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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 3 | A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer 显示文摘 | Sim B K L O'Reilly M S Liang H | 1997 | Cancer Research1997，57，： | 2 |
| 4 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 5 | 基于分布式传感网络的结构模态识别方法显示文摘结构的模态参数识别是结构健康监测系统的基本任务。随着工程结构的日益大型化和复杂化,振动测试时需要布置大量的传感器。传统的集中采集和处理技术将难以胜任海量数据的处理要求,采用无线智能传感器的结构健康监测系统正是应运而生的新方向,而分布式采集和处理是其特点。在无线智能传感网络拓扑结构中采用分布式算法求解结构整体振型,利用随机子空间法识别各子结构模态,结合粒子群优化算法调整子振型获取结构整体振型。通过混凝土钢管拱桥模型试验验证了分布式算法的可行性,并利用模态置信度(MAC)对比分析了由分布式模态识别方法和集中式模态识别方法得到的结果,结果表明两种算法吻合较好。 | 张敏 谢慧才 Sung han Sim B F Spencer Jr | 2010 | 土木工程学报2010，43，3： | 2 |
| 6 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 7 | Evaluation of fly ash as a soil amendment for the Atantic coastal plain:Ⅰ, soil hydraulic properties and elemental leaching显示文摘 | Ghodrati M Sims J T Vasilas B L | 1995 | Water Air and soil pollution1995，8，1： | 1 |
| 8 | Experimental behavior of a steel structure under natural fire 显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 9 | Taking the easy way out:Non-use and misuse of clues in EFL reading 显示文摘 | Laufer B & Sim D D | 1985 | English Teaching Forum1985，，232： | 1 |
| 10 | Angiostatin and endostatin:endothelial cellspecific endogenous inhibitors of angiogenesis and tumor growth显示文摘 | SIM B K | 1998 | Angiogenesis1998，2，1： | 1 |
| 11 | Phosphorus loss in agricultural drainage: Historical perspective and current research显示文摘 | Sims J T Simard R R Joern B C | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 12 | Nonmehing-flesh trait in peaches is not related to low ethylene production rates显示文摘 | Brovelli E A Brecht J K Sherman W B Sims C A | 1999 | HortScience1999，34，： | 1 |
| 13 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 14 | The Calculation of Roll Force and Torque in Hot Rolling Mills显示文摘 | Sims R B | 1954 | Proc Inst Mech Eng1954，168，6： | 1 |
| 15 | Blends of synthetic and natural polymers as drug delivery systems for growth hormone 显示文摘 | Downes B Sim S | 1995 | Biomaterials1995，16，7： | 1 |
| 16 | Nutrient management for intensive animal agriculture:policies and practices for sustainabl ity 显示文摘 | Sims J T BergstrOm Bowman B T | 2005 | Soil Use and Management2005，21，： | 1 |
| 17 | On the performance and resonant frequency of electromagnetic induction energy harvesters显示文摘 | MANN B P SIMS N D | 2010 | Journal of Sound and Vibration2010，329，9： | 1 |
| 18 | A parametric formulation of the generalized spectral subtraction method 显示文摘 | Sim B L Tong Y C Chang J S | 1998 | IEEE Trans on Speech and Audio Pro- cessing1998，6，4： | 1 |
| 19 | Influence of dietary energy source on performance and fatty liver syn- drome in White Leghorn laying hens显示文摘 | Bragg D B Sim J S Hodgson G C | 1973 | Poult Sci1973，52，2： | 1 |
| 20 | Not sodifferent after all:a crossdiscipline view of trust显示文摘 | Dennise M Rousseau Sim B Sitkin Colin Camerer | 1998 | Academy of Management Review1998，，3： | 1 |
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