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| 1 | p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemotherapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases(PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. Immunotherapy is now emerging as a promising treatment modality in the era of personalized anti-cancer therapeutics. In this review, basic knowledge of PAK structure and regulation is briefly summarised and the pivotal role of PAKs in Kras-driven pancreatic cancer is highlighted in terms of tumour biology and chemoresistance. Finally, the involvement of PAKs in immune modulation in the tumour microenvironment is discussed and the potential advantages of targeting PAKs are explored. | Kai Wang Graham S Baldwin Mehrdad Nikfarjam Hong He | 2018 | World Journal of Gastroenterology2018，24，33： | 7 |
| 2 | Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation显示文摘Liver ischaemic preconditioning (IPC) is known to protect the liver from the detrimental effects of ischaemic-reperfusion injury (IRI), which contributes significantly to the morbidity and mortality following major liver surgery. Recent studies have focused on the role of IPC in liver regeneration, the precise mechanism of which are not completely understood. This review discusses the current understanding of the mechanism of liver regeneration and the role of IPC in this setting. Relevant articles were reviewed from the published literature using the Medline database. The search was performed using | D Gomez S Homer-Vanniasinkam AM Graham KR Prasad | 2007 | World Journal of Gastroenterology2007，13，5： | 5 |
| 3 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 4 | 哮喘治疗的新进展显示文摘没有强有力的循证医学证据表明饮食方法或Buteyko技术对哮喘的临床管理有很大益处需要进一步研究确定当哮喘控制欠佳时患者应该怎么做小剂量吸入皮质激素可以和长效β2激动剂联合应用,以提供安全有效的哮喘控制静脉镁制剂和白三烯受体拮抗剂对急性哮喘可能具有一些作用,但仍需进一步评价将来哮喘治疗是否能得到炎症生物标志或患者基因型认识的帮助。 | Graeme P Currie Graham S Devereux Daniel K C Lee Jon G Ayres 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 5 | 饮食防癌研究进展显示文摘本文作者对最近进行的有关纤维素、脂肪、热量、维生素A、饮酒等膳食因素与多种部位癌症危险性关系的流行病学研究和动物实验结果作了较为全面的综述和评价。指出今后除需进一步阐明单一膳食因素的致癌作用外,还应加强膳食成分之间以及膳食与其它因素之间的相互作用对癌症危险性影响的研究。 | Freudenheim JL Graham S 余丽莉 | 1991 | 国外医学(卫生学分册)1991，18，2： | 3 |
| 6 | 冠状动脉钙化在高血压患者心血管病风险分层中的作用显示文摘研究者研究了冠状动脉钙化(coronary artery calcium,CAC)在成人高血压心血管病风险分层中的作用,包括符合收缩压干预试验(systolic blood pressure intervention trial,SPRINT)标准的患者。此外,研究者使用CAC来确定心血管病死亡率与SPRINT中标准降压组心血管病死亡率('SPRINT水平')相当的高血压成年患者,其可能受益于强化降压治疗。研究人群包括来自CAC研究联盟的高血压患者16 167例,其中6375例患者构成'SPRINT类似人群'。研究者按CAC分类(0,1~99,100~399,≥400)比较了多因素校正后的冠状动脉粥样硬化性心脏病(冠心病)和心血管病死亡风险比。 | 刘青(译) 叶鹏(摘、审校) Uddin SMI Mirbolouk M Kianoush S Orimoloye OA Dardari Z Whelton SP Miedema MD Nasir K Rumberger JA Shaw LJ Berman DS Budoff MJ McEvoy JW Matsushita K Blaha MJ Graham G | 2019 | 中华高血压杂志2019，27，5： | 3 |
| 7 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 8 | Optimising the preparation of activated carbon from digested sewage sludge and coconut husk显示文摘 | J.H Tay X.G Chen S Jeyaseelan N Graham | 2001 | Chemosphere2001，，1： | 2 |
| 9 | Ratio of microbial biomass carbon to soil organic carbon as a sensitive indicator of changes in soil organic matter显示文摘 | Graham P S | 1992 | Aust J Soil Res1992，30，： | 2 |
| 10 | Physical and chemical properties study of the activated carbon made from sewage sludge显示文摘 | Xiaoge Chen S Jeyaseelan N Graham | 2002 | Waste Management2002，，7： | 2 |
| 11 | Laboratory assessment of hepatic injury in the woodchuck (Marmota monax)显示文摘 | Hornbuckle W E Graham E S Roth L | 1985 | Lab Anim Sci1985，35，： | 1 |
| 12 | Conditional genotypic probabili ties for microsatellite loci显示文摘 | Curran J Weir B S | 2000 | Genetics2000，155，4： | 1 |
| 13 | Adjustment Approach for Fuzzy Logic Model Based Selection of Non-overlapping Machining Data in the Turning Operation显示文摘 | K Hashmi I D Graham B Mills M S J Hashmi | 2003 | Journal of Materials Processing Technology2003，142，： | 1 |
| 14 | Sedimentary record and climatic implications of recurrent deformation in the Tian Shan: Evidence from Mesozoic strata of the north Tarim,south Junggar,and Turpan basins, northwest China显示文摘 | Hendrix M S Graham S A Carroll A R | 1992 | Geological Society of America Bulletin1992，104，： | 1 |
| 15 | Acute severe asthma treated by mechanical ventilation: a comparison of the changing characteristics over a 17 yr period显示文摘 | Kearney S E Graham D R Atherton S T | 1998 | Respir Med1998，92，： | 1 |
| 16 | Late Oligocene-Early Miocene unroofing in the Chinese Tian Shan:An early effect of the India-Asia collision显示文摘 | Hendrix M S Dumitru T A Graham S A | 1994 | Geology1994，22，： | 1 |
| 17 | A prospective study for the association of Helicobacter polori infection to a multidimensional measure for recurrent abdominal pain in children 显示文摘 | Malaty HM Abudayyeh S Graham DY | 2006 | Helicobactor2006，11，4： | 1 |
| 18 | Purification and developmental analysis of a metalloendoproteinase from the leaves of Glycine max显示文摘 | GRAHAM J S XIONG J GILLIKIN J W | 1991 | Plant Physiology1991，97，2： | 1 |
| 19 | Biological challenges and technological opportunities forrespiratory syncytial virus vaccine development显示文摘 | GRAHAM B S | 2011 | Immunol Rev2011，239，1： | 1 |
| 20 | Detrital zir- con provenance of the Late Triassic Songpan Ganzi com- plex: Sedimentary record of collision of the North and South China blocks显示文摘 | Weislogel A L Graham S A Chang E Z | 2006 | Geology2006，34，2： | 1 |
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