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| 1 | Targeting inflammation in diabetes: Newer therapeutic options显示文摘Inflammation has been recognised to both decrease beta cell insulin secretion and increase insulin resis-tance. Circulating cytokines can affect beta cell function directly leading to secretory dysfunction and increased apoptosis. These cytokines can also indirectly affect beta cell function by increasing adipocyte inflamma-tion.The resulting glucotoxicity and lipotoxicity further enhance the inflammatory process resulting in a vicious cycle. Weight reduction and drugs such as metformin have been shown to decrease the levels of C-Reactive Protein by 31% and 13%, respectively. Pioglitazone, insulin and statins have anti-inflammatory effects. In-terleukin 1 and tumor necrosis factor-α antagonists are in trials and NSAIDs such as salsalate have shown an improvement in insulin sensitivity. Inhibition of 12-lipo-oxygenase, histone de-acetylases, and activation of sirtuin-1 are upcoming molecular targets to reduce in-flammation. These therapies have also been shown to decrease the conversion of pre-diabetes state to diabe-tes. Drugs like glicazide, troglitazone, N-acetylcysteine and selective COX-2 inhibitors have shown benefit in diabetic neuropathy by decreasing inflammatory mark-ers. Retinopathy drugs are used to target vascular en-dothelial growth factor, angiopoietin-2, various protein-ases and chemokines. Drugs targeting the proteinases and various chemokines are pentoxifylline, inhibitors of nuclear factor-kappa B and mammalian target of rapa-mycin and are in clinical trials for diabetic nephropathy. Commonly used drugs such as insulin, metformin, per-oxisome proliferator-activated receptors, glucagon like peptide-1 agonists and dipeptidyl peptidase-4 inhibitors also decrease inflammation. Anti-inflammatory thera-pies represent a potential approach for the therapy of diabetes and its complications. | Neeraj Kumar Agrawal Saket Kant | 2014 | World Journal of Diabetes2014，5，5： | 41 |
| 2 | Developmental dysplasia of the hip in the newborn: A systematic review显示文摘Developmental dysplasia of the hip(DDH) denotes a wide spectrum of conditions ranging from subtle acetabular dysplasia to irreducible hip dislocations. Clinical diagnostic tests complement ultrasound imaging in allowing diagnosis, classification and monitoring of this condition. Classification systems relate to the alpha and beta angles in addition to the dynamic coverage index(DCI). Screening programmes for DDH show considerable geographic variation; certain risk factors have been identified which necessitate ultrasound assessment of the newborn. The treatment of DDH has undergone significant evolution, but the current gold standard is still the Pavlik harness. Duration of Pavlik harness treatment has been reported to range from 3 to 9.3 mo. The beta angle, DCI and the superior/lateral femoral head displacement can be assessed via ultrasound to estimate the likelihood of success. Success rates of between 7% and 99% have been reported when using the harness to treat DDH. Avascular necrosis remains the most devastating complication of harness usage with a reported rate of between 0% and 28%. Alternative non-surgical treatment methods used for DDH include devices proposed by LeD amany, Frejka, Lorenz and Ortolani. The Rosen splint and Wagner stocking have also been used for DDH treatment. Surgical treatment for DDH comprises open reduction alongside a combination of femoral or pelvic osteotomies. Femoral osteotomies are carried out in cases of excessive anteversion or valgus deformity of the femoral neck. The two principal pelvic osteotomies most commonly performed are the Salter osteotomy and Pemberton acetabuloplasty. Serious surgical complications include epiphyseal damage, sciatic nerve damage and femoral neck fracture. | Vivek Gulati Kelechi Eseonu Junaid Sayani Nizar Ismail Chika Uzoigwe Muhammed Zaki Choudhury Pooja Gulati Adeel Aqil Saket Tibrewal | 2013 | World Journal of Orthopedics2013，4，2： | 29 |
