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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Quantifying geological uncertainty in metamorphic phase equilibria modelling;a Monte Carlo assessment and implications for tectonic interpretations显示文摘Pseudosection modelling is rapidly becoming an essential part of a petrologist's toolkit and often forms the basis of interpreting the tectonothermal evolution of a rock sample,outcrop,or geological region.Of the several factors that can affect the accuracy and precision of such calculated phase diagrams, 'geological' uncertainty related to natural petrographic variation at the hand sample- and/or thin section-scale is rarely considered.Such uncertainty influences the sample's bulk composition,which is the primary control on its equilibrium phase relationships and thus the interpreted pressure-temperature(P-T) conditions of formation.Two case study examples-a garnet-cordierite granofels and a garnet-staurolite-kyanite schist-are used to compare the relative importance that geological uncertainty has on bulk compositions determined via(1) X-ray fluorescence(XRF) or(2) point counting techniques.We show that only minor mineralogical variation at the thin-section scale propagates through the phase equilibria modelling procedure and affects the absolute P-T conditions at which key assemblages are stable.Absolute displacements of equilibria can approach ±1 kbar for only a moderate degree of modal proportion uncertainty,thus being essentially similar to the magnitudes reported for analytical uncertainties in conventional thermobarometry.Bulk compositions determined from multiple thin sections of a heterogeneous garnet-staurolite-kyanite schist show a wide range in major-element oxides,owing to notable variation in mineral proportions.Pseudosections constructed for individual point count-derived bulks accurately reproduce this variability on a case-by-case basis,though averaged proportions do not correlate with those calculated at equivalent peak P-T conditions for a whole-rock XRF-derived bulk composition.The main discrepancies relate to varying proportions of matrix phases(primarily mica) relative to porphyroblasts(primarily staurolite and kyanite),indicating that point counting preserves small-scale petrographic features that are otherwise averaged out in XRF analysis of a larger sample.Careful consideration of the size of the equilibration volume,the constituents that comprise the effective bulk composition,and the best technique to employ for its determination based on rock type and petrographic character,offer the best chance to produce trustworthy data from pseudosection analysis. | Richard M.Palin Owen M.Weller David J.Waters Brendan Dyck | 2016 | Geoscience Frontiers2016，7，4： | 13 |
| 3 | 整级透平中转静轮缘封严问题研究PartⅠ:封严与入侵显示文摘本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结果表明:静叶尾缘的压力分布是造成燃气入侵的主要原因,即在主流的压力大于密封腔室内压力的区域会出现燃气侵入腔室,造成局部温度过高;主流压力小于腔室内部的压力区域,密封气体能够较好的封严转静间隙。入侵气体和封严气体的掺混主要发生在腔内高半径处并在高速旋转的动盘引发的夹带作用下深入腔室内部低半径处。因此在轮缘密封的结构设计中需要全面的考虑这些因素的影响。 | 吴康 任静 蒋洪德 J Michael Owen | 2014 | 工程热物理学报2014，35，5： | 13 |
| 4 | The significance of clinical practice guidelines on adult varicocele detection and management显示文摘精索静脉曲张是男因素不孕的最普通的可改正的病原学。然而,精索静脉曲张的察觉和管理没被标准化。这在男不孕上关于精索静脉曲张的效果导致了争论的十年,随后,是否修理,导致改进富饶地位。调查精索静脉曲张和 varicocelectomy 的角色的证据的当前的身体弱、冲突。AUA 和 ASRM 拿的位置建议有不够的结果数据支持基于证据的指南,引用过去常提供建议通常具有低优秀水平的电流的证据。在另一方面, EAU 指南为临床上摸得出的精索静脉曲张的管理给水平证据的 1a,与低于正常的精液分析和有的不同 unexplained 富饶联系了。除与临床的精索静脉曲张察觉和管理帮助以外,临床的实践意见陈述和指南试图指导并且加强未来研究的基础结构。我们在实践与他们的申请的焦点在精索静脉曲张和管理察觉考察意见陈述和指南的当前的地位。 | Anand Shridharani Ryan C Owen Osama O Elkelany Edward D Kim | 2016 | Asian Journal of Andrology2016，18，2： | 11 |
