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| 1 | The potential applications of cone beam computed tomography in the management of endodontic problems显示文摘 | S.Patel A.Dawood T. PittFord E.Whaites | 2007 | International Endodontic Journal2007，，10： | 2 |
| 2 | A comparison of proxy measures of abdominal obesity in Chinese, European and South Asian adults显示文摘 | S.Patel N.Unwin R.Bhopal M.White J.Harland S. A. M.Ayis W.Watson K. G. M. M.Alberti | 2001 | Diabetic Medicine2001，，： | 1 |
| 3 | Intrahepatic flow diversion prior to segmental Yttrium-90 radioembolization for challenging tumor vasculature显示文摘Background: Hepatic tumors with complex vascular supply or poor relative perfusion are prone to decreased rates of objective response. This is compounded in the setting of Yttrium-90(Y90) transarterial radioembolization(TARE), which is minimally embolic and flow-dependent, relying on high threshold dose for complete response.Objective: We describe our experience with intrahepatic flow diversion(FD) prior to TARE of hepatocellular carcinoma(HCC) with challenging vascular supply.Materials and methods: Between April 2014 and January 2020, 886 cases of coinciding MAA or TARE and bland embolization or temporary occlusion were identified.Intraprocedural embolizations performed for more routine purposes were excluded. FD was performed by bland embolization or temporary occlusion of vessels supplying non-malignant parenchyma in cases where flow was not preferential to target tumor. Lesion characteristics, vascular supply, treatment approach, angiography, and adverse events(AEs) were reviewed. Radiographic response was assessed using mRECIST criteria.Results: 22 cases of FD of focal HCC were identified. Embolics included calibrated microspheres(n = 11), microcoils(n = 4), gelfoam(n = 3), temporary balloon occlusion(n = 2) and temporary deployment of a microvascular plug(n = 1). Post-treatment SPECT-CT dosimetry coverage was concordant with target lesions in all cases. Mean follow-up was 16.7 months(1.4–45 mos). Tumor-specific response per m RECIST was 41% complete response, 50% objective response, and 59% disease control rate. No major adverse events or grade 3/4 hepatotoxicity were reported.Conclusion: Our findings suggest that FD prior to TARE is safe and potentially effective in treating HCC with complex vascular supply or poor tumor perfusion. | Lindsay B.Young Marcin Kolber Michael J.King Mona Ranade Vivian L.Bishay Rahul S.Patel Francis S.Nowakowski Aaron M.Fischman Robert A.Lookstein Edward Kim | 2022 | Journal of Interventional Medicine2022，5，2： | 1 |
| 4 | ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network显示文摘 | WallaceCrandall Michael D.Kappelman Richard B.Colletti IanLeibowitz John E.Grunow SabinaAli Howard I.Baron James H.Berman BrendanBoyle StanleyCohen Fernandodel Rosario Lee A.Denson LynnDuffy Mark J.Integlia Sandra C.Kim DavidMilov Ashish S.Patel Bess T.Sc | 2010 | Inflamm Bowel Dis2010，，1： | 1 |
| 5 | Short pediatric Crohn’s disease activity index for quality improvement and observational research显示文摘 | Michael D.Kappelman Wallace V.Crandall Richard B.Colletti AnthonyGoudie Ian H.Leibowitz LynnDuffy David E.Milov Sandra C.Kim Bess T.Schoen Ashish S.Patel JohnGrunow EvetteLarry GerryFairbrother PeterMargolis | 2010 | Inflamm Bowel Dis2010，，1： | 1 |
