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| 1 | High Frame Rate Contrast-enhanced Ultrasound Helps Differentiate Malignant and Benign Focal Liver Lesions显示文摘Background and Aims:This study aimed to evaluate the diagnostic performance of high frame rate contrast-en-hanced ultrasound(H-CEUS)of focal liver lesions(FLLs).Methods:From July 2017 to June 2019,conventional con-trast-enhanced ultrasound(C-CEUS)and H-CEUS were per-formed in 78 patients with 78 nodules.The characteristics of C-CEUS and H-CEUS in malignant and benign groups and the differences between different lesion sizes(1-3 cm,3-5 cm,or>5 cm)of C-CEUS and H-CEUS were examined.The diagnostic performance of C-CEUS and H-CEUS was ana-lyzed.The chi-square test or Fisher’s exact test was used to assess inter-group differences.The receiver operating characteristic curve was plotted to determine the diagnostic performance of C-CEUS and H-CEUS.Results:There were significant differences in the enhancement area,fill-in direc-tion and vascular architecture between C-CEUS and H-CEUS for both benign and malignant lesions(all p=0.000-0.008),but there were no significant differences in washout results(p=0.566 and p=0.684,respectively).For lesions 1-3 cm in size,the enhancement area,fill-in direction,and vascular architecture on C-CEUS and H-CEUS were significantly dif-ferent(all p=0.000),unlike for lesions 3-5 cm or>5 cm in size.For differentiation of malignant from benign FLLs in the 1-3 cm group,H-CEUS showed sensitivity,specific-ity,accuracy,and positive and negative predictive values of 92.86%,95.0%,96.3%,90.48%and 93.75%,respectively,which were higher than those for C-CEUS(75.0%,70.0%,77.78%,66.67%and 72.91%,respectively).Conclusions:H-CEUS provided more vascular information which could help differentiate malignant from benign FLLs,especially for lesions 1-3 cm in size. | Xiang Fei Peng Han Bo Jiang Lianhua Zhu Wenshuo Tian Maodong Sang Xirui Zhang Yaqiong Zhu Yukun Luo | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 8 |
| 2 | An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean显示文摘A 5.4-kDa 抗真菌的肽与对对 Mycosphaerella arachidicola (IC50= 3 M ) 的 defensins 和禁止的活动高度相应的一个 N 终端序列, Setospaeria turcica 和 Bipolaris maydis,从 Phaseolus vulgaris cv 的种子被孤立。棕色的菜豆。肽被采用必要的一个协议净化 Affi 胶化蓝胶化和单音的 S 上并且最后的吸附 Superdex 75 上的胶化过滤。对 M 的肽的抗真菌的活动。arachidicola 在 pH 范围是稳定的 312 并且在温度范围 0 桴 ?? 整浲湩污搠浯楡獮漠 ? | Yau Sang Chan Jack Ho Wong Evandro Fei Fang Wen Liang Pan Tzi Bun Ng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 6 |
| 3 | A novel monoclinic manganite/multi-walled carbon nanotubes composite as a cathode material of lithium-air batteries显示文摘A novel composite of monoclinic manganite/multi-walled carbon nanotubes(c-MnOOH/MWCNTs)composite as a cathode material of lithium-air batteries was successfully synthesized by a simple one-step hydrothermal method.Owing to the unique three-dimensional network of c-MnOOH embedded in the porous structure of MWCNTs,the c-MnOOH/MWCNTs composite could have an advantage of high electrocatalytic activities over those of two other kinds of cathode materials(MWCNTs and c-MnOOH/MWCNTs mixture).The results of chargedischarge tests showed that the c-MnOOH/MWCNTs composite as a cathode material of lithium-air batteries could effectively enhance the catalytic activity for the oxygen evolution reduction(OER)process.The lithium-air battery based on c-MnOOH/MWCNTs composite exhibits low charge potential and high discharge capacity. | Ming Zhang Qiang Xu Lin Sang Fei Ding Xingjiang Liu | 2014 | Chinese Science Bulletin2014，59，24： | 6 |
