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| 1 | Gallbladder motor function, plasma cholecystokinin and cholecystokinin receptor of gallbladder in cholesterol stone patients显示文摘AIM: To study the interactive relationship of gallbladder motor function, plasma cholecystokinin (CCK) and cholecystokinin A receptor (CCK-R) of gallbladder in patients with cholesterol stone disease.METHODS: Gallbladder motility was studied by ultrasonography in 33 patients with gallbladder stone and 10 health subjects as controls. Plasma CCK concentration was measured by radioimmunoassay in fasting status (CCK-f) and in 30 min after lipid test meal (CCK-30).Radioligand method was employed to analyze the amount and activity of CCK-R from 33 gallstone patients having cholecystectomy and 8 persons without gallstone died of severe trauma as controls.RESULTS: The percentage of cholesterol in the gallstone composition was more than 70%. The cholesterol stone type was indicated for the patients with gallbladder stone in this study. Based on the criterion of gallbladder residual fraction of the control group, 33 gallstone patients were divided into two subgroups, contractor group (14 cases)and non-contractor group (19 cases), The concentration of CCK-30 was significantly higher in non-contractor group than that in both contractor group and control group (55.86±3.86 pmol/l vs 37.85±0.88 pmol/l and 37.95±0.74 pmol/L, P<0.01), but there was no difference between contractor group and control group. Meanwhile no significant difference of the concentration of CCK-f could be observed among three groups. The amount of CCK-R was lower in non-contractor group than those in both control group and contractor group (10.27±0.94 fmol/mg vs24.59±2.39 fmol/mg and 22.66±0.55 fmol/mg, P<0.01).The activity of CCK-R shown as KD in non-contractor group decreased compared to that in control group and contractor group. Only was the activity of CCK-R lower in contractor group than that in control group. The ejection fraction correlated closely with the amount of CCK-R (r = 0.9683,P<0.01), and the concentration of CCK-30 correlated negatively with the amount of CCK-R closely (r = -0.9627,P<0.01).CONCLUSION: The distinctive interactive relationship of gallbladder emptying, plasma CCK and CCK-R in gallbladder from this study suggested that the defect of CCK-R may be a key point leading to the impairment of gallbladder motor function and the pathogenesis of cholesterol gallstoneformation may differ in two subgroups of gallstone patient,gallbladder non-contractor group or contractor group. | JianZhu Tian-QuanHan ShengChen YuJiang Sheng-DaoZhang | 2005 | World Journal of Gastroenterology2005，11，11： | 46 |
| 2 | Polymorphisms at cholesterol 7α-hydroxylase,apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease显示文摘AIM: To investigate the relationship between gallbladder stone disease (GSD) and single nucleotide polymorphisms of cholesterol 7α-hydroxylase (CYP7A) gene promoter,apolipoprotein (APO) B gene exon 26, APOEgene exon 4 or microsatellite polymorphism of low density lipoprotein receptor (LDLR) gene exon 18.METHODS: Genotypes of CYP7A, APOB, APOE and LDLR genes were determined in 105 patients with GSD diagnosed by B-mode ultrasonography and 274 control subjects.Serum lipids were analyzed with HITACHI 7060 automaic biochemical analyzer.RESULTS: Body mass index (BMI) was significantly higher in patients with GSD (24.47±3.09) than in controls (23.50±2.16).Plasma total cholesterol was lower in patients with GSD (4.66±0.92 mmol/L) than in controls (4.91±0.96 mmol/L),P<0.01 after adjusted for age, sex and BMI. The significantly higher frequency of A allele of CYP7A gene polymorphism and X+ allele of APOBgene polymorphism was seen in GSD patients. Percentages of A allele in patients and controls were 62.86% and 54.38% (P <0.05) and those of X+ allele 8.57% and 4.01% (P<0.01). Subjects with A allele had significantly lower plasma total cholesterol and LDL cholesterol than subjects with CC homozygote. In a multiple variable logistic regression model, the BMI (OR=1.13, 95% CI: 