| 6 | LC-MS/MS assay for olanzapine in human plasma and its application to a bioequivalence study显示文摘This paper describes a selective and sensitive assay for the determination of olanzapine(OLZ)in human plasma based on liquid chromatography-tandem mass spectrometry(LC-MS/MS).The analyte and quetiapine as internal standard(IS)were extracted from 200μL plasma via solid phase extraction on Waters Oasis HLB cartridges.Chromatographic separation was achieved on an ACE 5C18-300 column(100 mm × 4.6 mm,5μm)under isocratic conditions in a run time of 3.5 min.Mass spectrometric detection involved electrospray ionization in the positive ion mode followed by multiple reaction monitoring(MRM)of the transitions at m/z 313/256 for OLZ and m/z 384/253 for the IS.The assay was linear in the range 0.10-40.0 ng/mL with a lower limit of quantitation and limit of detection of 0.10 and 0.012 ng/mL,respectively.Intra-and inter-day precision(as coefficient of variation)and relative recovery were<5.0% and>90%,respectively.The method was succesfully applied to a bioequivalence study of 5 and 10 mg OLZ disintegrating tablets in 40 healthy Indian males with reproducibility by incurred sample reanalysis in the range-7.43 to 8.07%. | Dinesh S.Patel Naveen Sharma Mukesh C.Patel Bhavin N.Patel Pranav S.Shrivastav Mallika Sanyal | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 1 |
| 7 | Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS显示文摘A highly selective and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) assay has been described for the determination of asenapine(ASE) in presence of its inactive metabolites N-desmethyl asenapine(DMA) and asenapine-N-glucuronide(ASG). ASE, and ASE 13C-d3, used as internal standard(IS), were extracted from 300 mL human plasma by a simple and precise liquid-liquid extraction procedure using methyl tert-butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP_(8e)(100 mm×4.6 mm) column using acetonitrile-5.0 mM ammonium acetate-10% formic acid(90:10:0.1, v/v/v) within 4.5 min. Quantitation of ASE was done on a triple quadrupole mass spectrometer equipped with electrospray ionization in the positive mode. The protonated precursor to product ion transitions monitored for ASE and ASE 13C-d3 were m/z 286.1→166.0 and m/z 290.0→166.1, respectively. The limit of detection(LOD) and limit of quantitation(LOQ) of the method were 0.0025 ng/mL and 0.050 ng/mL respectively in a linear concentration range of 0.050–20.0 ng/mL for ASE. The intra-batch and inter-batch precision(% CV) and mean relative recovery across quality control levels were ≤5.8% and 87.3%, respectively. Matrix effect, evaluated as IS-normalized matrix factor, ranged from 1.03 to 1.05. The stability of ASE under different storage conditions was ascertained in presence of the metabolites. The developed method is much simpler, matrix free, rapid and economical compared to the existing methods. The method was successfully used for a bioequivalence study of asenapine in healthy Indian subjects for the first time. | Nirav R Patel Mallika Sanyal Naveen Sharma Dinesh S.Patel Pranav S.Shrivastav Bhavin N.Patel | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 1 |
| 8 | Set-up time reduction and mistake proofing methods:an examination in precision component manufacturing显示文摘 | S.Patel B.G.Dale P.Shaw | | 0，，03： | 1 |
| 9 | Monitoring Motor Fluctuations in Patients With Parkinson's Disease Using Wearable Sensors显示文摘 | S.Patel K.Lorincz R.Hughes N.Huggins | | 0，，06： | 1 |
| 10 | Safety and efficacy of linagliptin as add‐on therapy to metformin in patients with type 2 diabetes: a randomized, double‐blind, placebo‐controlled study显示文摘 | M.‐R.Taskinen J.Rosenstock I.Tamminen R.Kubiak S.Patel K. A.Dugi H.‐J.Woerle | 2010 | Diabetes Obesity and Metabolism2010，，1： | 1 |
| 11 | Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic‐induced neuroapoptosis in the rat developing brain显示文摘 | R. D.SANDERS P.SUN S.PATEL M.LI M.MAZE D.MA | 2010 | Acta Anaesthesiologica Scandinavica2010，，6： | 1 |