| 4 | Intercalibration of international and domestic ^(40)Ar/^(39)Ar dating standards显示文摘Four international standards, Ga1550, MMhb-1, Lp-6, Bern 4M, and one domestic standard BT-1 have been intercalibrated. The repeated measurements on MMhb-1 with different mass demonstrate that MMhb-1 is inhomogeneous in age and its average age is 519.8 Ma. The results of Bern 4M and Lp-6 reflect that they have an invariable value of 40Ar*/39Ark (F) and the ages we obtained are consensus with their K-Ar age: Lp-6=127.7Ma; Bern 4M=18.2 Ma. Analyses of BT-1 age spectra, Ca/K and Cl/K spectra as well as inverse isochrons indicate that the sample is homogeneous and invariable and keeps close chemically, with its trapped argon isotope composition close to the at- mosphere. The dating results show that age values are reproducible and steady, total fusion age, step-heating age, plateau age and isochron age are in accord with each other within the error range (2σ). Therefore, we recommend 28.7 Ma as the calibrated age of BT-1. We also discuss the variation in neutron flux gradients of Beijing 49-2 reactor. It was found that the neutron flux gradient varies considerably, and more monitors (standard samples) are needed to fix the trend of variation. The coefficient of the 49-2 reactor that transfers the ratio of production rate of 37ArCa/39ArK into Ca/K ratio is 1.78. This is different from that reported earlier, 2.0, which may be caused by the reconstruction of the reactor. | WANG Fei HE Huaiyu ZHU Rixiang SANG Haiqing WANG Yinglan YANG Liekun | 2006 | Science China Earth Sciences2006，49，5： | 6 |
| 5 | Laser step-heating ^(40)Ar/^(39)Ar dating on young volcanic rocks显示文摘An attempt was made to use CO_2 laser step-heating method to date the late Pleistocene basaltic groundmass (DF-2) from Tengchong volcanic field. Among the fourteen heating steps, ten define a good inverse isochron (MSWD = 1.4) with an age of 32.2 ± 7.1 ka (2 σ).The inverse isochron also shows that the initial argon isotopic ratio is 297.1±2.0 (2σ) which is the same as the atmospheric argon at the 2σ error level. Study indicates that it is a useful means to date young volcanic groundmass with low K content by using CO_2 laser step-heating ^(40)Ar/^(39)Ar method. | WANG Fei HE Huaiyu ZHU Rixiang YANG Liekun SANG Haiqing WANG Yinglan | 2006 | Chinese Science Bulletin2006，51，23： | 4 |
| 6 | Wormholes propagation for fractured-vuggy formation:Laboratory tests,numerical simulation and field application显示文摘The propagation of wormhole is vital important for matrix acidizing and acid fracturing in carbonate reservoirs.While the formation of acid dissolved wormhole is derived from heterogeneous physical and chemical transportations and reactions.Alveolate dissolved pores,krast caves,and natural fissures are the major reservoir spaces for the Sinian dolomite formation in the Anyue gas field of the Sichuan Basin.There were four categories of formation,which are matrix dominated,inter-breccia dissolved pore dominated,dissolved pore and cave dominated,and fissure and cave dominated,based on the development intensity and connectedness of caves and fissures.The caves and fissures make the wormhole formation and propagation particularly complicated.Firstly,the 3-D topological structure of dissolved pores,vugs,fissures and throats inside cores is quantitatively scanned by CT imaging technology for its feature of vivid and damage-free.Secondly,3-D patterns of wormhole are obtained with CT scanning after core flooding by acid.Additionally,the porethroat network model is reconstructed with digital cores technology.Then,the size and ratio of pore and throat before and after core flooding by acid is analyzed and the absolute permeability of pore scale flow is numerically simulated to understand the fundamental influence of pores and vugs distribution and connectedness on wormhole propagation.Lastly,the wormhole pattern gained by CT scanning and simulating with two-scale model is compared.Meanwhile,the corrected two-scale model is utilized to simulate the wormhole propagation for matrix acidizing and acid fracturing of Sinian fractured-vuggy dolomite in Anyue gas field,Sichuan Basin.The optimized injection rate and volume were in agreement with the characteristic matrix acidizing operating curve,which indicates that the two-scale model was suitable for matrix acidizing optimization design of such formations.In addition,the simulated acid etched fracture length with considering the dynamic wormhole leakoff was consistent with the well testing interpreted result. | Fei Liu Yu Sang Nanxing Xie Li Li Li Ran Weihua Chen | 2017 | Petroleum2017，3，4： | 3 |