| 3 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 4 | Investigation of structural,magnetic and optical properties of rare earth substituted bismuth ferrite显示文摘Polycrystalline BiFeO3 and rare earth substituted Bi0.9R0.1FeO3(BRFO,R=Y,Ho and Er) compounds were prepared by rapid solid state sintering technique.Structural phase analysis indicated that all the compounds stabilized in rhombohedral structure(R3c space group) and a small orthorhombic phase fraction was observed in BRFO compounds.From the Raman spectra results,the changes in the phonon frequencies(A 1) and line widths suggested lattice distortion in the BRFO compounds as was evidenced in the XRD analysis.Compared to the linear variation of magnetization with magnetic field(M-H) shown by BFO,an obvious M-H loop was observed in BRFO compounds which could be due to the suppression of space modulated spin structure and was explained on the basis of weak ferromagnetism and field induced spin reorientation.UV-Vis spectroscopy evidenced a change in local FeO6 environment due to shift in the 6A1g → 4T2g energy transition band.BRFO compounds with improved remnant magnetization and coercive field are applicable for magnetoelectric devices. | T.Durga Rao T.Karthik Saket Asthana | 2013 | Journal of Rare Earths2013，31，4： | 8 |
| 5 | Influence of A-site cation disorder on structural and magnetocaloric properties of Nd_(0.7–x)La_xSr_(0.3)MnO_3(x=0.0, 0.1, 0.2 & 0.3)显示文摘In the present research, the influence of A-site ionic size disorder on structural, magnetic and magnetocaloric properties of Nd0.7–xLaxSr0.3MnO3(for x=0.0, 0.1, 0.2 & 0.3) compounds were investigated. These compounds were synthesized by solid state reaction route and crystallized in orthorhombic structure with Pnma space group. An average ionic radius increased with La-substitution which influenced the physical properties such as the magnetic entropy varying from 4.78 J/kg·K(for x=0.0) to 3.55 J/kg·K(for x=0.3) and the maximum magnetization at 5 K changing from 3.92 μB(for x=0.0) to 3.59 μB(for x=0.3). The change in maximum magnetic entropy decreased with increase of A-site average ionic radius. The decrease in magnetic entropy indicated the suppression of lattice disorder that influenced the spin-lattice coupling. The ferromagnetic transition temperature shifted toward room temperature with La substitution. As increased, the phase transition changed from first order(for x=0.0) to second order(for x≥ 0.1) and the refrigeration capacity increased to a significant level. The modest change in magnetic entropy over a wide range of transition temperature might be useful for future active magnetic refrigeration technology. | Sudharshan Vadnala Prem Pal Saket Asthana | 2015 | Journal of Rare Earths2015，33，10： | 3 |
| 6 | Antimicrobial peptides versus parasitic infections显示文摘 | Vizioli J saket M | 2002 | Trends parasitol2002，18，11： | 1 |
| 7 | Probabilistic modeling of QCA circuits using Bayesian networks显示文摘 | BHANJA S SAKET S | 2006 | IEEE Transactions on Nanotechnology2006，5，6： | 1 |
| 8 | Retroperitoneal Lymphangioma in an Adult: A Case Report of a Rare Clinical Entity显示文摘 | Mayank Tripathi Sanjeev Parshad Rajender Kumar Karwasra Ashish Gupta Saket Srivastva Ankush Sarwal Gabriel Sandblom | 2015 | Case Reports in Surgery2015，，： | 1 |