| 12 | TBI or not TBI: that is the question. Is it better to measure toe pressure than ankle pressure in diabetic patients?显示文摘 | B.Brooks R.Dean S.Patel B.Wu L.Molyneaux D. K.Yue | 2001 | Diabetic Medicine2001，，7： | 1 |
| 13 | Outcome of prenatally diagnosed isolated clubfoot显示文摘 | S.Lauson C.Alvarez M. S.Patel S.Langlois | 2010 | Ultrasound Obstet Gynecol2010，，6： | 1 |
| 14 | Electrostatic complementarity of B-cell receptor CDR3s and TP53-mutant amino acids in breast cancer is associated with increased disease-free survival rates显示文摘Breast cancer has long been characterized as a B-cell-related disease with regard to the immune response.For example,data have indicated that B-cell receptor(BCR)recombination read recoveries from breast cancer exome(WXS)files revealed an increased disease-free survival(DFS)rate.1 However,the antigens stimulating the B-cell response have not been well characterized,particularly via immunogenomics analyses.Thus,we evaluated the net charge per residue(NCPR)for CDR3s,for BCRs expressed on tumor-infiltrating lymphocytes(TILs),to assess its electrostatic complementarity with TP53-mutant amino acids(AAs),because the CDR3 loop domain is the most important part of the BCR polypeptide for antigen-binding specificity. | Juan F.Arturo Boris I.Chobrutskiy Michelle Yeagley Dhruv N.Patel Shayan Falasiri Jay S.Patel George Blanck | 2020 | Cellular & Molecular Immunology2020，17，7： | 0 |
| 15 | Synthesis of some novel divalent transition metal complexes as antimicrobials显示文摘转变金属建筑群的一个新奇系列从 5- 的反应被综合了((有转变金属盐的 3-(methylthio )-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-ylamino)methyl)quinolin-8-ol。这些混合物的结构被元素、光谱的分析阐明了。而且,混合物被屏蔽为在对代表性的面板的 vitro 抗菌剂活动二克积极并且二个克否定的细菌和真菌的二紧张。各种各样的混合物表演有势力对测试有机体的禁止的行动。 | Kaushal K.Oza Paresh N.Patel Hasmukh S.Patel | 2011 | Chinese Chemical Letters2011，22，8： | 0 |
| 16 | Effect of partial blockage of air duct outlet on performance of OWC device显示文摘The use of a Savonius rotor as turbine for an oscillating water column(OWC) is demonstrated.The effect of tuning the OWC using turbine duct blockage is also studied for different wave conditions.A horizontal turbine section OWC employing a Savonius rotor was tested by varying the opening of OWC exit(0%,25%,50%,75% and 100%) to study the behavior and performance of the device.The OWC model was tested at water depth of 0.29 m at frequencies of 0.8,0.9 and 1.0 Hz while the exit openings are varied.The static pressure,dynamic pressure,rotational speed of the Savonius rotor and the coefficient of power are presented as results.The OWC with exit opening of 25% showed greater performance in terms of rotational speed and CP compared to OWC with other exit opening percentages.This proves the ability of the OWC to be tuned by regulating flow in the turbine duct. | S.Patel K.Ram M.Rafiuddin Ahmed | 2012 | Journal of Central South University2012，19，3： | 0 |
| 17 | Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl)-quinolin-8-ol and its metal complexes显示文摘A novel 5-((4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol(HTPSMQol) was synthesized by optimized reaction of 4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)aniline with 5-chloromethyl-8-hydroxy-quinoline hydrochloride(CMHQ).Also complexes of HTPSMQol were prepared by using various M(Ⅱ) metal salts.All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms.The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin. | Paresh N.Patel Khyati D.Patel Hasmukh S.Patel | 2011 | Chinese Chemical Letters2011，22，11： | 0 |