1.05-1.22), A allele (OR=1.48, 95% CI: 1.05-2.09) and X+ allele (OR=2.28, 95% CI: 1.14-4.59) were positively associated with GSD (P <0.05). Plasma total cholesterol (OR=0.69, 95% CI: 0.64-0.74) was negatively related to GSD (P<0.05).CONCLUSION: With an association analysis, it was determined that A allele of CYP7A gene and X+ allele of APOB gene might be considered as risk genes for GSD. These alleles are related with differences of serum lipids among subjects.Multiple-variable logistic regression model analysis showed that besides BMI, GSD was affected by polygenetic factors.But the mechanism for these two alleles responsible for GSD requires further investigations. | Zhao-YanJiang Tian-QuanHan Guang-JunSuo Dian-XuFeng ShengChen Xing-XingCai Zhi-HongJiang JunShang YiZhang YuJiang Sheng-DaoZhang | 2004 | World Journal of Gastroenterology2004，10，10： | 16 |
| 3 | In vitro Study on Role of Hsp70 Expression in DNA Damage of Human Embryonic Lung Cells Exposed to Benzo[a]pyrene显示文摘Objective Benzo[a]pyrene (B[a]P), a ubiquitous environmental pollutant, is a potent procarcinogen and mutagen that can elicit tumors, leading to malignancy. Heat shock proteins (Hsp) have been shown to protect cells against damages caused by various stresses including exposure to numerous chemicals. Whether Hsps, or more specifically Hsp70, are involved in repair of B[a]P-induced DNA damage is currently unknown. Methods We assessed the potential role of the inducible form of Hsp70 in B[a]P-induced DNA damage of human embryonic lung (HEL) cells using immunoblot and the comet assay (i.e., the single cell gel electrophoresis assay). Results Exposure to B[a]P induced a dose-dependent decrease in the level of Hsp70, but a dose-dependent increase in DNA damage both in untreated (control) HEL cells and in cells preconditioned by a heat treatment. Heat preconditioning prior to B[a]P exposure potentiated the effect of B[a]P at a low dose (10 (mol/L), but appeared to be protective at higher doses. There was a negative correlation between Hsp70 level and DNA damage in the non-preheated as well as in the preconditioned cells. Conclusion These data suggest that exposure of HEL cells to B[a]P may induce a dose-dependent reduction in the levels of the inducible Hsp70. The detailed mechanisms for the reduction of Hsp70 levels by B[a]P and the role of Hsp70 in DNA damage under different concentrations of B[a]P remains to be determined. | YA-JUANGAO CHENG-FENGXIAO SHENGCHEN RUI-BOWANG HAN-ZHENHE ROBERTMTANGUAY TANG-CHUNWU | 2004 | Biomedical and Environmental Sciences2004，17，2： | 8 |
| 4 | Particle behavior in homogeneous isotropic turbulence显示文摘Direct numerical simulations were conducted to investigate the behavior of heavy particles in homogeneous isotropic turbulence. The present study focused on the effect of particle inertia and drift on the autocorrelations of the particle velocity and the fluid seen by particles and the dispersion characteristics of particles. The Lagrangian integral time scale of particles monotonically increased as the magnitude of the particle response time increased, while that of the fluid seen by particles remained relatively constant; it reached a maximum when the particle response time was close to the Kolmolgorov time scale of the flow. Particle dispersion increased as the particle inertia increased for small particles, while for larger particles, it decreased as particle inertia increased; particle eddy diffusion coefficient was maximal, and greater than that of the fluid by about 30%, at the preferential concentration. The concentration field of the particles with τp/τk ≈ 1.0 showed that particles tend to collect in regions of low vorticity (high strain) due to preferential concentration. As the drift velocity of a particle is increasedit crosses the paths of fluid elements more rapidly and will tend to lose correlation with its previous velocity faster than a fluid element will. And the correlation of particle velocities along the drift direction is more persistent than that perpendicular to the direction of drift. Simulations also showed that the continuity effect and the crossing-trajectory effect are weakened for particles with infinite inertia. | ZhuHe ZhaohuiLiu ShengChen LeiWeng ChuguangZheng | 2005 | Acta Mechanica Sinica2005，21，2： | 7 |