| 9 | Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing显示文摘 | S.K. Sharma Saket Kumpawat Ashish Goel Amit Banga Lakshmi Ramakrishnan Pradeep Chaturvedi | 2006 | Sleep Medicine2006，，1： | 1 |
| 10 | Studyonadvancedsupercriticalfluidtechnology显示文摘 | SAKET | 1994 | ProcessTechnolProc1994，11，： | 1 |
| 11 | A bioequivalence study of two dipyridamole products显示文摘 | Arafat T Saket M Awad R | 1989 | Int J Clin pharmacol Ter Toxicol1989，27，： | 1 |
| 12 | CT and MRI findings of sphenoid sinus internal carotid artery pseudoaneurysm:an important and challenging differential diagnosis for a skull base mass显示文摘 | SAKET R R HETTS S W TATUM J K | 2012 | Clin Radiol2012，67，： | 1 |
| 13 | Hepatitis B virus genotypes in chronic liver disease patients from New Delhi,India显示文摘AIM: To study the Hepatitis B virus (HBV) genotypes and their effect on the progression and outcome in patients with chronic liver diseases from New Delhi, India. METHODS: Sera from 100 HBV-related chronic liver disease (CLDB) cases were tested for HBV genotype using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Type-specific primers-based PCR (TSP-PCR) targeting to the surface (S) gene encoding hepatitis B surface antigen. RESULTS: Only genotypes A and D were present and genotype D was dominant. Genotype D was present in all CLDB patient categories. The genotype distribution for the 100 patients with CLDB was as follows: genotype A, 16/100 (16%) (7/40- 17% chronic hepatitis B (CHB); 8/47, 17%, HBV-related cirrhosis (CRB); 1/13, 7.6%, HBV-related hepatocellular carcinoma (HCCB); genotype D- 84/100 (84%) (32/40- 80% CHB; 38/47- 81%, CRB; 11/13, 85%, HCCB); genotype A + D, 3/100 (3%) (1/40- 3% CHB; 1/47- 2%, CRB; 1/13, 7.6%, HCCB); C, 0; B, 0; E, 0; F, 0; G 0, H 0; (P < 0.01, genotype D vs A). CONCLUSION: Only HBV genotypes A and D were present in patients with CLDB from New Delhi, India. Compared with genotype D, genotype A patients had no significant clinical or biochemical differences (P > 0.05). Mixed infection with genotype A and D were seen in 3% of the cases. Genotype D was the dominant genotype prevalent in all patient categories. | Saket Chattopadhyay Bhudev Chandra Das Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，41： | 1 |
| 14 | Novel intravascular ultrasound-guided method to create transintimal arterial communication: initial experience in peripheral occlusive disease and aortic dissection 显示文摘 | Saket RR Razavi MK Padidar A | 2004 | J Endovasc Ther2004，11，3： | 1 |
| 15 | CTand MRI findings of sphenoid sinus internal carotid artery pseudoaneurysm:an important and challenging differential diagnosis for a skull base mass显示文摘 | SAKET R R HETTS S W TATUM J K | 2012 | Clin Radiol2012，67，： | 1 |
| 16 | Stent-graft treatment of extracranial carotid and vertebral arterial lesions显示文摘 | Saket RR Razavi MK Sze DY | 2004 | J Vasc Interv Radiol2004，15，： | 1 |
| 17 | Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum显示文摘 | Subash Chandra Mohapatra Hemandra Kumar Tiwari Manisha Singla Brijesh Rathi Arun Sharma Kuldeep Mahiya Mukesh Kumar Saket Sinha Shyam Singh Chauhan | 2010 | JBIC Journal of Biological Inorganic Chemistry2010，，3： | 1 |
| 18 | Semi-supervised ker- nel mean shift clustering 显示文摘 | Saket A Sushil M Once1 T Peter M | 2014 | IEEE Transactions on Pattern Analysis and Machine Intelligence2014，36，6： | 1 |
| 19 | A bioequiv- alence study of two dipyridamole products 显示文摘 | ARAFAT T SAKET M AWAD R | 1989 | Int J Clin pharmacol Ter Toxicol1989，27，： | 1 |
| 20 | Prevalence and Risk Factors of Obstructive Sleep Apnea Syndrome in a Population of Delhi, In- dia显示文摘 | Surendra KS Saket K Amit B | 2006 | Chest2006，130，1： | 1 |
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