|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Coronary stents: Current status显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of American College of Cardiology2010，56，10： | 1 |
| 3 | Superoxide dismutase-rich bacteria: Paradoxical increase in oxidant toxicity显示文摘 | Scot M D Meshnick S R Eaton J W | 1987 | Biol Chem1987，262，： | 1 |
| 4 | Stress-strain behavior of concrete confined by overlapping hoops at low and high strain rates 显示文摘 | SCOT'F B D PARK R PRISETLEY M J N | 1982 | ACI Journal1982，79，2： | 1 |
| 5 | Adult mes- enchymal stem cells: differentiation potential and therapeutic applications显示文摘 | JACKSON L JONES D R SCOTTING P | 2007 | J Postgrad Med2007，53，2： | 1 |
| 6 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 7 | Adult mesenchymal stem cells; differentiation potential and therapeutic applications显示文摘 | Jackson L Jones D R Scotting P | 2007 | J Postgrad Med2007，53，2： | 1 |
| 8 | Coronary stents: Current status 显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of the American College of Cardiology2010，56，10： | 1 |
| 9 | Functional electrotherapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients 显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 10 | A modeling study on the early electrical evelopment of tropical convection: Continental and oceanic(monsoon)storms显示文摘 | S A Rutledge D F Richard | 1974 | Mon Wea Rev1974，122，： | 1 |
| 11 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson WT Holmquest H J Scot D | 1961 | Arch Phys Med Rehabil1961，42，2： | 1 |
| 12 | Functional electrotherapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 13 | Dispusition kinetics of ropivacaine in humans 显示文摘 | Lee A Fagan D Lamont M Tucker GT Halldin M Scot DB | 1989 | J Anesth Analg1989，69，6： | 1 |
| 14 | Functional electrotherapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 15 | Functional electrotherapy: stimulation of the perineal nerve synchronized with the swing phase of gait of hemiplegic patients 显示文摘 | LIBERSON W T HOLMQUEST H J SCOT D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 16 | A meta-analysis of neuropsy - chological change to clozapine, olanzapine, quetiapine and risperidone in schizophrenia 显示文摘 | Neil D Woodward Scot E | 2005 | Int J Neour2005，8，： | 1 |
| 17 | Role stress and career satisfaction among registered nurses by work shift paterns显示文摘 | Hoffman A J Scot L D | 2003 | Nurs Adm2003，33，6： | 1 |
| 18 | Functional electrotherapy: stimulation of the peroneal nerve synchro- nized with the swing phase of the gait of hemiplegic pa- tients显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Med Rehabil1961，42，10： | 1 |
| 19 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson W T Holmquest H J Scot D | | 0，，： | 1 |
| 20 | Functional electro- therapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients 显示文摘 | Liberson WT Holmquest HJ Scot D | 1961 | Arch Phys Rehabil1961，42，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员