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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014,20,7: | 5 |
| 2 | A computer program for monitoring and controlling ultrasonic anemome- ters for aerodynamic measurements in animal buildings 显示文摘 | Samer M Loebsin C Bobrutzki K Von | 2011 | Computers and Electronics in Agriculture2011,79,: | 1 |
| 3 | Compositional and material properties of rat bone after bisphosphonate and/or Strontium ranelate drug treatment显示文摘 | WU Yuchin SAMER M DUKE M | 2013 | Journal of pharmacy and pharmaceutical sciences2013,16,1: | 1 |
| 4 | Right ventriculer dysfunction in patients with obstructive sleep apnea syndrome显示文摘 | Samer BM Konermann M Sturm A | 1997 | Eur Respir J1997,10,9: | 1 |
| 5 | Evaluation of E-learning program versus traditional lecture instruction for undergraduate nursing students in a faculty of nursing显示文摘 | Abdelaziz M Samer Kamel S Karam O | 2011 | Teaching and Learning in Nursing2011,6,2: | 1 |
| 6 | Monte Carlo simulation of rock slope reliability显示文摘 | TAMIMI SAMER AMADEI Bernard FRANGOPOL Dan M | 1989 | Computers & Structures1989,33,6: | 1 |
| 7 | Development of a pavement rutting model from experimental data显示文摘 | ADRIAN R A SAMER M | 2000 | Journal of Transportation Engineering(ASCE)2000,126,4: | 1 |
| 8 | A case for further investigating the use of controlled lumbar cerebrospinal fluid drainage for the control of intracranial pressure显示文摘 | Ali M Samer G Austin RT | | 0,,01: | 1 |
| 9 | Learning control algorithms for tracking slowly varying trajectories显示文摘 | Samer W G V Saab S Mickle M H | 1997 | IEEE Trans Syst Man Cybern B1997,27,3: | 1 |
| 10 | 关于平面超冗余度机械手逆运动轨迹和工作空间图形化研究显示文摘 | Samer Yahya M Moghavvemi Haider A F. Mohamed | 2011 | 仿真模拟实践与理论2011,,01: | 1 |
| 11 | Hasan want is new in shoulder and elbowsurgery 显示文摘 | Gary M Gartsman Samer S | 2005 | JBJS2005,87,: | 1 |
| 12 | Alkaline earth complexes of 1,4,7,10-tetrakis(2-hydroxycthyl)-and 1,4,7,10-tetrakis(2-methoxyethyl)-1,4,7,10-tetraazacyclododecane;an equilibrium and kinetic study显示文摘 | Ramesh D Stephen F L Samer M | 2000 | Inorg Chem2000,39,: | 1 |
| 13 | Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals显示文摘 | Snyder S A Samer A Redding A M | | 0,,1: | 1 |
| 14 | Overview of therapies for prevention of restenosis after coronary interventions显示文摘 | Samer M G Philip Huber Neal A S | 2001 | Pharmacol Therapeut2001,92,: | 1 |
| 15 | Spectroscopic and HPLC methods for the determination of alendronate in tablets and urine 显示文摘 | SAMI K A IMAD I H SAMER M A | 2004 | Talanta2004,64,3: | 1 |
| 16 | Clinical characteristics of sevoflurane in children : a comparison with halothane 显示文摘 | Samer JB Levine M Dais PJ | 1995 | Anesthesiology1995,82,: | 1 |
| 17 | Elevated aortic pulse wave velocity, a marker of arterial stiffness, Predicts cardiovascular events in well-functioning older adults 显示文摘 | Kim Sutton T Samer S Najjar Robert M | 2005 | Circulation2005,111,6: | 1 |
| 18 | Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Fatty Rat显示文摘 | Samer M Neal MD Basil DR | 2006 | J Pharm Pharmaceut Sci2006,9,3: | 1 |
| 19 | Phytopreventative Anti-Hyperlipidemic Effects Of Gynostemma Pentaphyllum In Rats显示文摘 | Samer M Fugen A Neal MD | 2005 | J Pharm Pharmaceut Sci2005,8,3: | 1 |
| 20 | Gaussian Networks Fordirect Adaptive Control显示文摘 | Samer R M Slotine J J E | 1992 | IEEE Transactions on Neural Network1992,2,6: | 1 |