confirmation 显示文摘 | Arranz J J Coppieters W Berzi P Cambisano N Grisart B Karim L Marcq F Moreau L Mezer C Riquet J Simon P Vanmanshoven P Wagenaar D and Georges M | 1998 | Animal Genetics1998，29，： | 1 |
| 20 | Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans显示文摘 | Simon F Varela D Cabello-Verrugio C | 2013 | Cell Signal2013，25，7： | 1 |
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