| 7 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 8 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 9 | A new long-acting GLP-1 derivative KTP ameliorates hyperglycemia and dyslipidemia and improves pancreas and fatty liver in db/db mice显示文摘Glucagon-like peptide-1 (GLP-1) is a polypeptide incretin hormone that glucose-dependently promotes the secretion and synthesis of insulin. However, its half-life is extremely short. To enhance its half-life, we developed a long-acting GLP-1 derivative KTP with controlled release, designed on the basis of another GLP-1 derivative GP62. The kinetics and bioactivity of KTP were evaluated in Sprague Dawley (SD) rats. Long-term treatment of KTP was performed in db/db mice. Mice were treated twice daily with subcutaneous injections of KTP (1.2 mg/kg body weight), Exendin-4 (0.1 mg/kg body weight) or vehicle (phosphate buffered saline (PBS), pH 7.4) for 60 d. KTP had a longer half-life, as well as further increasing the secretion and production of insulin and reducing blood glucose concentrations, than GP62. Long-term treatment with KTP also induced anorexia, decreased water and food intake, decreased weight gain, improved blood glucose and blood lipid and ameliorated pancreatic damage and fatty liver in db/db mice. | SANG YanXia ZHOU TianHong LI HongJian RAN YanHong JIANG DeQi ZHENG Fei CHEN Ying WANG CongFeng ZOU Xin | 2013 | Chinese Science Bulletin2013，58，20： | 2 |
| 10 | Influence of simulating deep-sea environmental factors on cathodic performance of seawater battery显示文摘A metal-dissolved oxygen seawater battery(SWB)uses metal and dissolved oxygen as the reactants,and it is ideal for use as a long-time low-power distributed power supply in deep sea,due to its advantages of open structure in service without electrolyte.However,several simulating deep-sea environmental factors,such as flow rate,dissolved oxygen concentration,and temperature of seawater may af fect the oxygen reduction reaction(ORR)rate and the stability of electrochemically modified polyacrylonitrile-based carbon fiber brush(MPAN-CFB)cathode,which was studied by steady-state polarization and galvanostatic discharge methods.In addition,the scales formed on MPAN-CFB surface were characterized by SEM and XRD.Results show that the ORR rate increased quickly with the increase of the seawater flow rate up to 3 cm/s,and then gradually stabilized.Moreover,the ORR rate was largely af fected by dissolved oxygen concentration,and the concentration of>3 mg/L was favorable.Compared with surface layer temperature of 15℃,the low temperature of deep sea(4℃)has a negligible ef fect on ORR rate.When the working current is too high,it will lead to the formation of CaCO_3 scales(aragonite)of at the cathodic surface,resulting in the decrease of ORR rate,and consequently the damage to the long-time stability of MPAN-CFB. | LU Yonghong YANG Lulu ZHANG Yue ZHAO Qing SANG Lin DING Fei XU Haibo | 2020 | Journal of Oceanology and Limnology2020，38，2： | 2 |
| 11 | Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia显示文摘 | Wen Liang Pan Jack Ho Wong Evandro Fei Fang Yau Sang Chan Tzi Bun Ng Randy Chi Fai Cheung | 2014 | Biochemical Pharmacology2014，，： | 1 |
| 12 | Coordination Degree of Urban Population, Economy, Space, and Environment in Shenyang Since 1990显示文摘 | Zhang Pingyu Su Fei Li He Sang Qiu | 2008 | China Population, Resources and Environment2008，，2： | 1 |
