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| 1 | Systemic inflammation and immune response after laparotomy vs laparoscopy in patients with acute cholecystitis, complicated by peritonitis显示文摘AIM: To evaluate acute cholecystitis, complicated by peritonitis, acute phase response and immunological status in patients treated by laparoscopic or open approach. METHODS: From January 2002 to May 2012, we conducted a prospective randomized study on 45 consecutive patients (27 women, 18 men; mean age 58 years). These subjects were taken from a total of 681 patients who were hospitalised presenting similar preoperative findings: acute upper abdominal pain with tenderness, involuntary guarding under the right hypochondrium and/or in the flank; fever higher than 38 ℃, leukocytosis greater than 10 × 10 9 /L or both, and ultrasonographic evidence of calculous cholecystitis possibly complicated by peritonitis. These patients had undergone cholecystectomy for acute calculous cholecystitis,complicated by bile peritonitis. Randomly, 23 patients were assigned to laparoscopic cholecystectomy (LC), and 22 patients to open cholecystectomy (OC). Blood samples were collected from all patients before operation and at days 1, 3 and 6 after surgery. Serum bacteraemia, endotoxaemia, white blood cells (WBCs), WBC subpopulations, human leukocyte antigen-DR (HLA-DR), neutrophil elastase, interleukin-1 (IL-1) and IL-6, and C-reactive protein (CRP) were measured at 0, 30, 60, 90, 120 and 180 min, at 4, 6, 12, 24 h, and then daily (8 A.M.) until post-operative day 6.RESULTS: The two groups were comparable in the severity of peritoneal contamination as indicated by the viable bacterial count (open group = 90% of positive cultures vs laparoscopic group = 87%) and endotoxin level (open group = 33.21 ± 6.32 pg/mL vs laparoscopic group = 35.02 ± 7.23 pg/mL). Four subjects in the OC group (18.1%) and 1 subject (4.3%) in the LC group (P < 0.05) developed intra-abdominal abscess. Severe leukocytosis (range 15.8-19.6/mL) was observed only after OC but not after LC, mostly due to an increase in neutrophils (days 1 and 3, P < 0.05). This value returned to the normal range within 3-4 d after LC and 5-7 d after OC. Other WBC types and lymphocyte subpopulations showed no significant variation. On the first day after surgery, a statistically significant difference was observed in HLA-DR expression between LC (13.0 ± 5.2) and OC (6.0 ± 4.2) (P < 0.05). A statistically significant change in plasma elastase concentration was recorded post-operatively at days 1, 3, and 6 in patients from the OC group when compared to the LC group (P < 0.05). In the OC group, the serum levels of IL-1 and IL-6 began to increase considerably from the first to the sixth hour after surgery. In the LC group, the increase of serum IL-1 and IL-6 levels was delayed and the peak values were notably lower than those in the OC group. Significant differences between the groups, for these two cytokines, were observed from the second to the twenty-fourth hour (P < 0.05) after surgery. The mean values of serum CRP in the LC group on post-operative days (1 and 3) were also lower than those in the OC group (P < 0.05). Systemic concentration of endotoxin was higher in the OC group at all intra-operative sampling times, but reached significance only when the gallbladder was removed (OC group = 36.81 ± 6.4 ρg/mLvs LC group = 16.74 ± 4.1 ρg/mL, P < 0.05). One hour after surgery, microbiological analysis of blood cultures detected 7 different bacterial species after laparotomy, and 4 species after laparoscopy (P < 0.05). CONCLUSION: OC increased the incidence of bacteraemia, endotoxaemia and systemic inflammation compared with LC and caused lower transient immunological defense, leading to enhanced sepsis in the patients examined. | Federico Sista Mario Schietroma Giuseppe De Santis Antonella Mattei Emanuela Marina Cecilia Federica Piccione Sergio Leardi Francesco Carlei Gianfranco Amicucci | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 23 |
