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| 1 | Current management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer worldwide and leading cause of death among patients with cirrhosis.Treatment guidelines are based according to the Barcelona Clinic Liver Cancer staging system.The choice among therapeutic options that include liver resection,liver transplantation,locoregional,and systemic treatments must be individualized for each patient.The aim of this paper is to review the outcomes that can be achieved in the treatment of HCC with the heterogeneous therapeutic options currently available in clinical practice. | Parissa Tabrizian Sasan Roayaie Myron E Schwartz | 2014 | World Journal of Gastroenterology2014，20，30： | 18 |
| 2 | Effect of vildagliptin as add-on therapy to a low-dose metformin显示文摘AIM:To evaluate the efficacy and safety of the addition of vildagliptin to low-dose metformin and compare it to an uptitration of metformin in type 2 diabetes mellitus(T2DM) patients who have inadequate control with metformin monotherapy.METHODS:Eligible patients were randomized to receive vildagliptin 100 mg qd or metformin(500 mg qd for 2 wk and then 500 mg bid) added to open label me tformin 500 mg bid for the 24 wk.The primary endpoi nt was baseline to endpoint hemoglobin A1c(HbA1c) change.RESULTS:The adjusted mean change from baseline in HbA1c at the 24th wk was-0.51% in the vildagliptin/metformin group(mean baseline HbA1c:7.4%) and-0.37% in the metformin monothera py group(mean baseline HbA1c:7.3%).The mean diffe rence was-0.14% with 95% Confidence Interval(-0.24%,-0.05%).As non-inf e riority(margin of 0.4%) was achieved,a test for superiority was performed.This test showed statistically significant superiority of the combination over monotherapy group(P = 0.002).Gastrointestinal(GI) adverse events were signif icantly more frequent in the metformin group than the combin ation group(21.0% vs 15.4%,P = 0.032).CONCLUSION:In patients with T2DM inadequately controlled with metformin up to 1000 mg daily,the addition of vildagliptin 100 mg daily achieved larger HbA1c reduction with fewer GI events than with increa sing the metformin dose. | Claudia Filozof Sherwyn Schwartz James E Foley | 2010 | World Journal of Diabetes2010，1，1： | 8 |
| 3 | 肝的周期性的巨大的 hemangiomas : 有文学评论的二个稀罕案例的报告显示文摘 Most hepatic hemangiomas(HHs) are small,asymptomatic and do not require clinical intervention.Surgical resection is only indicated for symptomatic hemangiomas.We report here cases of recurrent HHs in 2 women of 37 and 40 years old,who initially presented with abdominal pain and mass.Radiological examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter,respectively.Surgical liver segmental resections were performed in both,and the diagnosis of cavernous hemangioma was confirmed.Both patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial surgery.In the first patient,a 15 cm recurrent hemangioma was resected,but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe,which was not amendable for resection.In the second patient,a 16 cm hemangioma was seen on radiogram,and because the lesion was not symptomatic,conservative observation was offered.Recurrence after liver resection of giant hemangioma is extremely rare.The pathogenesis of tumor progression and recurrence is unknown,as is the management of these patients with recurrent hemangioma,particularly when it is extensive and unresectable. | Hongfa Zhu Khaled Obeidat Jie Ouyang Sasan Roayaie Myron E Schwartz Swan N Thung | 2012 | World Journal of Gastrointestinal Surgery2012，4，11： | 5 |
| 4 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 5 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 6 | 子宫颈癌累及泌尿生殖道:潜在的诊断困境显示文摘Schwartz L E, Khani F, Bishop J A, et al. Carcinoma of the u- terine cervix involving the genitourinary tract: a potential diag- nostic dilemma. Am J Surg Pathol, 2016,40(1) :27 -35.有关子宫颈癌继发累及泌尿生殖道的记载非常少见。由于形态学上这些肿瘤可以类似于尿路上皮癌,也可以与膀胱的原发性鳞状细胞癌和原发性腺癌非常相似,故诊断具有极大的挑战性。作者收集了约翰霍普金斯医院从1984年至今的泌尿生殖器咨询案例,主要包括原发性膀胱癌与子宫颈癌继发性累及膀胱的鉴别诊断病例。作者确定了10例满足这些标准的病例。 | Schwartz L E Khani F Bishop J A 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，2： | 3 |