| 13 | BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis显示文摘As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this effect is reversible. However, the mechanism of JQ1 acting on gene regulation in spermatogenesis remains unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) on mouse testes treated with JQ1 or vehicle control to determine the transcriptional regulatory function of JQ1 in spermatogenesis at the single cell resolution. We confirmed that JQ1 treatment could increase the numbers of somatic cells and spermatocytes and decrease the numbers of spermatid cells. Gene Ontology (GO) analysis demonstrated that differentially expressed genes which were down-regulated after JQ1 injection were mainly enriched in “DNA conformation change” biological process in early developmental germ cells and “spermatid development” biological process in spermatid cells. ATAC-seq data further confirmed that JQ1 injection could change the open state of chromatin. In addition, JQ1 could change the numbers of accessible meiotic DNA double-stranded break sites and the types of transcription factor motif that functioned in pachytene spermatocytes and round spermatids. The multi-omics analysis revealed that JQ1 had the ability to regulate gene transcription by changing chromatin conformation in mouse spermatogenesis, which would potentiate the availability of JQ1 in male contraceptive. | Xiaorong Wang Mengmeng Sang Shengnan Gong Zhichuan Chen Xi Zhao Guishuan Wang Zhiran Li Yingying Huang Shitao Chen Gangcai Xie Enkui Duan Fei Sun | 2022 | Genes & Diseases2022，9，4： | 1 |
| 14 | Gene expression during seed maturation in Brassica napus in relation to the induction of secondary dormancy显示文摘 | Fei H T sang E Cutler A J | | 0，，： | 1 |
| 15 | Extended culture of day 3 embryos improves live birth rate in in vitro fertilization-embryo transfer显示文摘To the Editor:Embryo development at the early cleavage stage is a complex and well-orchestrated biological process.During in vitro fertilization-embryo transfer(IVF-ET),embryos are routinely stratified according to morphological criteria and transferred on the morning of day 3 after fertilization.This stage of embryonic development is mainly regulated by maternal factors because the embryonic genome has not yet been fully activated.[1]Day 3 is a key period for embryos to accomplish embryonic genome activation(EGA).Embryos with higher developmental potential initiate EGA for subsequent development and implantation,while non-viable embryos undergo arrest. | Shao-Kang MoYuan-Kun Sang Xiao-Peng Zhao Ling Wang Lu Ma Di Zuo Fei Chang Li-Yuan Zhang Jun-Long Jia Shao-Kang Mo Yuan-Kun Sang Bin-Bin Ma Fang Xu | 2020 | Chinese Medical Journal2020，，14： | 1 |
| 16 | Population transcriptomics reveals a potentially positive role of expression diversity in adaptation显示文摘While it is widely accepted that genetic diversity determines the potential of adaptation,the role that gene expression variation plays in adaptation remains poorly known.Here we show that gene expression diversity could have played a positive role in the adaptation of Miscanthus lutarioriparius.RNA-seq was conducted for 80 individuals of the species,with half planted in the energy crop domestication site and the other half planted in the control site near native habitats.A leaf reference transcriptome consisting of 18,503 high-quality transcripts was obtained using a pipeline developed for de novo assembling with population RNA-seq data.The population structure and genetic diversity of M.lutarioriparius were estimated based on 30,609 genic single nucleotide polymorphisms.Population expression(Ep) and expression diversity(Ed)were defined to measure the average level and the magnitude of variation of a gene expression in the population,respectively.It was found that expression diversity increased while genetic Resediversity decreased after the species was transplanted from the native habitats to the harsh domestication site,especially for genes involved in abiotic stress resistance,histone methylation,and biomass synthesis under water limitation.The increased expression diversity could have enriched phenotypic variation directly subject to selections in the new environment. | Qin Xu Shilai Xing Caiyun Zhu Wei Liu Yangyang Fan Qian Wang Zhihong Song Wenhui Yang Fan Luo Fei Shang Lifang Kang Wenli Chen Juan Yan Jianqiang Li Tao Sang | 2015 | Journal of Integrative Plant Biology2015，57，3： | 1 |