| 18 | 一例慢性乙肝患者甲胎蛋白检测结果的差异所带来的挑战显示文摘Introduction Alpha-fetoprotein(AFP)is the most abundant serum protein found in the human fetus,produced by the yolk sac and the liver[1].The levels of maternal serum AFP reach a peak value at28-32 weeks of gestation and decrease rapidly after birth and usually drop to the normal at 8-12 months of age.The normal serum AFP level for an adult is<20 ng/mL[2].In contrast,livertumor cells usually synthesize and secrete an increased level of AFP.Abdominal ultrasound and AFP are generally recommended as the screening modality for HCC for patients at risk for development of hepatocellular carcinoma(HCC)[1].AFP-L3,an isoform of AFP that binds Lens culinaris agglutinin,can be particularly useful in the early identification of aggressive HCC[2].These assays,however,can generate false-positive and false-negative AFP values.Of patients with advanced HCC,20%had normal AFP levels,whereas some patients with liver diseases had significant AFP elevation without liver cancer in long-term surveillance[3].Elevated AFP levels could be associated with active liver diseases with hepatocyte regeneration[4,5].In that setting,the AFP level will decline with improvement of the underlying liver condition.Our case illustrated the dilemma and uncertainties as a result of persistent abnormal AFP values after extensive clinical investigations. | Pir A.Shah Allison Onken Rizwan Ishtiaq Muhammad H.Maqsood Shyam S.Patel Karen J.Campoverde Reyes Adrianna Z.Herskovits Daryl T.Y.Lau | 2020 | Gastroenterology Report2020，8，6： | 0 |
| 19 | 纳米复合胶粘剂的合成与性能显示文摘用溶液聚合法合成了一系列丙烯酸乙酯(EA)、丙烯酸丁酯(BA)和丙烯酸(AA)的二元和三元共聚物。分别用溶胶-凝胶法和溶解混合法制得了丙烯酸酯共聚物和二氧化硅或粘土的纳米胶粘剂。在铝(Al)、木材(W)和双向拉伸聚丙烯(PP)这三种不同表面性能的基材上,用测定剥离强度、搭接剪切强度和静态剪切强度的方法,考察了纳米粒子对复合胶粘剂性能的影响。研究发现,随着聚合物极性的增加、纳米填料含量的增加,铝-铝和PP—PP粘接件的剥离强度显著提高,这是由于纳米胶粘剂具有更高的附着强度。对于纯丙烯酸酯胶粘剂,测试时的破坏部位在界面处,而对于纳米胶粘剂,其破坏的性质为粘-滑断裂。纳米胶粘剂的搭接剪切强度和静态剪切强度均随纳米填料含量的增加而增大。由于基材表面羟基基团存在的相互作用,因此,铝-铝和木材-木材显示出的粘接强度较高。 | S.Patel | 2007 | 丙烯酸化工与应用2007，20，3： | 0 |
| 20 | Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study显示文摘A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry(LC–MS/MS) assay has been developed for the simultaneous determination of doxepin(Dox) and its pharmacologically active metabolite, nordoxepin(NDox) in human plasma. The analytes and their internal standards(IS)were extracted from 500 m L of human plasma by liquid-liquid extraction using methyl tert-butyl ether.Chromatographic separation was achieved on Hypurity C8 column(100 mm ? 4.6 mm, 5 mm) using a mixture of acetonitrile-methanol(95:5, v/v) and 2.0 mM ammonium formate in 93:7(v/v) ratio. Detection was accomplished by tandem mass spectrometry in the positive ionization and multiple reaction monitoring acquisition mode. The protonated precursor to product ion transitions studied for Dox, NDox,and their corresponding ISs, propranolol and desipramine, were m/z 280.1-107.0, 266.0-107.0,260.1-116.1 and 267.1-72.1, respectively. A linear dynamic range of 15.0–3900 pg/mL for Dox and 5.00–1300 pg/mL for NDox was established with mean correlation coefficient(r2) of 0.9991 and 0.9993, respectively. The extraction recovery ranged from 86.6%–90.4% and 88.0%–99.1% for Dox and NDox, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was r 8.3% for both the analytes. Stability evaluated under different storage conditions showed no evidence of degradation and the % change in stability samples compared to nominal concentration ranged from 4.7% to12.3%. The method was successfully applied to a bioequivalence study of 6 mg doxepin hydrochloride orally disintegrating tablet in 41 healthy Indian subjects under fasting and fed conditions. | Nirav P.Patel Mallika Sanyal Naveen Sharma Dinesh S.Patel Pranav S.Shrivastav Bhavin N.Patel | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 0 |
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