| 5 | A Survey of Embedding Algorithm for Virtual Network Embedding显示文摘Network virtualization(NV) is pushed forward by its proponents as a crucial attribute of next generation network, aiming at overcoming the gradual ossification of current networks, particularly to the worldwide Internet. Through virtualization, multiple customized virtual networks(VNs), requested by users, are allowed to coexist on the underlying substrate networks(SNs). In addition, the virtualization scheme contributes to sharing underlying physical resources simultaneously and seamlessly. However, multiple technical issues still stand in the way of NV successful implementation. One key technical issue is virtual network embedding(VNE), known as the resource allocation problem for NV. This paper conducts a survey of embedding algorithms for VNE problem. At first, the NV business model for VNE problem is presented. Then, the latest VNE problem description is presented. Main performance metrics for evaluating embedding algorithms are also involved. Afterwards, existing VNE algorithms are detailed, according to the novel proposed category approach. Next, key future research aspects of embedding algorithms are listed out. Finally, the paper is briefly concluded. | Haotong Cao Shengchen Wu Yue Hu Yun Liu Longxiang Yang | 2019 | China Communications2019，16，12： | 5 |
| 6 | Node Ranking Strategy in Virtual Network Embedding: An Overview显示文摘Network virtualization(NV)is a highprofile way to solve the ossification problem of the nowadays Internet,and be able to support the diversified network naturally.In NV,Virtual Network Embedding(VNE)problem has been widely considered as a crucial issue,which is aimed to embed Virtual Networks(VNs)onto the shared substrate networks(SNs)efficiently.Recently,some VNE approaches have developed Node Ranking strategies to drive and enhance the embedding efficiency.Node Ranking Strategy rank/sort the nodes according to the attributes of the node,including both residual local attributes(CPU,Bandwidth,storage,Etc.)and the global topology attributes(Number of neighborhood Nodes,Delay to other nodes,Etc.).This paper presents an overview of Node Ranking Strategies in Virtual Network Embedding,and possible directions of VNE Node Ranking Strategy. | Shengchen Wu Hao Yin Haotong Cao Longxiang Yang Hongbo Zhu | 2021 | China Communications2021，18，6： | 3 |
| 7 | Revealing a steroid receptor ligand as a unique PPARγ 3gonist显示文摘 | Shengchen Lin Ying Han Yuzhe Shi Hui Rong Songyang Zheng Shikan Jin Shu-Yong Lin Sheng-Cai Lin Yong Li | 2012 | Cell Research2012，22，4： | 2 |
| 8 | Antioxidant activities and chemical profiles of pyroligneous acids from walnut shell显示文摘 | Qin Wei Xihan Ma Zhong Zhao Shanshan Zhang Shengchen Liu | 2010 | Journal of Analytical and Applied Pyrolysis2010，，2： | 2 |
| 9 | Does Monetary Policy Have Asymmetric Effects on Stock Returns?显示文摘 | SHIU‐SHENGCHEN | 2007 | Journal of Money Credit and Banking (鈥?)2007，，2： | 2 |
| 10 | In- volvement of Peripheral Beta-endorphin and Mu, Delta, Kappa opioid Receptors in Electroacupuncture Analgesia for Prolonged Inflammatory Pain of Rats显示文摘 | Fang jianqiao Jiang yongliang Qiu shengchen | 2013 | European Jour- nal of Inflammation2013，11，2： | 1 |
| 11 | Blow-up for a semilinear reaction-diffusion system coupled in both equations and boundary conditions显示文摘 | Shengchen FU J.S.GUO | | 0，，01： | 1 |
| 12 | Irreversible Sediment Formation in Green Tea Infusions显示文摘 | Yong‐QuanXu Gen‐ShengChen Qiu‐ShuangWang Hai‐BoYuan Chun‐HongFeng Jun‐FengYin | 2012 | Journal of Food Science2012，，3： | 1 |
| 13 | Preparation of Ultra‐Fine Nickel Manganite Powders and Ceramics by a Solid‐State Coordination Reaction显示文摘 | Dao‐laiFang Zhong‐bingWang Ping‐huaYang WeiLiu Chu‐shengChen A. J. A.Winnubst | 2005 | Journal of the American Ceramic Society2005，，1： | 1 |