| 5 | Modelling internal air systems ingas turbine engines显示文摘Rotating-disc systems can be used to model,experimentally and computationally,the flow and heat transfer that occur inside the internal cooling-air systems of gas turbine engines.These rotating-disc systems have been used successfully to simplify and understand some of the complex flows that occur in internal-air systems,and designers have used this insight to improve the cooling effectiveness,thereby increasing the engine efficiency and reducing the emissions.In this review paper,three important cases are considered:hot-gas ingress;the pre-swirl system;and buoyancy-induced flow.Ingress,or ingestion,occurs when hot gas from the mainstream gas path is ingested into the wheel-space between the turbine disc and its adjacent casing.Rim seals are fitted at the periphery of the system,and sealing flow is used to reduce or prevent ingress.However,too much sealing air reduces the engine efficiency,and too little can cause serious overheating,resulting in damage to the turbine rim and blade roots.Although the flow is three-dimensional and unsteady,there are encouraging signs that simple ‘orifice models’ could be used to estimate the amount of ingress into the wheel-space.In a pre-swirl system,the cooling air for the gas-turbine blades is swirled by stationary nozzles,and the air is delivered to the blades via receiver holes in the rotating turbine disc.Swirling the air reduces its temperature relative to the rotating blades,and the designer needs to calculate the air temperature and pressure drop in the system.The designer also needs to calculate the effect of this swirling flow on the heat transfer from the turbine disc to the air,as this has a significant effect on the temperature distribution and stresses in the disc.Recent experimental and computational studies have given a better understanding of the flow and heat transfer in these systems.Buoyancy-induced flow occurs in the cavity between two co-rotating compressor discs when the temperature of the discs is higher than that of the air in the cavity.Coriolis forces create cyclonic and anti-cyclonic circulation inside the cavity and,as such flows are three-dimensional and unsteady,the heat transfer from the discs to the air is difficult either to compute or to measure.The flow also tends to be unstable and one flow structure can change quasi-randomly to another,which makes it hard for designers of aero-engines to calculate the transient temperature changes and thermal stresses in the discs during take-off,cruise and landing conditions.Although recent CFD research has been successful in computing these flows,it will be many years before the designer can rely on computations unless they have been validated on reliable experimental data. | J Michael Owen | 2007 | 航空动力学报2007，22，4： | 11 |
| 6 | 结直肠癌:鉴于年轻成年人群发病率不断攀升,美国指南敦促从45岁开始进行筛查显示文摘近几十年来,结直肠癌发病率在整体人群中虽呈下降趋势,但在年轻人群中却不断攀升[1]。为此,美国癌症协会新版指南建议将结直肠癌筛查起始年龄下调5年,至45岁该协会表示,自1994年以来,结直肠癌发病率在50岁以下成年人群中增长了51%,这种风险的增加尤其在最年轻的成年人群中表现更为突出。自20世纪80年代中期以来,20岁至39岁成人结肠癌发病率每年增长1.0%~2.4%。同样,直肠癌发病率也表现出了类似的甚至更明显的上升趋势,在1974至2013年,20岁至29岁年轻人群直肠癌发病率每年增长3.2%。 | Owen Dyer 杨广建(译) 王燕(校) | 2019 | 中华外科杂志2019，57，3： | 10 |
| 7 | Temporal Variability in Soil CO_2 Emission in an Orchard Forest Ecosystem显示文摘Temporal variability in soil CO2 emission from an orchard was measured using a dynamic open-chamber system for measuring soil CO2 efflux in Heshan Guangdong Province, in the lower subtropical area of China. Intensive measurements were conducted for a period of 12 months. Soil CO2 emissions were also modeled by multiple regression analysis from daily air temperature, dry-bulb saturated vapor pressure, relative humidity, atmospheric pressure, soil moisture, and soil temperature. Data was analyzed based on soil moisture levels and air temperature with annual data being grouped into either hot-humid season or relatively cool season based on the precipitation patterns. This was essential in order to acquire simplified exponential models for parameter estimation. Minimum and maximum daily mean soil CO2 efflux rates were observed in November and July, with respective rates of 1.98 ± 0.66 and 11.04 ± 0.96 μmol m-2 s-1 