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| 1 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Cell attachment and oxygen consumption of two strains of thiobacillus ferrooxidans显示文摘 | Blake Ⅱ R C | 1999 | Minerals Engineering1999，12，6： | 1 |
| 4 | Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels 显示文摘 | Sampson L J Davies L M Barrett-Jolley R | 2007 | Cardiovasc Res2007，76，1： | 1 |
| 5 | The di aphragm : two muscles显示文摘 | Troyer AD Sampson M Sigrist S | 1981 | Science1981，，： | 1 |
| 6 | The transcriptional reprcssor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation显示文摘 | Xiu M Kim J Sampson E | 2003 | Mol Call Biol2003，23，23： | 1 |
| 7 | Formal contracts in the presence of relational enforcement mechanisms: evi- dence from technology development projects显示文摘 | Ryall M D Sampson R C | 2009 | Man- agement Science2009，55，6： | 1 |
| 8 | Twelve- month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States显示文摘 | Kessler RC Petukhova M Sampson NA | 2012 | Int J Methods Psychiatr Res2012，21，3： | 1 |
| 9 | Influence of the attachment of acidophilic bacteria during the oxidation of mineral sulfides显示文摘 | Phillips C V Blake Ⅱ R C | 2000 | Minerals Engineering2000，13，4： | 1 |
| 10 | Action of costal and crural parts of the diaphragm on the rib cage in dog显示文摘 | De Troyer A Sampson M Sigrist S | 1982 | J Appl Physiol1982，53，1： | 1 |
| 11 | Measurement of the clinical and cost-effectiveness of non-invasive diagnostic testing strategies for deep vein thrombosis 显示文摘 | Goodacre S Sampson F Stevenson M | 2006 | Health Technol Assess2006，10，15： | 1 |
| 12 | An operational statisti- cal typhoon intensity prediction scheme for the western north paeifie显示文摘 | Knaff J A Sampson C R DeMaria M | 2005 | Wea Forecasting2005，20，： | 1 |
| 13 | Customer Roles in Service Supply Chains and Opportunities for Innovation显示文摘 | SAMPSON S E SPRING M | 2012 | Journal of Supply Chain Management2012，48，4： | 1 |
| 14 | Lithium Determinations Evaluated in Eight Analyzers 显示文摘 | Sampson M Ruddel M Ronald J | 1994 | Clin Chem1994，40，6： | 1 |
| 15 | Cast electrical insulation quality enhancements through improved filler technology显示文摘 | Paul M Sampson | 2001 | IEEE Electrical Insulation Magazine2001，17，5： | 1 |
| 16 | Presenting features of breast cancer differ by molecular subtype显示文摘 | Wiechmann L Sampson M Stempel M | 2009 | Ann Surg Oncol2009，16，10： | 1 |
| 17 | A review of optical coherence elastography: fundamentals, techniques and prospects显示文摘 | Kennedy B F Kennedy K M Sampson D D | 2014 | IEEE J Sel Top Quantum Electron2014，20，71： | 1 |
| 18 | Immunomodulatory effect of the anti-asthma Chinese herbal formula,MSSM-002 on Th2 cells显示文摘 | Srivastava K Teper AA Zhang TF Li S Walsh MJ Huang CK Kattan M Schofield BH Sampson HA Li XM | | 0，，02： | 1 |
| 19 | Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tu- berculosis demonstrates genome plasticity显示文摘 | Warren RM Sampson SL Richardson M | 2000 | Mol Microbiol2000，37，6： | 1 |
| 20 | Prediction of dental arch development: an assessment of Pont′s index in three human populations显示文摘 | Dalidjan M Sampson W Townsend G | 1995 | Am J Orthod Dentofacial Orthop1995，107，5： | 1 |
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