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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Coronary stents: Current status显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of American College of Cardiology2010，56，10： | 1 |
| 3 | Superoxide dismutase-rich bacteria: Paradoxical increase in oxidant toxicity显示文摘 | Scot M D Meshnick S R Eaton J W | 1987 | Biol Chem1987，262，： | 1 |
| 4 | Environmental applications of semiconductors显示文摘 | MICHAEL R H SCOT T M CHOI W Y | 1995 | Chem Rev1995，95，： | 1 |
| 5 | Coronary stents: Current status 显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of the American College of Cardiology2010，56，10： | 1 |
| 6 | Functional electrotherapy: stimulation of the perineal nerve synchronized with the swing phase of gait of hemiplegic patients 显示文摘 | LIBERSON W T HOLMQUEST H J SCOT D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 7 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson W T Holmquest H J Scot D | | 0，，： | 1 |
| 8 | The impact of mass transport and methanol crossover on the direct methanol fuel cell显示文摘 | SCOT K TAAMA W M ARGYROPOULOS P | 1999 | Journal of Power Sources1999，83，： | 1 |
| 9 | Feline viruses: Serum-neutralization test for feline panleukopenia 显示文摘 | Csiza C K Gillesple J H Scot F W | 1970 | Cornell Vet1970，60，2： | 1 |
| 10 | Surface complexation and dissolution of hematite by C1-C6 dicarboxylic acids显示文摘 | OWEN W D SCOT Martin | | 0，，23： | 1 |
| 11 | Environmental Application of Semiconductor Photocatalysis显示文摘 | Hoffrnann M R Scot T M Choi W Y | 1995 | Chem Rev1995，95，： | 1 |
| 12 | Feline viruses: Serum-neutralization test for feline panleukopenia显示文摘 | Scot F W Csiza C K Gillesple J H | 1970 | Cornell Vet1970，60，2： | 1 |
| 13 | Results after total knee Replacement with a posterior cruciate substituting prosthesis显示文摘 | Scot W Rubinstein M Scuderi G | 1988 | J B on Joint Surg1988，，： | 1 |
| 14 | Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death显示文摘 | Diwan Abhinav Matkovich Scot J Yuan Qunying Zhao Wen Yatani Atsuko Brown Joan Heller Molkentin Jeffery D Kranias Evangelia G Dorn Gerald W | 2009 | Journal of Clinical Investigation2009，，1： | 1 |
| 15 | Functional electrotherapy: stimulation of the peroneal nervesynchronized with the swing phase of the gait of hemiplegicpatients显示文摘 | LIBERSON W T HOLMQUEST H J SCOT D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 16 | A pressure assisted approach for laser beam weld bonding A1 alloy structure for automobiles显示文摘 | R W Messler Scot Bohnenstiehl John Levene | 2004 | Assembly Automation2004，24，4： | 1 |
| 17 | Environmental Applications of Semiconductor Photocatalysis显示文摘 | Michael R H Scot T M Choi W Y | 1995 | Chem Rev1995，95，1： | 1 |
| 18 | Functional electrotherapy: Stimulation of the peroneal nerve synchro- nized with the swing phase of the gait of hemiplegie patients 显示文摘 | Liherson W T Holmquest H J Scot D | 1961 | Archives of Physical Medicine and Rehabilitation1961，42，： | 1 |
| 19 | Mechani- cal Properties of Lunar Soil: Density, Porosity, Cohesion, and Angle of Friction显示文摘 | MITCHELL J K HOUSTON W N SCOT R F | 1972 | Proc Lunar Sci1972，，3： | 1 |
| 20 | Characterization of an Antioxidant Polylactic Acid (PLA) Film Prepared with-toeopherol, BHT and Polyethylene Glycol Using Film Cast Extruder显示文摘 | YOUNGJAE B YOUNG T K SCOT W | 2010 | Journal of Food Engineering2010，100，： | 1 |
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