being recorded. Annual average soil CO2 emission (FCO2) was 5.92 μmol m-2 s-1. Including all the weather variables into the model helped to explain 73.9% of temporal variability in soil CO2 emission during the measurement period. Soil CO2 efflux increased with increasing soil temperature and soil moisture. Preliminary results showed that Q10, which is defined as the difference in respiration rates over a 10 -C interval, was partly explained by fine root biomass. Soil temperature and soil moisture were the dominant factors controlling soil CO2 efflux and were regarded as the driving variables for CO2 production in the soil. Including these two variables in regression models could provide a useful tool for predicting the variation of CO2 emission in the commercial forest soils of South China . | LI Yue-Lin D. OTIENO K. OWEN ZHANG Yun J. TENHUNEN RAO Xing-Quan LIN Yong-Biao | 2008 | Pedosphere2008，18，3： | 10 |
| 8 | A photothermal reservoir for highly efficient solar steam generation without bulk water显示文摘A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk water.The photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored water.The photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is required.During solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical limit.An extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun irradiation.Practical evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 ppb.Thus the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination. | Xuan Wu Ting Gao Chenhui Han Jingsan Xu Gary Owens Haolan Xu | 2019 | Science Bulletin2019，64，21： | 9 |
| 9 | Influence of Indian mustard (Brassica juncea) on rhizosphere soil solution chemistry in long-term contaminated soils:A rhizobox study显示文摘This study investigated the influence of Indian mustard (Brassica juncea) root exudation on soil solution properties (pH, dissolved organic carbon (DOC), metal solubility) in the rhizosphere using a rhizobox. Measurement was conducted following the cultivation of Indian mustard in the rhizobox filled four different types of heavy metal contaminated soils (two alkaline soils and two acidic soils). The growth of Indian mustard resulted in a significant increase (by 0.6 pH units) in rhizosphere soil solution pH of acidic soils and only a slight increase (<0.1 pH units) in alkaline soils. Furthermore, the DOC concentration increased by 17-156 mg/L in the rhizosphere regardless of soil type and the extent of contamination, demonstrating the exudation of DOC from root. Ion chromatographic determination showed a marked increase in the total dissolved organic acids (OAs) in rhizosphere. While root exudates were observed in all soils, the amount of DOC and OAs in soil solution varied considerably amongst different soils, resulting in significant changes to soil solution metals in the rhizosphere. For example, the soil solution Cd, Cu, Pb, and Zn concentrations increased in the rhizosphere of alkaline soils compared to bulk soil following plant cultivation. In contrast, the soluble concentrations of Cd, Pb, and Zn in acidic soils decreased in rhizosphere soil when compared to bulk soils. Besides the influence of pH and DOC on metal solubility, the increase of heavy metal concentration having high stability constant such as Cu and Pb resulted in a release of Cd and Zn from solid phase to liquid phase. | Kwon-Rae Kim Gary Owens Soon-lK Kwon | 2010 | Journal of Environmental Sciences2010，22，1： | 8 |
| 10 | 亚洲土壤对酸化的敏感性:现状与展望显示文摘一直以来,研究者发现在中国南方及东南亚地区存在土壤酸化超出标准稳定状态的临界载荷的现象,但尚无证据能够说明土壤酸化在中国境外的影响。本研究介绍了一种在硫(S)、氮(N)和钙(Ca)的未来潜在排放情景下,亚洲土壤敏感性对酸沉降的时间效应的计算方法。这种方法通过对亚洲可用性数据的匹配,制作了区域尺度图,估算了在相应的酸沉降条件下,土壤盐基饱和度需要多少时间(年)能达到20%的临界上限。研究结果表明,南亚、东南亚和东亚的土壤类型敏感地区,包括中国南部部分地区,以及缅甸、海南、老挝、泰国、越南和印度西高止山脉等,达到显著酸化的程度可能需要0~50年(尺度),这主要取决于当地的管理水平、生物和非生物的因素等。为了更明确地评估风险,需要贯穿亚洲代表不同植被和土壤类型及管理制度的典型区域的定点观测数据,如土壤化学、沉降(尤其是相应的阳离子沉降)、土壤和生态系统中硫、氮含量、可收获的生物量及风化速率等。本文介绍的国家和区域评估土壤的简单方法,可以对土壤酸化相关的影响时间尺度进行正确评价,有助于下一步研究,通过相关措施可降低酸化的风险。 | W. Kevin Hicks Johan C. I. Kuylenstierna Anne Owen Frank Dentener Hans-Martin Seip Henning Rodhe 马泽清(译) 哈艳梅(译) | 2008 | AMBIO-人类环境杂志2008，37，4： | 8 |