| 7 | Cardiovascular physiology in the older adults显示文摘 | Xuming Dai Scott L Hummel Jorge B Salazar George E Taffet Susan Zieman Janice B Schwartz | 2015 | Journal of Geriatric Cardiology2015，12，3： | 2 |
| 8 | Consistent regulatory policy under uncertainty显示文摘 | Brennan M J Schwartz E S | 1982 | The Bell Journal of Economics1982，13，2： | 2 |
| 9 | Ankle arthrodesis: long-term follow-up with gait analysis 显示文摘 | Mazur JM Schwartz E Simon SR | 1979 | J Bone Joint Surg(Am)1979，61，： | 2 |
| 10 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 11 | Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma显示文摘 | Mulayim N Foster Silver D Schwartz P E | 2004 | Gynecol Oncol2004，93，3： | 2 |
| 12 | SARS-COV-2 infection(coronavirus disease 2019)for the gastrointestinal consultant显示文摘The current pandemic due to the severe acute respiratory syndrome coronavirus 2 has caused an extreme burden for health care systems globally,and the number of cases is expected to continue to increase,at least in the immediate future.The virus is estimated to have infected more than 1.5 million individuals.The available reports suggest that gastrointestinal(GI)involvement in coronavirus disease 2019(COVID-19)is common and in some cases the GI symptoms may precede the respiratory symptoms.In addition to direct effects of severe acute respiratory syndrome coronavirus 2,the infected patients remain at risk for the complications commonly managed by gastroenterology and hepatology consultants.The most commonly reported GI manifestation of COVID-19 is diarrhea,which is reported in a third to up to more than half of the patients.Mild to moderate elevation of the liver enzymes are also common,although no case of acute liver failure has been reported so far.Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients.Although the diagnosis of the infection is currently based on RNA analysis in respiratory samples,the available literature on fecal shedding of this virus suggests that fecal RNA testing might prove to be a useful diagnostic test.It is reasonable to delay all non-urgent endoscopic procedures during the peak of the pandemic and use additional protective equipment such as N95 respirators during endoscopy while most patients can be considered high risk for having been exposed to the virus. | Kaveh Hajifathalian Srihari Mahadev Robert E Schwartz Shawn Shah Kartik Sampath Felice Schnoll-Sussman Robert S Brown Jr David Carr-Locke David E Cohen Reem Z Sharaiha | 2020 | World Journal of Gastroenterology2020，26，14： | 2 |
| 13 | The sound war显示文摘 | SCHWARTZ E I | 2004 | Technology Review2004，107，4： | 1 |
| 14 | A novel GABRG2 mutation assotiated with febrile seizures显示文摘 | AUDENAERTD SCHWARTZ E CLAEVS KG | 2006 | Neurology2006，67，4： | 1 |
| 15 | Ankle arthrodesis: long-term follow-up with gait analysis 显示文摘 | Mazur JM Schwartz E Sheldon RE | 1976 | J Bone Joint Surg (Am)1976，61，： | 1 |
| 16 | Convertible bonds: valuation and optimal strategies or call and conversion显示文摘 | Brennan M J Schwartz E S | 1977 | Journal of Finance1977，32，： | 1 |
| 17 | Lead-induced anemia: doseresponse relationships and evidence for a threshold 显示文摘 | Schwartz J Landrigan P J Baker E L | 1990 | American Journal Public Health1990，80，： | 1 |
| 18 | Stochastic Convenience Yield and the Pricing of Oil Contingent Claims 显示文摘 | Gibson R Schwartz E S | 1990 | The Journal of Finance1990，65，3： | 1 |
| 19 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 20 | Contribution of technical materials to the mobile fraction of metals in urban soils in Marrakech (Morocco) 显示文摘 | Khalil H E Schwartz C Elhamiani O | 2008 | Journal of Soils and Sediments2008，8，1： | 1 |
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