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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | The impact of NHS Di rect on the demand for out-of-hours primary and emer- gency care显示文摘 | Munro J Sampson F Nicholl J | 2005 | Br J Gen Pract2005，55，519： | 1 |
| 3 | Measurement of the clinical and cost-effectiveness of non-invasive diagnostic testing strategies for deep vein thrombosis 显示文摘 | Goodacre S Sampson F Stevenson M | 2006 | Health Technol Assess2006，10，15： | 1 |
| 4 | Comparison of leaf area index estimates from tree allometrics and measured light interception显示文摘 | Smith F W Sampson D A Long J N | 1991 | Forest Science1991，37，6： | 1 |
| 5 | A review of optical coherence elastography: fundamentals, techniques and prospects显示文摘 | Kennedy B F Kennedy K M Sampson D D | 2014 | IEEE J Sel Top Quantum Electron2014，20，71： | 1 |
| 6 | Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease显示文摘 | Sampson U K Dorbala S Limaye A Kwong R Di Carli M F | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 7 | Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis显示文摘 | Goodacre S Sampson F Thomas S | 2005 | BMC Med Imaging2005，5，： | 1 |
| 8 | Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity显示文摘 | KOTEWICZ M L SAMPSON C M DALESSIO J M GERARD G F | 1988 | Nucleic Acids Res1988，16，1： | 1 |
| 9 | Structured three-dimensional optical phantom for optical coherence tomography 显示文摘 | Curatolo Andrea Kennedy Brendan F Sampson David D | 2011 | Optics Express(S1094-4087)2011，19，19： | 1 |
| 10 | Neighborhoods and violent Grime:a multilevel study of collective efficacy显示文摘 | SAMPSON R J RAUDENBUSH S W EARLS F | 1997 | Science1997，，277： | 1 |
| 11 | Measurement of the clinl- cal and cost - effectiveness of non - invasive diagnostic testing strategies for deep vein thrombosis 显示文摘 | Goodacre S Sampson F Stevenson M | 2006 | Health Technol Assess2006，10，15： | 1 |
| 12 | Systematic review and recta-analysis of the diagnostic of ultrasonography for deep vein thrombosis显示文摘 | Goodacre S Sampson F Thomad S etal | 2005 | BMC Med Imaging2005，3，5： | 1 |
| 13 | Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis显示文摘 | Goodacre S Sampson F Thomas S | | 0，，： | 1 |
| 14 | Global and Regional Burden of Aortic Dissection and Aneurysms:Mortality Trends in 21 World Regions,1990 to 2010显示文摘 | Sampson U K A Norman P E Fowkes F G R | 2014 | Global Heart2014，9，1： | 1 |
| 15 | Systematic review and meta-analysis of the diagnostic accuracy of uhrasonography for deep vein thrombosis 显示文摘 | Goodacre S Sampson F Thomas S | 2005 | BMC Med Imaging2005，5，： | 1 |
| 16 | Systematic review and meta-analysis of the diagnosis accuracy of ultrasonography foe deep vein thrombosis显示文摘 | Goodacre S Sampson F Thomas S | | 0，，： | 1 |
| 17 | Application of stepwise regression to nonlinear estimation显示文摘 | JENNRICH R I SAMPSON P F | 1968 | Technometrtcs1968，10，： | 1 |
| 18 | The value of clinical features in the diagnosis of acute pulmonary embolism : systematic review and meta - analysis显示文摘 | West J Goodacre S Sampson F | 2007 | Q J Med2007，100，12： | 1 |
| 19 | Effect of various levels of alfalfa meal on development of body organs of cockerels显示文摘 | Sampson F R Mussehl F E | 1936 | Poultry Science1936，15，： | 1 |
| 20 | Radiofrequencyversus microwave ablation in a hepatic porcine model显示文摘 | Wright A S Sampson L A Warner T F | 2005 | Radi-ology2005，236，： | 1 |
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