|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytokeratms and carcinoembryonic antigen in diagnosis,staging and prognosis of colorectal adenocarcinoma显示文摘AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hundred blood donors formed the control group. Radical surgery was performed on 120 patients, with an average follow-up duration of 22.3 mo. Relapses occurred in 23individuals after an average of 18.09 mo. CEA was assayed via the Delfia(R) method with a limit of 5 ng/mL. Cytokeratins were assayed via the LIA-mat(R) TPA-M Prolifigen(R) method with a limit of 72 U/L.RESULTS: In the diagnosis of patients with colorectal adenocarcinoma, CEA showed a sensitivity of 56%, a specificity of 95%, a positive predictive value of 94%, a negative predictive value of 50% and an accuracy of 76.8%.TPA-M had a sensitivity of 70%, a specificity of 96%, a positive predictive value of 97%, a negative predictive value of 66% and an accuracy of 93.6%. The elevation of one of the markers was shown to have a sensitivity of 76.9%, a specificity of 91%, a positive predictive value of 93.5%, a negative predictive value of 70% and an accuracy of 83.6%.There was no variation in the levels of the markers according to the degree of cell differentiation while there was an elevation in their concentrations in accordance with the increase in neoplastic dissemination. There was a statistically significant difference between the patients with stage Ⅳ lesions and those with stages Ⅰ, Ⅱ and Ⅲ tumors.With regard to CEA, the averagelevel was 14.2 ng/mL in patients with stage Ⅰ lesions, 8.5 ng/mL in patients with stage Ⅱ lesions, 8.0 ng/mL in patients with stage Ⅲ lesions and 87.7 ng/mL in patients with stage Ⅳ lesions. In relation to TPA-M, the levels were 153.1 U/L in patients with stage Ⅰtumors, 106.5 U/L in patients with stage Ⅱ tumors, 136.3 U/L in patients with stage Ⅲ tumors and 464.3 U/L in patients with stage Ⅳ tumors. There was a statistical difference in patients with a high CEA level in relation to a shorter survival(P<0.05). However, there was no correlation between patients with high TPA-M levels and prognostic indices of patients undergoing radical surgery.CONCLUSION: Cytokeratins demonstrate a greater sensitivity than CEA in the diagnosis of colorectal adenocarcinoma.There is an increase in the sensitivity of the markers with tumor dissemination. Cytokeratins cannot identify the worse prognosis in patients undergoing radical surgery.Cytokeratins constitute an advance in the direction of a perfect tumor marker in the treatment of patients with colorectal cancer. | Luís C.Fernandes Su B.Kim Delcio Matos | 2005 | World Journal of Gastroenterology2005，11，5： | 21 |
| 2 | 胰腺癌的手术治疗现状显示文摘整块切除是局限性胰腺癌的治疗方法之一。切除相关围手术期病死率低,但在某些高风险患者中其并发症发生率高达50%。随着围手术期治疗护理水平的提高,包括毗邻血管的可获得阴性切缘的根治性切除已在大型医院里实施,早前在胰腺手术中使用微创技术的结果表明其应用前景良好。最新的关于如何降低胰腺相关手术围手术期并发症的数据,在此也将得到讨论。 | Charles B.Kim Shuja Ahmed Eddy C.Hsueh 王卓路(编译) 李新营(编译) | 2013 | 中国普通外科杂志2013，22，9： | 14 |
| 3 | High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma显示文摘Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its localization.Chimeric antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat cancer.IL-13-receptor-α2(IL13Rα2),present in over 75%of GBMs,has been recognized as an attractive candidate for antiglioblastoma therapy.Here,we propose a novel multidisciplinary approach to target brain tumors using a combination of fluorescent,therapeutic nanoparticles and CAR T cells modified with a targeted-quadruplemutant of IL13(TQM-13)shown to have high binding affinity to IL13Rα2-expressing glioblastoma cells with low off-target toxicity.Azide-alkyne cycloaddition conjugation of nanoparticles to the surface of T cells allowed a facile,selective,and high-yielding clicking of the nanoparticles.Nanoparticles clicked onto T cells were retained for at least 8 days showing that the linkage is stable and promising a suitable time window for in vivo delivery.T cells clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare T cells.In vitro and in vivo T cells expressing TQM-13 served as delivery shuttles for nanoparticles and significantly increased the number of nanoparticles reaching brain tumors compared to nanoparticles alone.This work represents a new platform to allow the delivery of therapeutic nanoparticles and T cells to solid tumors. | Gloria B.Kim Virginia Aragon-Sanabria Lauren Randolph Hali Jiang Joshua A.Reynolds Becky S.Webb Achuthamangalam Madhankumar Xiaojun Lian James R.Connor Jian Yang Cheng Dong | 2020 | Bioactive Materials2020，5，3： | 6 |
| 4 | Preparation of Fe-Si-B-Nb amorphous powder cores with excellent high-frequency magnetic properties显示文摘 | Kang E Y Yoon B.Kim | | 0，，304： | 1 |
| 5 | Compliance With Home Blood Pressure Monitoring Among Middle‐Aged Korean Americans With Hypertension显示文摘 | JiyunKim Hae‐RaHan HeejungSong JongEunLee Kim B.Kim Miyong T.Kim | 2010 | The Journal of Clinical Hypertension2010，，4： | 1 |
| 6 | Fe-based nanocrystalline alloy powder cores with excellent high frequency magnetic properties显示文摘 | Yoon B.Kim Jee K K | | 0，，： | 1 |
| 7 | Nanotube-Based Chemical and Biomolecular Sensors显示文摘We present a brief review about recent results regarding carbon nanotube(CNT)-based chemical and biomole- cular sensors.For the fabrication of CNT-based sensors,devices containing CNT channels between two metal electrodes are first fabricated usually via chemical vapor deposition(CVD)process or'surface programmed assembly'method.Then,the CNT surfaces are often functionalized to enhance the selectivity of the sensors. Using this process,highly-sensitive CNT-based sensors can be fabricated for the selective detection of various chemical and biological molecules such as hydrogen,ammonia,carbon monoxide,chlorine gas,DNA,glucose, alcohol,and proteins. | J.Koh B.Kim S.Hong H.Lim H.C.Choi | 2008 | Journal of Materials Science & Technology2008，24，4： | 1 |
| 8 | Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models显示文摘Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal studies.Due to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart diseases.Several methods are used to induce MI in the swine model.However,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental cost.Hence,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine model.We carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing system.The fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked condition.Interestingly,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days post-operation.This method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases. | Han B.Kim Seungman Jung Hyukjin Park Doo S.Sim Munki Kim Sanskrita Das Youngkeun Ahn Myung H.Jeong Jinah Jang Young J.Hong | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员