| 2 | Surface latent heat flux anomalies before the M_S 7.1 New Zealand earthquake 2010显示文摘By analyzing surface latent heat flux (SLHF) data from the NCEP/NCAR Reanalysis Project for the period three months before and after the Sept. 3, 2010 M S 7.1 New Zealand earthquake, an isolated SLHF positive anomaly on Aug. 1, 2010 was found with a high value of about 160 W/m 2 to the northeast of the epicenter. Historical data, background pixels, and wavelet transforms of time series were comprehensively analyzed to study the spatiotemporal features of the SLHF anomaly. After removing the influences of wind speed and cloud cover, the key factor leading to local SLHF anomalies is the surface temperature increment. Combined with GPS displacement observations and tectonic settings, we determined that the physical mechanism of the SLHF anomaly could possibly be attributed to hot underground materials related to high-temperature and high-pressure upwelling from the deep crust and mantle along the nearby subduction zone, thereby explaining the local temperature increment to the northeast of the epicenter, as well as in the center of the North Island and the southwest of the South Island. Furthermore, it changed the specific humidity between the ground and surface air, causing the local SLHF increment. | QIN Kai WU LiXin DE SANTIS Angelo WANG He | 2011 | Chinese Science Bulletin2011，56，31： | 8 |
| 3 | Cholangiocarcinoma and malignant bile duct obstruction: A review of last decades advances in therapeutic endoscopy显示文摘In the last decades many advances have been achieved in endoscopy, in the diagnosis and therapy of cholangiocarcinoma, however blood test, magnetic resonance imaging, computed tomography scan may fail to detect neoplastic disease at early stage, thus the diagnosis of cholangiocarcinoma is achieved usually at unresectable stage. In the last decades the role of endoscopy has moved from a diagnostic role to an invaluable therapeutic tool for patients affected by malignant bile duct obstruction. One of the major issues for cholangiocarcinoma is bile ducts occlusion, leading to jaundice, cholangitis and hepatic failure. Currently, endoscopy has a key role in the work up of cholangiocarcinoma, both in patients amenable to surgical intervention as well as in those unfit for surgery or not amenable to immediate surgical curative resection owing to locally advanced or advanced disease, with palliative intention. Endoscopy allows successful biliary drainage and stenting in more than 90% of patients with malignant bile duct obstruction, and allows rapid reduction of jaundice decreasing the risk of biliary sepsis. When biliary drainage and stenting cannot be achieved with endoscopy alone, endoscopic ultrasound-guided biliary drainage represents an effective alternative method affording successful biliary drainage in more than 80% of cases. The purpose of this review is to focus on the currently available endoscopic management options in patients with cholangiocarcinoma. | Helga Bertani Marzio Frazzoni Santi Mangiafico Angelo Caruso Mauro Manno Vincenzo Giorgio Mirante Flavia Pigò Carmelo Barbera Raffaele Manta Rita Conigliaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 8 |
| 4 | Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection显示文摘Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Roberta Maselli Grace Santi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 7 |
| 5 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 6 | Post-transplantation hepatocellular carcinoma recurrence: Patterns and relation between vascularity and differentiation degree显示文摘AIM: To evaluate the relationship between hepatocellular carcinoma(HCC) vascularity and grade; to describe patterns and vascular/histopathological variations of post-transplantation recurrence.METHODS: This retrospective study included 165 patients(143 men, 22 women; median age 56.8 years, range 28-70.4 years) transplanted for HCC who had a follow-up period longer than 2 mo. Pre-transplantation dynamic computed