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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Epidemiology of perforated peptic ulcer:Age-and gender-adjusted analysis of incidence and mortality显示文摘AIM:To investigate the epidemiological trends in inci-dence and mortality of perforated peptic ulcer(PPU)in a well-defined Norwegian population. METHODS:A retrospective,population-based,single-center,consecutive cohort study of all patients diag-nosed with benign perforated peptic ulcer.Included were both gastric and duodenal ulcer patients admitted to Stavanger University Hospital between January 2001 and December 2010.Ulcers with a malignant neoplasia diagnosis,verified by histology after biopsy or resection,were excluded.Patients were identified from the hospitals administrative electronic database using pertinent ICD-9 and ICD-10 codes(K25.1,K25.2,K25.5, K25.6,K26.1,K26.2,K26.5,K26.6).Additional searches using appropriate codes for relevant laparoscopic and open surgical procedures(e.g.,JDA 60,JDA 61,JDH 70 and JDH 71)were performed to enable a complete identification of all patients.Patient demographics,presentation patterns and clinical data were retrieved from hospital records and surgical notes.Crude and adjusted incidence and mortality rates were estimated by using national population demographics data. RESULTS:In the study period,a total of 172 patients with PPU were identified.The adjusted incidence rate for the overall 10-year period was 6.5 per 100 000 per year(95%CI:5.6-7.6)and the adjusted mortality rate for the overall 10-year period was 1.1 per 100 000 per year(95%CI:0.7-1.6).A non-significant decline in ad-justed incidence rate from 9.7 to 5.6 occurred during the decade.The standardized mortality ratio for the whole study period was 5.7(95%CI:3.9-8.2),while the total 30-d mortality was 16.3%.No difference in in-cidence or mortality was found between genders.However,for patients≥60 years,the incidence increased over 10-fold,and mortality more than 50-fold,compared to younger ages.The admission rates outside office hours were high with almost two out of three(63%) admissions seen at evening/night time shifts and/or during weekends.The observed seasonal variations in admissions were not statistically significant. CONCLUSION:The adjusted incidence rate,seasonal distribution and mortality rate was stable.PPU fre-quently presents outside regular work-hours.Increase in incidence and mortality occurs with older age. | Kenneth Thorsen Jon Arne Sreide Jan Terje Kvaly Tom Glomsaker Kjetil Sreide | 2013 | World Journal of Gastroenterology2013，19，3： | 14 |
| 3 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 4 | 单绒毛膜双羊膜囊性双胎妊娠的合并症及处理方式(Ⅱ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，2： | 8 |
| 5 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 6 | 单绒毛膜双羊膜囊性双胎妊娠合并症及处理方式(Ⅰ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，1： | 7 |
| 7 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 8 | From portal to splanchnic venous thrombosis:What surgeons should bear in mind显示文摘The present study aims to review the evolution of surgical management of portal(PVT) and splanch-nic venous thrombosis(SVT) in the context of liver transplantation over the last 5 decades. PVT is more commonly managed by endovenous thrombectomy, while SVT requires more complex technical expedients. Several surgical techniques have been proposed, such as extensive eversion thrombectomy, anastomosis to collateral veins, reno-portal anastomosis, cavo-portal hemi-transposition, portal arterialization and combined liver-intestinal transplantation. In order to achieve satisfactory outcomes, careful planning of the surgical strategy is mandatory. The excellent results that are ob-tained nowadays confirm that, even extended, splanch-nic thrombosis is no longer an absolute contraindication for liver transplantation. Patients with advanced portal thrombosis may preferentially be referred to specialized centres, in which complex vascular approaches and even multivisceral transplantation are performed. | Quirino Lai Gabriele Spoletini Rafael S Pinheiro Fabio Melandro Nicola Guglielmo Jan Lerut | 2014 | World Journal of Hepatology2014，6，8： | 6 |
