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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study显示文摘 | LUC G BARD J M ARVEILER D | 2001 | Atherosclerosis2001，163，2： | 2 |
| 4 | The relevance of size efficiency to biomanipulation theory:a field test under hypertrophic conditions显示文摘 | Steven D Luc D M Nicole P | 1997 | Hydrobiologia1997，360，： | 2 |
| 5 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 6 | Biological treatment process of air loaded with an ammonia and hydrogen sulfide mixture显示文摘 | Luc M | 2003 | Chemosphere2003，，50： | 1 |
| 7 | Plasma cystatipment of cornary heart disease:The PRIME Study显示文摘 | Luc G Bard J M Lesuer C | | 0，，2： | 1 |
| 8 | Plant parasitic nematodes in sub-tropical and tropical agriculture 显示文摘 | Luc M Sikora R A Bridge J | 1990 | CAB International1990，，： | 1 |
| 9 | Absorption of a mixture of volatile organic compounds(VOCs) in aqueous solutions of soluble cutting oil显示文摘 | FRANK L LUC M JEAN-CLAUDE R | 2008 | Bioresource Technology2008，99，6： | 1 |
| 10 | Plant parasitic nematodes in subtropical and tropical agriculture显示文摘 | Luc M Sikoro R A Bridge J | 1990 | UK: CAB International1990，，： | 1 |
| 11 | C-reactive protein, interleukin-6 and fibrinogen as predictors of coronary heart disease:the PRIME study 显示文摘 | Luc G Bard J M Juhan-Vague I | 2003 | Arterioscler Thromb Vasc Biol2003，23，7： | 1 |
| 12 | Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D显示文摘 | Tomasello E Luc as M | 2002 | Nat Immunol2002，3，12： | 1 |
| 13 | Angiotensin I - converting enzyme inhibitory peptides from tryptic hydrolysate of bovine a S2 - casein显示文摘 | Jerome T Iaurent M Jean- Luc G | 2002 | FEBSLett2002，531，： | 1 |
| 14 | Chronic hypothyroidism induces abnormal structure of high-density lipoproteins and impaired kinetics of apolipoprotein A-L in the rat显示文摘 | Huesca-gomez C Franco M Luc G | 2002 | Metabolism2002，51，4： | 1 |
| 15 | Impacts of recreational trampling on sub alpine vegetation and soils in Northwest Yun nan, China显示文摘 | Yang M Y Luc Hens Ou X K etal | 2009 | Acta Ecologica Sinica2009，29，3： | 1 |
| 16 | Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantation 显示文摘 | LUC M SERGE L | 2006 | Liver Transplantation2006，12，1： | 1 |
| 17 | C-reactive protein,interleukin-6,and fibrinogen as predictors of coronary heart disease:the PRIME Study显示文摘 | Luc G Bard J M Juhan-Vague I | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 18 | Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study 显示文摘 | LUC G BARD J M ARVEILER D | 2002 | Atherosclerosis2002，163，2： | 1 |
| 19 | How to treat arterial stiffness beyond blood pressure lowering?显示文摘 | Luc M Van Bortel Tine De Backer Marc De Buyzere | 2011 | Journal of Hypertension2011，，6： | 1 |
| 20 | Biofiltration of a mixture of volatile organic emissions显示文摘 | Aitor A Luc M Jean C R | 2001 | Air Waste Manag Assoc2001，51，12： | 1 |
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