| 11 | 胶北粉子山群石榴云母片岩的三叠纪独居石年龄及其地质意义显示文摘胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和CaO含量变化特征表明其核部到边部温度先升高后降低,对应进变质及退变质过程。根据原位独居石Y元素成分面扫描图显示,部分独居石颗粒由核部到边部Y含量呈现逐渐降低趋势,说明测得的232.6±1.1Ma^229.5±3.7Ma的独居石U-Pb年龄,对应石榴石的进变质生长过程。结合1869±72Ma的锆石U-Pb年龄数据,可推断粉子山群石榴云母片岩至少经历了古元古代及三叠纪两期变质事件的改造。粉子山群石榴云母片岩卷入了苏鲁超高压变质带的俯冲碰撞造山事件。电子探针成分分析结果表明粉子山群石榴云母片岩中的石榴石属于铁铝榴石,反映出经受中级区域变质作用的特征。说明粉子山群石榴云母片岩虽然参与了三叠纪苏鲁超高压变质带的俯冲碰撞造山过程,但俯冲深度较浅。这可用大陆俯冲过程中上盘的俯冲剥蚀来解释,并可为陆-陆碰撞俯冲剥蚀模式提出的扬子板片在240~220Ma的深俯冲作用过程中拽动胶北地块向下俯冲又折返的运动过程提供佐证,但胶北地块是否经历了深俯冲超高压变质作用,还需要进一步验证。 | 曹汇 VERVOORT Jeff 王达 李广旭 NEILL Owen | 2016 | 岩石学报2016，32，12： | 7 |
| 12 | Chemodynamics of heavy metals in long-term contaminated soils:Metal speciation in soil solution显示文摘The concentration and speciation of heavy metals in soil solution isolated from long-term contaminated soils were investigated. The soil solution was extracted at 70% maximum water holding capacity (MWHC) after equilibration for 24 h. The free metal concentrations (Cd2+, Cu2+, Pb2+, and Zn2+) in soil solution were determined using the Donnan membrane technique (DMT). Initially the DMT was validated using artificial solutions where the percentage of free metal ions were significantly correlated with the percentages predicted using MINTEQA2. However, there was a significant difference between the absolute free ion concentrations predicted by MINTEQA2 and the values determined by the DMT. This was due to the significant metal adsorption onto the cation exchange membrane used in the DMT with 20%, 28%, 44%, and 8% mass loss of the initial total concentration of Cd, Cu, Pb, and Zn in solution, respectively. This could result in a significant error in the determination of free metal ions when using DMT if no allowance for membrane cation adsorption was made. Relative to the total soluble metal concentrations the amounts of free Cd2+ (3%-52%) and Zn2+ (11%-72%) in soil solutions were generally higher than those of Cu2+ (0.2%-30%) and Pb2+ (0.6%-10%). Among the key soil solution properties, dissolved heavy metal concentrations were the most significant factor governing free metal ion concentrations. Soil solution pH showed only a weak relationship with free metal ion partitioning coefficients (Kp) and dissolved organic carbon did not show any significant influence on Kp. | Kwon-Rae Kim Gary Owens | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 13 | Computed tomography and patient risk:Facts,perceptions and uncertainties显示文摘Since its introduction in the 1970s, computed tomography(CT) has revolutionized diagnostic decision-making. One of the major concerns associated with the widespread use of CT is the associated increased radiation exposure incurred by patients. The link between ionizing radiation and the subsequent development of neoplasia has been largely based on extrapolating data from studies of survivors of the atomic bombs dropped in Japan in 1945 and on assessments of the increased relative risk of neoplasia in those occupationally exposed to radiation within the nuclear industry. However, the association between exposure to low-dose radiation from diagnostic imaging examinations and oncogenesis remains unclear. With improved technology, significant advances have already been achieved with regards to radiation dose reduction. There are several dose optimization strategies available that may be readily employed including omitting unnecessary images at the ends of acquired series, minimizing the number of phases acquired, and the use of automated exposure control as opposed to fixed tube current techniques. In addition, new image reconstruction techniques that reduce radiation dose have been developed in recent years with promising results. These techniques use iterative reconstruction algorithms to attain diagnostic quality images with reduced image noise at lower radiation doses. | Stephen P Power Fiachra Moloney Maria Twomey Karl James Owen J O'Connor Michael M Maher | 2016 | World Journal of Radiology2016，8，12： | 7 |