tomography or magnetic resonance examinations were retrospectively reviewed, classifying HCC imaging enhancement pattern into hypervascular and hypovascular based on presence of wash-in during arterial phase. All pathologic reports of the explanted livers were reviewed, collecting data about HCC differentiation degree. The association between imaging vascular pattern and pathological grade was estimated using the Fisher exact test. All follow-up clinical and imaging data were reviewed for evidence of recurrence. Recurrence rate was calculated and imaging features of recurrent tumor were collected, classifying early and late recurrences based on timing(< or ≥ 2 years after transplantation) and intrahepatic, extrahepatic and both intrahepatic and extrahepatic recurrences based onlocation. All intrahepatic recurrences were classified as hypervascular or hypovascular and the differentiation degree was collected where available. The presence of variations in imaging enhancement pattern and pathological grade between the primary tumor and the intrahepatic recurrence was evaluated and the association between imaging and histopatholgical variations was estimated by using the χ2 test. RESULTS: Of the 163 patients with imaging evidence of viable tumor, 156(95.7%) had hypervascular and 7(4.3%) hypovascular HCC. Among the 125 patients with evidence of viable tumor in the explanted liver, 19(15.2%) had grade 1, 56(44.8%) grade 2, 40(32%) grade 3 and 4(3.2%) grade 4 HCC, while the differentiation degree was not assessable for 6 patients(4.8%). A significant association was found between imaging vascularity and pathological grade(P = 0.035). Post-transplantation recurrence rate was 14.55%(24/165). All recurrences occurred in patients who had a hypervascular primary tumor. Three patients(12.5%) experienced late recurrence; the location of the first recurrence was extrahepatic in 14 patients(58.3%), intrahepatic in 7 patients(29.2%) and both intrahepatic and extrahepatic in 3 patients(12.5%). Two patients had a variation in imaging characteristics between the primary HCC(hypervascular) and the intrahepatic recurrent HCC(hypovascular), while 1 patient had a variation of histopathological characteristics(from moderate to poor differentiation), however no association was found between imaging and histopathological variations.CONCLUSION: A correlation was found between HCC grade and vascularity; some degree of variability may exist between the primary and the recurrence imaging/histopathological characteristics, apparently not correlated. | Annarita Pecchi Giulia Besutti Mario De Santis Cinzia Del Giovane Sofia Nosseir Giuseppe Tarantino Fabrizio Di Benedetto Pietro Torricelli | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 7 | 末次冰消期南大洋深部流通性增强的罗斯海沉积记录显示文摘南大洋因其面积广阔等优势,能够存储更多的热量和二氧化碳(CO_(2)),因此在全球碳循环及气候变化中的地位十分重要。罗斯海作为南大洋第二大边缘海,是研究古海洋演化的理想海域。本研究采用罗斯海陆坡和海盆区的3根插管沉积物岩芯——BC008(水深1063 m,长27 cm,年龄6.0~14.8 ka B.P.)、BC010(水深2055 m,长44 cm,年龄0~15.5 ka B.P.)和BC006(水深2120 m,长54 cm,年龄0~22.3 ka B.P.),通过分析其生物硅含量及浮游有孔虫碳同位素比值(Nps-δ^(13)C)的变化发现,生物硅含量在末次冰消期较高,在约16 ka B.P.达到极大值,这指示了冰消期罗斯海海域深层水上涌增强并在约16 ka B.P.最为剧烈。与此同时,Nps-δ^(13)C的负偏,指示了南大洋上涌的水团将溶解的硅酸盐传递至海洋表层的同时,也将碳同位素等化学信号传递至表层海水。深层水上涌在末次冰消期显著增强的趋势,与大气CO_(2)浓度在冰消期之后的急剧上升十分吻合,这进一步验证了冰消期南大洋深层水上涌的假说及其对大气CO_(2)浓度上升的贡献。此外,本研究进一步讨论了引起末次冰消期南大洋深层水上涌的可能触发机制,主要可能因南北两极热量分布不均,导致南半球西风带位置和强度以及大西洋经向翻转流强度发生变化,进而驱动南大洋深层水上涌。 | 崔超 唐正 M.Rebesco L.De Santis 李朝新 王湘芹 孙书文 刘焱光 | 2021 | 第四纪研究2021，41，3： | 4 |
