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| 1 | Carbon Nanotubes in Biology and Medicine:In vitro and in vivo Detection,Imaging and Drug Delivery显示文摘Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years.In this comprehensive review,we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological systems.Ultrasensitive detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube surface.Electrical nanosensors based on nanotubes provide a label-free approach to biological detection.Surface-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/L.In vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible,nontoxic,and potentially useful for biomedical applications.In vivo biodistributions vary with the functionalization and possibly also size of nanotubes,with a tendency to accumulate in the reticuloendothelial system(RES),including the liver and spleen,after intravenous administration.If well functionalized,nanotubes may be excreted mainly through the biliary pathway in feces.Carbon nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA(siRNA),paclitaxel and doxorubicin.Moreover,single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence,Raman,and photoacoustic contrast agents for imaging of cells and animals.Further multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine. | Zhuang Liu Scott Tabakman Kevin Welsher Hongjie Dai | 2009 | Nano Research2009，2，2： | 50 |
| 2 | High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes显示文摘Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to date.Ex vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial resolution.Complete tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months post-treatment.Further,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in vivo.Highly effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for AuNRs.These results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy. | Joshua T.Robinson Kevin Welsher Scott M.Tabakman Sarah P.Sherlock Hailiang Wang Richard Luong Hongjie Dai | 2010 | Nano Research2010，3，11： | 20 |
| 3 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 4 | Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion显示文摘Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. | Qing-zhang Tuo Yu Liu Zheng Xiang Hong-Fa Yan Ting Zou Yang Shu Xu-long Ding Jin-jun Zou Shuo Xu Fei Tang Yan-qiu Gong Xiao-lan Li Yu-jie Guo Zhao-yue Zheng Ai-ping Deng Zhang-zhong Yang Wen-jing Li Shu-ting Zhang Scott Ayton Ashley I.Bush Heng Xu Lunzhi Dai Biao Dong Peng Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 5 | Cardiovascular physiology in the older adults显示文摘 | Xuming Dai Scott L Hummel Jorge B Salazar George E Taffet Susan Zieman Janice B Schwartz | 2015 | Journal of Geriatric Cardiology2015，12，3： | 2 |
| 6 | Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence显示文摘 | Bo Zhang Jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai | 2013 | Nano Research2013，6，2： | 2 |
| 7 | Product platform design through sensitivity analysis and cluster analysis 显示文摘 | Dai Z H Scott M J | 2007 | Journal of Intelligent Manufacturing2007，18，1： | 1 |
| 8 | Meaningful tradeoffs in Product family design considering monetary and technical aspects of commonality 显示文摘 | Dai Z Scott M J | 2005 | SAE International2005，114，6： | 1 |
| 9 | Effective Product family design using Preference aggregation 显示文摘 | Dai Z Scott M | 2006 | Journal of Mechanical Design2006，128，4： | 1 |
| 10 | Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas显示文摘 | Robb E. Wilentz Gloria H. Su Jia Le Dai Andrew B. Sparks Pedram Argani Taylor A. Sohn Charles J. Yeo Scott E. Kern Ralph H. Hruban | 2000 | The American Journal of Pathology2000，，1： | 1 |
| 11 | Development of the baseline model for a steel girder bridge using remote sensing and load tests 显示文摘 | Dai K Chen S Scott J | 2011 | Proceedings of the SPIE2011，，： | 1 |
| 12 | Product platform design through sensitivity analysis and cluster analysis显示文摘 | DAI Z H SCOTT M J | 2007 | Journal of Intelligent Manufacturing2007，18，： | 1 |
| 13 | Free partial latissimus dorsi myocutaneous flap for coverage of severe achilles contracture in children显示文摘 | L. Zhu J. Wei Sanjay Daluvoy Scott T. Hollenbeck Dai Chuan H. Xu J. Dong | 2012 | Journal of Plastic Reconstructive & Aesthetic Surgery2012，，： | 1 |
| 14 | Product platform design through sensitivity analysis and cluster analysis 显示文摘 | DAI Z SCOTT M J | 2007 | Journal of Intelligent Manufacturing2007，18，1： | 1 |
| 15 | Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice显示文摘 | Mei Junjie Liu Yuhong Dai Ning Hoffmann Christian Hudock Kristin M Zhang Peggy Guttentag Susan H Kolls Jay K Oliver Paula M Bushman Frederic D Worthen G Scott | 2012 | EN2012，，3： | 1 |
| 16 | Product platform design through sensitivity analysis and cluster analysis显示文摘 | DAI Z SCOTT M | 2007 | Journal of Intelligent Manufacturing2007，18，1： | 1 |
| 17 | Effective Product Family Design Using Preference Aggregation显示文摘 | Dai Z Scott M | 2006 | Journal of Me- chanical Design2006，128，4： | 1 |
| 18 | Product platform design through sensitivity analysis and cluster analysis显示文摘 | DAI Z H SCOTT M J | 2007 | Journal of Intelli- gent Manufacturing2007，18，1： | 1 |
| 19 | Laser-Based Field Measurement for a Bridge Finite-Element Model Validation显示文摘 | Kaoshan Dai David Boyajian Wanqiu Liu Shen-En Chen Jeremy Scott Marcus Schmieder | 2013 | Journal of Performance of Constructed Facilities2013，，： | 1 |
| 20 | Product platform design through sensitivity analysis and cluster analysis显示文摘 | DAI Z SCOTT M J | 2007 | Journal of Intelligent Manufacturing2007，18，1： | 1 |
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