| 14 | 跨界水道环境影响评价的法律与实践显示文摘目前在众多已生效的国际条约中均包含着在特定情况下进行环境影响评价的条款。在国际法中,至少在跨界环境影响方面,优先跨界环境影响评价的要求已被广泛承认和接受,其实践已经形成了国际法惯例。因而,在一些国际争端中,国家已经依据现有的一般要求执行环境影响评价。环境影响评价制度也被运用到跨界水道利用领域,双边和多边协议规定了一些形式的跨界环境影响评价。在实践中,对跨界水道利用的投资项目也以执行环境影响评价为必要条件。 | Owen McIntyre 秦天宝 蒋小翼 | 2012 | 江西社会科学2012，32，2： | 6 |
| 15 | Disposal and Use of Sewage on Agricultural Lands in Pakistan: A Review显示文摘Raw sewage is widely used on agricultural soils in urban areas of developing countries to meet water shortages. Although it is a good source of plant nutrients, such sewage also increases the heavy metal load to soils, which may impact the food chain. Management options for sewage contaminated soils includes addition of nontoxic compounds such as lime, calcium sulfate and organic matter, which form insoluble metal complexes, thus reducing metal phytoavailability to plants. In this paper we review the variation in irrigation quality of sewage at different sites and its impact on the quality of soils and vegetables. Although quality of sewage was highly variable at source, yet the effluent from food industries was relatively safe for irrigation. In comparison effluent samples collected from textile, dyeing, calendaring, steel industry, hospitals and clinical laboratories, foundries and tanneries were hazardous with respect to soluble salts, sodium adsorption ratio and heavy metals like zinc, copper, iron, manganese, nickel, cobalt and cadmium. The sewage quality in main drains was better than that at the industry outlet, but was still not safe for irrigation. In general, higher accumulation of metals in fruits and vegetable roots was recorded compared to that in plant leaves. Edible parts of vegetables (fruits and/or leaves) accumulated metals more than the permissible limits despite the soils contained ammonium bicarbonate diethylenetriaminepentaacetic acid extractable metals within a safe range. In either case further scientific investigations are needed to ensure safe management strategies. Cadmium appeared to be the most threatening metal especially in leafy vegetables. It is advisable to avoid leafy vegetables cultivation in sewage irrigated areas everywhere to restrict its entry into food chain. | G. MURTAZA A. GHAFOOR M. QADIR G. OWENS M. A. AZIZ M. H. ZIA SAIFULLAH | 2010 | Pedosphere2010，20，1： | 6 |
| 16 | Oxidative stress modulation in hepatitis C virus infected cells显示文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells. | Sonia A Lozano-Sepulveda Owen L Bryan-Marrugo Carlos Cordova-Fletes Maria C Gutierrez-Ruiz Ana M Rivas-Estilla | 2015 | World Journal of Hepatology2015，7，29： | 6 |
| 17 | Is resource allocation and grain yield of rice altered by inoculation with arbuscular mycorrhizal fungi?显示文摘Aims our study quantified the combined effects of fertilization and inoculation with arbuscular mycorrhizal fungi(AMF)on grain yield and allocation of biomass and nutrients in field-grown rice(Oryza sativa l.).Methods a two-factor experiment was conducted at a field site in northeast of China(in shuangcheng,Heilongjiang Province,songhua river basin):six nitrogen-phosphorus-potassium fertilizer levels were provided(0,20,40,60,80 and 100%of the local norm of ferti-lizer supply),with or without inoculation with Glomus mosseae.at maturity,we quantified the percentage of root length colonization by AMF,grain yield,shoot:root ratios,shoot N and P contents and nutrients allocated to panicles,leaves and stems.Important Findingsas expected,inoculation resulted in greatly increased AMF colo-nization,which in turn led to higher shoot:root ratios and greater shoot N contents.shoot:root ratios of inoculated rice increased with increasing fertilization while there was a significant interaction between fertilization