| 8 | Initial scalar lithospheric magnetic anomaly map of China and surrounding regions derived from CSES satellite data显示文摘The China Seismo-Electromagnetic Satellite(CSES),China’s first satellite to measure geophysical fields with scientific goals in both space and solid earth physics,was launched successfully in February 2018.It carries high-precision magnetometers to measure the geomagnetic field.In this study,the CSES magnetic data were used to extract the signal of the lithospheric magnetic field caused by magnetized rocks in the crust and uppermost mantle.First,an along-track analysis of the CSES magnetic data was undertaken near the Bangui magnetic anomaly in central Africa and the Tarim magnetic anomaly in China,demonstrating that the CSES magnetic data are indeed sensitive to the lithospheric magnetic anomaly field.Then a lithospheric magnetic anomaly map over China and surrounding regions was derived.This map is consistent with the lithospheric part of the CHAOS-7 model.In particular,it clearly reveals four major magnetic anomalies containing long-wavelength signals at the altitude of lowearth-orbiting satellites.Three magnetic highs are located over the Tarim,Sichuan and Songliao basin,the origins of which could be related to large-scale tectonic-magmatic activities during geological history.A prominent magnetic low is otherwise found in the southern Himalayan-Tibetan plateau,possibly caused by the shallow Curie depth in this region.To further improve the precision of the lithospheric magnetic field model,more detailed data processing and multi-source data merging are needed. | WANG Jie SHEN XuHui YANG YanYan ZEREN ZhiMa HULOT Gauthier OLSEN Nils ZHOU Bin MAGNES Werner DE SANTIS Angelo HUANG JianPing GUO Feng LIU WenLong YU JingBo | 2021 | Science China(Technological Sciences)2021，64，5： | 4 |
| 9 | Limit on the production of a light vector gauge boson in ? meson decays with the KLOE detector显示文摘 | D. Babusci D. Badoni I. Balwierz-Pytko G. Bencivenni C. Bini C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl G. Capon F. Ceradini P. Ciambrone E. Czerwiński E. Danè E. De Lucia G. De Robertis A. De Santis A. Di Domenico C. Di Donato R. Di | 2013 | Physics Letters B2013，，： | 4 |
| 10 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 4 |
| 11 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 12 | Structure and Magnetic Properties of Monodisperse Fe^(3+)-doped CeO_2 Nanospheres显示文摘This work reports the study concerning the structure and magnetic properties of undoped CeO_2 and Fe-doped CeO_2(Ce_(1-x) Fe_xO_2, 0.01 ≤ x ≤ 0.07) nanospheres with diameters of 100~200 nm prepared by hydrothermal method using polyvinylpyrrolidone(PVP) as surfactant. The prepared samples were studied by using X-ray diffraction(XRD), Raman spectroscopy, transmission electron microscopy(TEM), high-resolution transmission electron microscopy(HRTEM), X-ray absorption near-edge structure(XANES), and vibrating sample magnetometry(VSM). The XRD results showed that Fe-doped CeO_2 was single-phased with a cubic structure, and with Fe^(3+)successfully substituting in Ce^(4+) sites. Raman spectra showed a redshift of F_(2g) mode that caused by the Fe doping. The samples of both undoped CeO_2 and Fe-doped CeO_2 exhibited room temperature ferromagnetism, and the saturated magnetization(Ms) increased with increasing Fe content until x = 0.05, and then the samples displayed ferromagnetic loops as well as paramagnetic behavior. The roles of Ce^(3+) and Fe^(3+)spin electrons are discussed for the ferromagnetism in the Fe-doped CeO_2. | Sumalin Phokha Supree Pinitsoontorn Santi Maensiri | 2013 | Nano-Micro Letters2013，5，4： | 4 |
| 13 | 3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior显示文摘Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds. | Ugo D'Amora Teresa Russo Antonio Gloria Virginia Rivieccio Vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis | 2017 | Bioactive Materials2017，2，3： | 3 |
| 14 | Myocarditis in athlete and myocardial bridge:An innocent bystander?显示文摘Myocarditis is a bacterial or viral inflammatory disease,often unnoticed or misdiagnosed.Athletes with myocarditis must stop practicing their activity since International medical Literature described some cases of sudden death.In the present report,we describe a case of an asymptomatic,apparently healthy,competitive athletes,who was diagnosed a myocarditis and as incidental finding a myocardial bridging.We focused the attention on the importance of anamnesis,electrocardiogram and athletes' entourage for the diagnosis of such insidious pathologies and we evaluated the follow up,focusing the attention on electrocardiogram changes as well as on restitution ad integrum and prognosis,especially for the athletes. | Federico Quaranta Emanuele Guerra Fabio Sperandii Francesco De Santis Fabio Pigozzi Leonardo Calò Paolo Borrione | 2015 | World Journal of Cardiology2015，7，5： | 3 |
