|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 2 | Mitochondrial iron sequestration in dopamine-challeged astroglia: role of heine oxygenase-1 and the permeability transition pore 显示文摘 | Schipper H Bernier L Mehindate K | 1999 | Neurochem1999，72，5： | 1 |
| 3 | 显示文摘 | Degnan T F Chitnis G K Schipper P H | 2000 | Microporous Me soporous Mater2000，3536，： | 1 |
| 4 | Procedure for in-use calibration of triaxial accelerome- ters in medical applications显示文摘 | LOTTERS J C SCHIPPER J VELTINK P H | 1998 | Sensors and Actuators A:Physical1998，61，1： | 1 |
| 5 | Can you have dementia with MMSE score of 30? 显示文摘 | Shiroky JS Schipper HM Bergman H | 2007 | Am J Alzheimers Dis Other Demen2007，22，5： | 1 |
| 6 | Measuring the quality of life of cancer patients: the functional lining index-cancer: development and validation显示文摘 | Schipper H Clinch J McMurray A | 1984 | Journal of Clinical Ontology1984，2，5： | 1 |
| 7 | Neural heine oxygenase-1 expression in idiopathic Parkinson' s disease 显示文摘 | Schipper H M Liberman A Stopa E G | 1998 | Exp Neurol1998，150，1： | 1 |
| 8 | Measuring the quality of life of cancer patients:Development of a comprehensive quality of life measurement tool显示文摘 | Schipper H Clinch J McMurray h | 1990 | CARES Oncology1990，，4： | 1 |
| 9 | Measuring the quality of life in cancer patients: The Functional Living Index-cancer: development and validation 显示文摘 | Schipper H Clineh J | 1984 | J Clin Oncol1984，2，： | 1 |
| 10 | Proposed elimination of the term endorhizosphere显示文摘 | Kleopper J W Schippers B Bakker P A H M | 1992 | Phytopathology1992，82，： | 1 |
| 11 | Can the Proximal Femoral Nail be Improved?显示文摘 | Inger B. 1 8 Phone Fax e-mail: Schipper MD PhD Roger K. J. Simmermacher Tobias Hüttl R?bi Frigg Peter Messmer Michael Schütz Andreas Lenich Chris Werken | 2005 | European Journal of Trauma2005，，3： | 1 |
| 12 | Why measure quality of life显示文摘 | Schipper H | 1983 | Can Med Assoc J1983，128，12： | 1 |
| 13 | Proposed Elimination of the Term Endorhizos-phere显示文摘 | KIEOPPER J W SCHIPPER B BAKKER P A H M | 1992 | Phytopathol1992，，82： | 1 |
| 14 | Treating cancer:is kill cure?显示文摘 | Schipper H | 1994 | Ann Acad Med Singapore1994，23，3： | 1 |
| 15 | History of ZSM -5 fluidcatalytic cracking additive development at mobil 显示文摘 | Degnan T F Chitnis G K’Schipper P H | 2000 | MicroporousMesoporous Mater2000，，3536： | 1 |
| 16 | Measuring the quality of life of cancer patients: the Functional Living Index-cancer:development and validation显示文摘 | Schipper H Clinch J McMurray A | 1984 | J Clin Oncol1984，2，5： | 1 |
| 17 | Treating cancer: is kill cure?显示文摘 | SCHIPPER H | 1994 | Ann Acad Med Singapore1994，23，3： | 1 |
| 18 | Guidelines and caveats for quality of life measurement in clinical practice and research显示文摘 | Schipper H | 1990 | Oncology1990，4，： | 1 |
| 19 | A framework for integrated biophysical and economic landuseanalysis at different scales 显示文摘 | Jansen H G P Schipper R A | 1999 | Agriculture Ecosystems & Environment1999，75，1： | 1 |
| 20 | Two-phase cluster model in riser reactors, impact of radial density distribution on yields显示文摘 | Fligner M Schipper P H Sapre AV | 1994 | Chemical Engineering Science1994，49，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员