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| 1 | 132例合并原发性消化道癌的胃肠道间质瘤临床病理特征显示文摘目的:探讨合并原发性消化道癌的胃肠道间质瘤(gastrointestinal stromal tumors,GISTs)的临床病理特点。方法:回顾性分析689例GISTs患者的临床病理资料,从中筛选出132例合并原发性消化道癌的GISTs患者及512例单纯GISTs患者,对比分析其临床病理特征、免疫表型特征;部分合并原发性消化道癌的GISTs病例采用直接测序法检测c-Kit基因9,11,13和17外显子的突变情况,与已知GISTs基因突变情况进行比较。结果:合并原发性消化道癌的GISTs占同期全部GISTs的19.2%(132/689)。与单纯GISTs相比,其发病年龄较高,男性明显多于女性。GISTs最大径0.1~8.0(平均1.1)cm,其中92.4%(122/132)为小间质瘤;多数核分裂象<5个/50个高倍视野(HPF)。免疫组织化学显示CD117和CD34的阳性率均为97.7%(129/132),DOG-1阳性率99.2%(131/132),约94.7%的病例Ki-67阳性率<2%。绝大多数为低危和极低危;47.9%(23/48)的病例检测到c-Kit基因突变,均为11外显子的突变,未发现外显子9,13和17突变。其中52.2%(12/23)为点突变,是本组11外显子突变最常见的状态,其次是缺失突变,约为43.5%(10/23),插入突变约为4.3%(1/23)。结论:GISTs与消化道癌伴发并不是一个罕见的或特殊的现象,这种GISTs常发生在胃,绝大多数小GISTs,确诊需依靠病理,其形态学及免疫组织化学以及分子检测结果与单纯GISTs无明显差异。往往是偶然被发现,其潜在的恶性风险较低,GISTs复发的概率远低于原发癌,因此要避免过度治疗。 | 丁鑫 殷平 陈琪琪 廖洪锋 Annie S.Hong | 2020 | 临床与病理杂志2020，40，3： | 3 |
| 2 | 查看详情显示文摘 | K.Lang J.Park S.Hong | | 0，，： | 1 |
| 3 | Molecular and Biological Diversities of Cucumber green mottle mosaic virus from Cucurbitaceous Crops in Korea显示文摘 | J. Y.Yoon G. S.Choi S. K.Choi J. S.Hong J. K.Choi W.Kim G. P.Lee K. H.Ryu | 2008 | Journal of Phytopathology (鈥?)2008，，7： | 1 |
| 4 | Increased serum levels of L‐arginine in ulcerative colitis and correlation with disease severity显示文摘 | Shih‐Kuang S.Hong Brad E.Maltz Lori A.Coburn James C.Slaughter RupeshChaturvedi David A.Schwartz Keith T.Wilson | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
| 5 | The effects of post-adoption beliefs on the expectation-confirmation model for information technology continuance显示文摘 | Thong J.Y.L S.Hong | | 0，，09： | 1 |
| 6 | Microstructure and corrosion resistance of plasma sprayed Fe-based alloy coating as an alternative to hard chromium显示文摘 | W.H.Lu Y.P.Wu J.J.Zhang S.Hong J.F.Zhang and G.Y.Li | | 0，，： | 1 |
| 7 | Nanotube-Based Chemical and Biomolecular Sensors显示文摘We present a brief review about recent results regarding carbon nanotube(CNT)-based chemical and biomole- cular sensors.For the fabrication of CNT-based sensors,devices containing CNT channels between two metal electrodes are first fabricated usually via chemical vapor deposition(CVD)process or'surface programmed assembly'method.Then,the CNT surfaces are often functionalized to enhance the selectivity of the sensors. Using this process,highly-sensitive CNT-based sensors can be fabricated for the selective detection of various chemical and biological molecules such as hydrogen,ammonia,carbon monoxide,chlorine gas,DNA,glucose, alcohol,and proteins. | J.Koh B.Kim S.Hong H.Lim H.C.Choi | 2008 | Journal of Materials Science & Technology2008，24，4： | 1 |
| 8 | 查看详情显示文摘 | H. Sim J.n Kim S. Lee M.Song D.Yoon D.Lim S.Hong | | 0，，： | 1 |
| 9 | Structural Concrete Analysis Using Rigid‐Body‐Spring Networks显示文摘 | J. E.Bolander Jr. G. S.Hong K.Yoshitake | 2002 | Computer‐Aided Civil and Infrastructure Engineering2002，，2： | 1 |
| 10 | 'Resampling algorithms for particle filters:A computational complexity perspective,'显示文摘 | M.BOLIC P.M.DJURIC S.HONG | | 0，，15： | 1 |
| 11 | 查看详情显示文摘 | J.Choi J.S.Kim I.Hwang S.Hong I.S.Byun S.W.Lee S.O.Kang and B.H.Park | | 0，，26： | 1 |
| 12 | A bleaching herbicidal activity of methoxyhygromycin (MHM) produced by an actinomycete strain Streptomyces sp. 8E‐12显示文摘 | H.B.Lee C.‐J.Kim J.‐S.Kim K.‐S.Hong K.Y.Cho | 2003 | Letters in Applied Microbiology2003，，6： | 1 |
| 13 | An evidenced-based diagnostic tool for superior semicircular canal dehiscence syndrome显示文摘Purpose:To construct a symptoms-based prediction tool to assess the likelihood of superior canal dehiscence(SSCD)on high-resolution CT.Materials and methods:Mathematical modeling was employed to predict radiologic evidence of SSCD at a tertiary neurotology referral center.Results:A total of 168 patients were included,of which 118 had imaging-confirmed SSCD.On univariate analysis significant predictors of SSCD presence were:sound/pressure-induced vertigo(p?0.006),disequilibrium(p?0.008),hyperacusis(p?0.008),and autophony(p?0.034).Multivariate analysis enabled a 14-point symptom-weighted tool to be developed,wherein a score of6 raised the suspicion of SSCD(70%likelihood of being present),R2?0.853.Conclusions:The likelihood of SSCD on CT scan can be determined with a high degree of certainty based on symptoms recorded at presentation.Using the evidenced-based diagnostic tool validated herein,a score6 with any symptom combination justifies ordering a CT scan. | Christian G.Fritz Garrett G.Casale Lulia A.Kana Robert S.Hong | 2023 | Journal of Otology2023，18，4： | 0 |
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