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| 1 | 依前列醇长期治疗原发性肺动脉高压的临床资料分析显示文摘目的 观察依前列醇长期治疗原发性肺动脉高压 (PPH)的疗效。方法 临床诊断为PPH且心功能为Ⅲ~Ⅳ级的慢性充血性心力衰竭患者 69例 ,均接受依前列醇长期静脉连续注入治疗(起始剂量在 2~ 62ng·kg- 1 ·min- 1 范围内。在长期治疗中 ,药物剂量应根据患者的反应进行调整 ,剂量通常随治疗时间每 2个月增加 1次 ,每次增加 1~ 2ng·kg- 1 ·min- 1 )并观察其疗效。用右心导管法和超声心动图检查法对所有患者测量三尖瓣跨瓣压 (ΔP)和心输出量 (CO)。随访期间每 4个月用超声心动图检查法复查上述指标 1次。结果 PPH患者长期用依前列醇治疗后 ,ΔP由 (84 1± 2 4 1 )mmHg (1mmHg=0 1 33kPa)降至 (62 7± 1 8 2 )mmHg(P <0 0 1 ) ,CO由 (4 0 0± 1 2 2 )L/min升至 (4 70± 1 2 7)L/min(P <0 0 2 ) ,ΔP/CO由 2 2 8± 9 4降至 1 4 9± 6 5(P <0 0 1 )。结论 长期静脉连续注入依前列醇治疗PPH ,可使患者右室压力逐渐下降 ,CO增加 。 | 曹铁生 袁丽君 段云友 王作军 庄磊 Shelley M Shapiro Bruce H Brundage | 2003 | 中华内科杂志2003，42，2： | 16 |
| 2 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 3 | 糖尿病患者服用β受体阻滞剂的心血管事件风险显示文摘β受体阻滞剂可能有助于获得强化血糖控制的最大效果,但也存在发生严重低血糖的潜在风险。该研究旨在评估糖尿病患者服用β受体阻滞剂是否有效及其应用是否与严重低血糖有关。 | Tsujimoto T Sugiyama T Shapiro MF Noda M Kajio H 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，6： | 6 |
| 4 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 5 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 6 | Hoist scheduling for a PCB electroplating facility显示文摘 | SHAPIRO G W NUTTLE H W | 1988 | HE Transactions1988，20，2： | 1 |
| 7 | Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality显示文摘 | Kilgannon J H Jones A E Shapiro N I | 2010 | JAMA2010，303，： | 1 |
| 8 | Universal vectors for operators on spaces of holomorphic functions显示文摘 | Gethner R M Shapiro J H | 1987 | Proc Amer Math Soc1987，100，2： | 1 |
| 9 | The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle显示文摘 | Lepor H Tang R Shapiro E | 1993 | Prostate1993，22，4： | 1 |
| 10 | Cross cascade activation of ERKs and ternary complex factors by Rho family proteins显示文摘 | Frost JA Steen H Shapiro P | 1997 | EMBO J1997，16，64： | 1 |
| 11 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 12 | Hoist scheduling for a PCB electroplating facility显示文摘 | Nuttle H W | 1988 | IIE Transactions1988，20，2： | 1 |
| 13 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | Shapiro MD Homg H | 2003 | Mayo clinproe2003，78，6： | 1 |
| 14 | Non-line-of -sight singlescatter propagation model显示文摘 | Mark R Luettgen Jeffrey H Shapiro | 1991 | J Optical Society of America1991，8，： | 1 |
| 15 | Anti-inflammatory prop- erties of omega-3 fatty acids in critical illness: novel mecha- nisms and an integrative perspective 显示文摘 | Singer P Shapiro H Theilla M | 2008 | Intensive Care Med2008，34，9： | 1 |
| 16 | Nuclvotide sequence and estrogen induction of Xenopus laevis 3-hydroxy-3-methylglutaryl coenzyme A reductase显示文摘 | Hen H Shapiro D J | 1990 | J Biol Chem1990，265，： | 1 |
| 17 | The influence of the ion-atom potential on molecular dynamics simulations of sputtering 显示文摘 | Shapiro M H Ping Lu | 2004 | Nuclear Instruments and Methods in Physics Research B2004，215，： | 1 |
| 18 | Consumer Attitudes,Buying Intentions and Expenditures:an Analysis of the Canadian Data显示文摘 | Shapiro H Angevine G | | 0，，02： | 1 |
| 19 | Depression and the course of coronary artery disease 显示文摘 | GLASSMAN A H SHAPIRO P A | 1998 | Am J Psychiatry1998，155，1： | 1 |
| 20 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
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