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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 3 | 女性使用生物燃料相关的慢性阻塞性肺疾病:一项系统性回顾和meta分析显示文摘目的慢性阻塞性肺疾病(COPD)是世界范围内患病率和死亡率不断增长的主要疾病。女性的COPD患病率较男性增长更快,因为女性更常暴露在生物燃料燃烧产生的室内污染物中。 | 王臻(译) 施焕中(校) Adama Sana Serge M A Somda Nicolas Meda Catherine Bouland | 2018 | 英国医学杂志中文版2018，21，6： | 5 |
| 4 | Pharmacology and chemistry of adapalene 显示文摘 | Braham S Serge M Sophia A | 1997 | J Am Acad Dermatol1997，36，： | 2 |
| 5 | Carbon fibers and composites with epoxy resins: Topography, fractography and interphases显示文摘 | Shang-Lin Gao Edith M?der Serge F. Zhandarov | 2004 | Carbon2004，，3： | 2 |
| 6 | Why Is the Climate Forcing of Sulfate Aerosols So Uncertain?显示文摘Sulfate aerosol particles have strong scattering effect on the solar radiation transfer which results in in- creasing the planet albedo and, hence, tend to cool the earth-atmosphere system, Also, aerosols can act as the cloud condensation nuclei (CCN) which tend to increase the albedo of clouds and cool the global warm- ing. The ARPEGE-Climat version 3 AGCM with FMR radiation scheme is used to estimate the direct and indirect radiative forcing of sulfate aerosols. For minimizing the uncertainties in assessing this kind of cool- ing effect, all kinds of factors are analyzed which have been mixed in the assessment process and may lead to the different results of the radiative forcing of aerosols, It is noticed that one of the uncertainties to assess the climate forcing of aerosols by GCM results from the different definition of radiative forcing that was used. In order to clarify this vague idea, the off-line case for considering no feedbacks and on-line case for including all the feedbacks have been used for assessment. The direct forcing of sulfate aerosols in off-line case is -0.57 W/ m2 and -0.38 W / m2 for the clear sky and all sky respectively. The value of on-line case appears to be a little larger than that in off-line case chiefly due to the feedback of clouds. The indirect forc- ing of sulfate aerosols in off line case is -1 .4 W / m2 and -1 .0 W / m2 in on-line case. The radiative forcing of sulfate aerosols has obvious regional characteristics. There is a larger negative radiative forcing over North America, Europe and East Asia. If the direct and indirect forcing are added together, it is enough to offset the positive radiative forcing induced by the greenhouse gases in these regions. | Hu Rongming, Serge Planton, Michel Deque, Pascal Marquet and Alain Braun Centre national de recherches m t orologiques, Meteo-France | 2001 | Advances in Atmospheric Sciences2001，18，6： | 2 |
| 7 | Nebivolol and metoprolol: long- term effects on inflammation and oxidative stress in es- sentialhypertension显示文摘 | Serg M Kampus P Kals J | 2012 | Scand J Clin Lab Invest2012，72，5： | 1 |
| 8 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness 显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 9 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 10 | PhoP:A Missing Piece in the Intricate Puzzle of Mycohactefium tuberculosis Virulence 显示文摘 | Jesu's GA Serge M Jose HW | 2008 | PIoS ONE2008，3，10： | 1 |
| 11 | Analysis of underactuated mechanicalgrippers显示文摘 | Serge Montambault Clement M Gosselin | 2001 | Journal of Mechanical Design2001，123，： | 1 |
| 12 | Development of an IL-6 inhibitor based on the functional analysis of routine IL-6 Ra显示文摘 | Miesinger M Y Serge H Stefan W | 2009 | Chem and Biol2009，16，7： | 1 |
| 13 | Cytochrome c oxidase defects of the human substantia nigra in normal aging显示文摘 | KYOKO I SERGE W PARVIZ M | 1996 | Neurobiol Aging1996，17，： | 1 |
| 14 | HRP/ redox clay-based biosensor: Design and optimization for cyanide detection显示文摘 | Dan 8 Serge C Christine M | 2004 | BiosensorsandBioelectronics2004，20，39： | 1 |
| 15 | What does the fulture hold for BNP in cardiology? 显示文摘 | Robertol L Aldo PM Serge M | 2001 | Heart2001，86，： | 1 |
| 16 | Association of osteoprote- gerin with aortic stiffness in patients with symptomatic periph- eral artery disease and in healthy subjects显示文摘 | Zagura M Serg M Kampus P | 2010 | Am J Hypertens2010，23，6： | 1 |
| 17 | Green's function construction for 2D and 3D elastic random media显示文摘 | Tobias M M Serge A S | 1999 | Expanded Abstracts of 69^th Annual Internal SEG Mtg1999，，： | 1 |
| 18 | The origin and nature of flame retardance in ethylene - vinyl acetate copolymers containing hostaflam AP 750 显示文摘 | Bugajny M Serge Bourbigot S Le Bras M | 1999 | Polymer International1999，48，4： | 1 |
| 19 | Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantation 显示文摘 | LUC M SERGE L | 2006 | Liver Transplantation2006，12，1： | 1 |
| 20 | Differential effects of nebivolo! and metoprolol on central aortic pressure and left ventricular wall thickness显示文摘 | Kampus P Serg M Kals J ecal | 2011 | Hypertension2011，57，6： | 1 |
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