| 14 | Characterization of multiple-antimicrobial resistant Escherichia coli isolates from diseased chickens and swine in China显示文摘 | Hanchun Yang ShengChen DavidG | 2004 | Journal of clini cal microbiology2004，42，8： | 1 |
| 15 | Metal rapid prototype fabrication using selective laser cladding technology 显示文摘 | JENG Jengywan PENG Shengchen CHOU Changjiu | 2000 | Advanced Manufacturing Technology2000，16，6： | 1 |
| 16 | Blue Photoluminescence from Chemically Derived Graphene Oxide显示文摘 | GokiEda Yun‐YueLin CeciliaMattevi HisatoYamaguchi Hsin‐AnChen I‐ShengChen Chun‐WeiChen ManishChhowalla | 2010 | Adv Mater2010，，4： | 1 |
| 17 | Predicting US‐ and state‐level cancer counts for the current calendar year显示文摘 | Huann‐ShengChen KennethPortier KaushikGhosh DeepaNaishadham Hyune‐JuKim LiZhu Linda W.Pickle MartinKrapcho SteveScoppa AhmedinJemal Eric J.Feuer | 2012 | Cancer2012，，4： | 1 |
| 18 | Products of commutators of dilatations显示文摘 | HONGYOU SHENGCHEN | 1999 | Linear algebra and its applications1999，291，： | 1 |
| 19 | Revealing the correlation between structural evolution and long-term cyclability of the LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)/artificial graphite pouch cells at various rates显示文摘In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely reported.However,limited attentions have been paid to understand the effects and influence mechanisms of charge and discharge rates and charge limit currents on cyclability of NCM523/AG cells.Herein,a∼1.9 Ah NCM523/AG pouch cell is employed,whose electrochemical and structural evolutions after 800 cycles at various rates are comprehensively investigated.We find that cycling performances are strongly influenced by charge rate,followed by limit current and discharge rate.The cell charged at a high rate and cell charged until reaching a low limit current both exhibit low capacity retentions compared to the cell discharged at a high rate.Possible failure reasons are analyzed by advanced characterizations.Results reveal that NCM523 cathodes of the cells deteriorated early experience severe transition metal dissolution,lattice distortion,and partial phase transformation.Meanwhile,the deposited transition metals on AG anodes catalyze the electrolyte consumption,lithium plating and active area loss.Finally,these side reactions notably increase cell impedance and electrochemical polarization.Undoubtedly,these findings clearly outline the challenges and optimization direction for high-rate NCM523/AG cells. | Xu-Feng Zang Shengchen Yang Ying Zou Yingying Zhang Tao Huang Hui-Ling Xia | 2023 | Particuology2023，，10： | 0 |
| 20 | Effect of C/N Ratio,Temperature,pH on Autotrophic Denitrification Rate with Hydrogen Gas,Iron(Ⅱ) and Sodium Sulfide as Electron Donors显示文摘Nitrate is considered to be one of the most widely present pollutants leading to eutrophication of environment. The purpose of this work was to isolate and identify new anaerobic denitrifying bacteria from reservoir sediments and utilize different electron donors for isolates to improve nitrate removal efficiency. Using traditional enrichment approach,one purified anaerobic bacterium( Y12) capable of NO-3-N removal from sediments was obtained. The species identity of Y12 was determined via 16 S rRNA gene sequence analysis to be Acinetobacter. In this work,the fastest denitrification rates were observed with ferrous iron as electron donor.And,slightly slower rates were observed with hydrogen and sodium sulfide as electron donors. However,when used hydrogen gas, ferrous iron and sodium sulfide as electron donors, C / N ratios had little effect on autotrophic denitrification rate at the initial C / N ratio from 1.5 to 9.0. Meanwhile,when made use of hydrogen gas,ferrous iron and sodium sulfide as electron donors,a maximum nitrate removal ratio of 100.00%,91.43%and 87.99% at the temperature of 30 ℃,respectively. Moreover,maximum denitrification activity was observed at p H 6.0-7.0. | Junfeng Su Sicheng Shao Tinglin Huang Fang Ma Gang Wen Shengchen Zheng Kai Zhang | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，1： | 0 |
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