and inoculation on shoot:root ratio.additionally,a F inoculation increased panicle:shoot ratios,panicle N:shoot N ratios and panicle P:shoot P ratios,especially in plants grown at low fertilizer levels.Importantly,inoculated rice exhibited higher grain yield,with the maximum improvement(near 62%)at the lower fertilizer end.our results showed that(i)AMFinoculated plants conform to the functional equilibrium theory,albeit to a reduced extent compared to non-inoculated plants and(ii)AMF inoculation resulted in greater allocation of shoot biomass to panicles and increased grain yield by stimulating N and P redis-tribution to panicles. | Shujuan Zhang Li Wang Fang Ma Keith J.Bloomfield Jixian Yang Owen K.Atkin | 2015 | Journal of Plant Ecology2015，8，4： | 5 |
| 18 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 19 | Lipopolysaccharide inhibits or accelerates biomedical titanium corrosion depending on environmental acidity显示文摘Titanium and its alloys are routinely used as biomedical implants and are usually considered to be corrosion resistant under physiological conditions. However, during inflammation, chemical modifications of the peri-implant environment including acidification occur. In addition certain biomolecules including lipopolysaccharide(LPS), a component of Gram-negative bacterial cell walls and driver of inflammation have been shown to interact strongly with Ti and modify its corrosion resistance. Gram-negative microbes are abundant in biofilms which form on dental implants. The objective was to investigate the influence of LPS on the corrosion properties of relevant biomedical Ti substrates as a function of environmental acidity. Inductively coupled plasma mass spectrometry was used to quantify Ti dissolution following immersion testing in physiological saline for three common biomedical grades of Ti(ASTM Grade 2, Grade 4 and Grade 5). Complementary electrochemical tests including anodic and cathodic polarisation experiments and potentiostatic measurements were also conducted. All three Ti alloys were observed to behave similarly and ion release was sensitive to p H of the immersion solution. However, LPS significantly inhibited Ti release under the most acidic conditions(p H 2), which may develop in localized corrosion sites, but promoted dissolution at p H 4–7, which would be more commonly encountered physiologically.The observed pattern of sensitivity to environmental acidity of the effect of LPS on Ti corrosion has not previously been reported. LPS is found extensively on the surfaces of skin and mucosal penetrating Ti implants and the findings are therefore relevant when considering the chemical stability of Ti implant surfaces in vivo. | Fei Yu Owen Addison Stephen J Baker Alison J Davenport | 2015 | International Journal of Oral Science2015，7，3： | 5 |
| 20 | Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk显示文摘We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also beneficial.To test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)posttreatment.We then collected blood and liver at 6,24,and 52 h.Post-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC alone.Interestingly,PA did not affect canonical mechanisms of APAP toxicity.Instead,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the liver.Consistent with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated mice.Furthermore,PA failed to protect against APAP in IL-6-deficient animals.Interestingly,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating IL-6.Surprisingly,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short half-life.These data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model. | Melissa M.Clemens Stefanie Kennon-McGill Joel H.Vazquez Owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMcCullough Laura P.James Brian N.Finck Mitchell R.McGill | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
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