| 17 | Correlat ion of thiamine metabolite levels with cognitive function in the non-demented elderly显示文摘Thiamine metabolism is critical for glucose metabolism and also vital for brain function,which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers >60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination(MMSE) scores were measured. The apolipoprotein E(APOE) genotype,routine blood parameters,liver and kidney function,and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate(TDP) level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE ε2 allele,body mass index,hemoglobin level,fasting blood glucose,and triglycerides. Our results suggest that TDP,which is easily affected by many factors,impacts cognitive function in the elderly. | Jingwen Lu Xiaoli Pan Guoqiang Fei Changpeng Wang Lei Zhao Shaoming Sang Huimin Liu Meng Liu Hui Wang Zhiliang Wang Chunjiu Zhong | 2015 | Neuroscience Bulletin2015，31，6： | 1 |
| 18 | Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro显示文摘Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested.Here,wereport thatmousehaESCs can differentiate in vitro into haploid epiblast stem cells(haEpiSCs),which maintain an intact haploid genome,unlimited self-renewal potential,and durable pluripotency to differentiate into various tissues in vitro and in vivo.Mechanistically,the maintenance of self-renewal potential depends on the Activin/bFGF pathway.We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.When injected into the cytoplasm of an oocyte,androgenetic haEpiSC(ahaEpiSCs)can support embryonic development until midgestation(E12.5).Together,these resultsdemonstrate durable pluripotency inmousehaESCs andhaEpiSCs,aswell asthe valuable potential of using these haploid pluripotent stem cells in high-throughput genetic screening. | Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2015 | Journal of Molecular Cell Biology2015，7，4： | 1 |
| 19 | Gene expression profile in chronic mouse liver injury caused by long-term exposure to CeCl3显示文摘 | CHENG J FEI M SANG X | 2014 | Environ Toxicol2014，29，7： | 1 |
| 20 | Trends of Lower- to Mid-Stratospheric Water Vapor Simulated in Chemistry-Climate Models显示文摘Using the outputs from 16 chemistry-climate models(CCMs), the trends of lower- to mid-stratospheric water vapor(WV) during the period 1980–2005 were studied. Comparisons were made between the CCM results and European Centre for Medium-Range Weather Forecasts(ECMWF) Interim Reanalysis(ERA-Interim).The results of most of the CCMs, and those based on ERA-Interim, showed the trends of lower- to mid-stratospheric WV during the period 1980–2005 to be positive, with the extent of the trend increasing with altitude. The trend of lower- to mid-stratospheric WV in the ensemble mean of the CCMs was 0.03 ppmv per decade,which was about twice as large as that based on ERA-Interim. The authors also used a state-of-the-art general circulation model to evaluate the impacts of greenhouse gas(GHG) concentration increases and ozone depletion on stratospheric WV. The simulation results showed that the increases of lower- to mid-stratospheric WV affected by the combined effects of GHG and ozone changes happened mainly via warming of the tropopause and enhancement of the Brewer-Dobson circulation(BDC), with the former being the greater contributor.GHG increase led to a higher and warmer tropopause with stronger BDC, which in turn led to more WV entering the stratosphere; while ozone depletion led to a higher and cooler tropopause, which caused the decreases of lowerto mid-stratospheric WV, despite also causing stronger BDC. | HU Ding-Zhu HAN Yuan-Yuan SANG Wen-Jun XIE Fei | 2015 | Atmospheric and Oceanic Science Letters2015，8，1： | 0 |
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