| 15 | Solitary and Multiple Isolated Metastases of Clear Cell Renal Carcinoma to the Pancreas: An Indication for Pancreatic Surgery显示文摘 | Franz Sellner MD Natascha Tykalsky MD Maria Santis MD J?rg Pont MD M. Klimpfinger MD | 2006 | Annals of Surgical Oncology2006，，1： | 3 |
| 16 | Search for light vector boson production in e + e ? → μ + μ ? γ interactions with the KLOE experiment显示文摘 | D. Babusci I. Balwierz-Pytko G. Bencivenni C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl F. Ceradini P. Ciambrone F. Curciarello E. Czerwiński E. Danè V. De Leo E. De Lucia G. De Robertis A. De Santis P. De Simone A. Di Cicco A. Di Dome | 2014 | Physics Letters B2014，，： | 3 |
| 17 | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control显示文摘AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake. | Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo Roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 18 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 19 | Maturity status classification of papaya fruits based on machine learning and transfer learning approach显示文摘Papaya(Carica papaya)is a tropical fruit having commercial importance because of its high nutritive and medicinal value.The packaging of papaya fruit as per its maturity status is an essential task in the fruit industry.The manual grading of papaya fruit based on human visual perception is time-consuming and destructive.The objective of this paper is to suggest a novel non-destructive maturity status classification of papaya fruits.The paper suggested two approaches based on machine learning and transfer learning for classification of papaya maturity status.Also,a comparative analysis is carried out with different methods of machine learning and transfer learning.The experimentation is carried out with 300 papaya fruit sample images which includes 100 of each three maturity stages.The machine learning approach includes three sets of features and three classifiers with their different kernel functions.The features and classifiers used in machine learning approaches are local binary pattern(LBP),histogram of oriented gradients(HOG),Gray Level Cooccurrence Matrix(GLCM)and k-nearest neighbour(KNN),support vector machine(SVM),Naı¨ve Bayes respectively.The transfer learning approach includes seven pretrained models such as ResNet101,ResNet50,ResNet18,VGG19,VGG16,GoogleNet and AlexNet.The weighted KNN with HOG feature outperforms other machine learningbased classification model with 100%of accuracy and 0.0995 s training time.Again,among the transfer learning approach based classification model VGG19 performs better with 100%accuracy and 1 min 52 s training time with consideration of early stop training.The proposed classification method for maturity classification of papaya fruits,i.e.VGG19 based on transfer learning approach achieved 100%accuracy which is 6%more than the existing method. | Santi Kumari Behera Amiya Kumar Rath Prabira Kumar Sethy | 2021 | Information Processing in Agriculture2021，8，2： | 3 |
| 20 | Mechanisms of altered bone remodeling in children with type 1 diabetes显示文摘Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in life.The mechanisms underlying diabetic bone fragility are not yet completely understood.Hyperglycemia and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and microarchitecture.Several factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone turnover.Some myokines may have a key role in regulating metabolic control and improving bone mass in T1DM subjects.The aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM. | Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza | 2021 | World Journal of Diabetes2021，12，7： | 3 |
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