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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Abdominal incision: decision or indecision? 显示文摘 | Cahalane M J Shapiro ME Silen W | 1989 | Lancet1989，8630，1： | 1 |
| 3 | Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in nonobese diabetic mice 显示文摘 | Shapiro A M Suarez-Pinzon W L Power R | 2002 | Diabetologia2002，45，2： | 1 |
| 4 | The effect of section of the medial collateral ligament on force generated in the anterior cruciate ligament 显示文摘 | Shapiro M S Markolf K L Finerman G A M Mitchell P W | 1991 | Journal of Bone and Joint Surgery1991，72，： | 1 |
| 5 | Self-healing in modern operating systems显示文摘 | SHAPIRO M W | 2004 | ACM Queue2004，2，9： | 1 |
| 6 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 7 | Acute acalculous cholecystitis in the critically ill显示文摘 | SHAPIRO M J LUCHTEFELD W B KURZWEIL S | 1994 | Am Surg1994，60，5： | 1 |
| 8 | lmmunohistochemical localization of calcium-binding proteins in the brainstem vestibular nucleiof the jaundiced Gunn rat显示文摘 | Shaia W T Shapiro S M Heller A J | 2002 | Hear Res2002，173，12： | 1 |
| 9 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 10 | Role of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model显示文摘 | MCDONALD J W SHAPIRO S M SILVERSTEIN F S | 1998 | Exp Neurol1998，150，1： | 1 |
| 11 | On the multi- variate asymptotic distribution of sequential chi-square statistics显示文摘 | Steiger J H Shapiro A Browne M W | 1985 | Psychometrika1985，50，3： | 1 |
| 12 | Alopecia areata:pathogenesis and potential for therapy显示文摘 | Lu W Shapiro J Yu M | 2006 | Expert Rev Mol Med2006，8，14： | 1 |
| 13 | Damage control:col- lective review显示文摘 | Shapiro M B Jenkins D H Schwab C W | 2000 | J Trauma2000，49，5： | 1 |
| 14 | The employee - organization relationship: a timely concept in a period of transition 显示文摘 | Shore L M Tetrick L E Taylor M S Coyle - Shapiro J A - M Liden R C McLean - Parks J Morrison E W Porter L W Robinson S L Roehling M V Rousseau D M Schalk R Tsui A S Van Dyne L | 2004 | Research in Personnel and Human Resources Management2004，，23： | 1 |
| 15 | Top-up Search and the Attentional Blink:A Two-Stage Account of the Preview Effect in Search显示文摘 | Kunar M A Shapiro K L Humphreys G W | 2006 | Visual Cognition2006，13，6： | 1 |
| 16 | Solid viscus injury predicts major hollow viscus injury in blunr abdominal trauma显示文摘 | Nace M L Pedon G W Shapiro M B | 1997 | J Trauma1997，43，4： | 1 |
| 17 | Super-resolution imaging in livecaulobacter crescentus cells using photoswitchable EYFP显示文摘 | Biteen J S Thompson M A Tselentis N K Bowman G R Shapiro L Moerner W | 2008 | Nature Methods ?2008，5，94： | 1 |
| 18 | Trichome-borne and artificially applied acylsugars of wild tomato deter feeding and oviposition of the leafminer, Liriomyza trifolii显示文摘 | Hawthorne D M Shapiro J A Tingey W M Mutschler M A | 1992 | Entomol Exp Appl1992，65，： | 1 |
| 19 | A brief review of practical pre- operative cognitive screening tools显示文摘 | Long L S Shapiro W A Leung J M | 2012 | Can J Anaesth2012，59，8： | 1 |
| 20 | Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice显示文摘 | RABINOVITCH A SUAREZ PINZON W L SHAPIRO A M | 2002 | Diabetes2002，51，3： | 1 |
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