| 9 | Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs显示文摘The intestinal microbiota is the collection of the living microorganisms(bacteria, fungi, protozoa, and viruses) inhabiting the gastrointestinal tract. Novel bacterial identification approaches have revealed that the gastrointestinal microbiota of dogs and cats is, similarly to humans, a highly complex ecosystem. Studies in dogs and cats have demonstrated that acute and chronic gastrointestinal diseases, including inflammatory bowel disease(IBD), are associated with alterations in the small intestinal and fecal microbial communities. Of interest is that these alterations are generally similar to the dysbiosis observed in humans with IBD or animal models of intestinal inflammation, suggesting that microbial responses to inflammatory conditions of the gut are conserved across mammalian host types. Studies have also revealed possible underlying susceptibilities in the innate immune system of dogs and cats with IBD, which further demonstrate the intricate relationship between gut microbiota and host health. Commonly identified microbiome changes in IBD are decreases in bacterial groups within the phyla Firmicutes and Bacteroidetes, and increases within Proteobacteia. Furthermore, a reduction in the diversity of Clostridium clusters XIVa and IV(i.e., Lachnospiraceae and Clostridium coccoides subgroups) are associated with IBD, suggesting that these bacterial groups may play an important role in maintenance of gastrointestinal health. Future studies are warranted to evaluate the functional changes associated with intestinal dysbiosis in dogs and cats. | Julia B Honneffer Yasushi Minamoto Jan S Suchodolski | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 10 | Hot deformation of Mg-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction显示文摘The compressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy containing a low amount of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction technique.Tests were conducted at temperatures between room temperature and 350℃.Detailed microstructure investigation was provided by scanning electron microscopy,particularly the backscattered electron imaging and electron backscatter diffraction technique.The results show that twinning lost its dominance and kinking of the LPSO phase became more pronounced with increasing deformation temperature.No cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deformation of the alloy was mainly realized by the dynamic recrystallization of the Mg matrix. | Klaudia Horváth Fekete Daria Drozdenko Jan Capek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 11 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 12 | A post-classical theory of enamel biomineralization… and why we need one显示文摘Enamel crystals are unique in shape,orientation and organization.They are hundreds of thousands times longer than they are wide,run parallel to each other,are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel.The classical theory of amelogenesis postulates that extracellular matrix proteins shape crystallites by specifically inhibiting ion deposition on the crystal sides,orient them by binding multiple crystallites and establish higher levels of crystal organization.Elements of the classical theory are supported in principle by in vitro studies;however,the classical theory does not explain how enamel forms in vivo.In this review,we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape,orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane. | James P Simmer Amelia S Richardson Yuan-Yuan Hu Charles E Smith Jan Ching-Chun Hu | 2012 | International Journal of Oral Science2012，4，3： | 4 |
| 13 | POD-Kriging降阶方法在串联双圆柱流场预测中的应用显示文摘串联双圆柱是研究起落架噪声机理以及不同部件之间流动相互作用的经典算例,而距径比(圆柱柱心间距与直径的比值)是该构型非常重要的参数,随着距径比的改变,流场形态会发生明显变化。为更清晰地分析串联双圆柱流场的非定常效应和流场形态随距径比的变化规律,采用本征正交分解方法(POD)提取流场降阶基模态,再通过Kriging模型插值出待求的各模态投影系数,分别对串联双圆柱定参数非定常流场和变距径比时均流场建立降阶模型,为保证样本精度,快照数据的采集采用基于SST湍流模型的尺度自适应模型(SAS)。通过降阶模型预测的圆柱流场与数值计算及实验数据的对比,证明了模型的精度与效率,然后利用建立的降阶基总结了时均流场随距径比大小的变化规律。 | 王晨 白俊强 Jan S Hesthaven 邱亚松 乔磊 韩啸 | 2018 | 西北工业大学学报2018，36，2： | 3 |
| 14 | Molecule-based kinetic modeling by Monte Carlo methods for heavy petroleum conversion显示文摘A methodology for kinetic modeling of conversion processes is presented.The proposed approach allows to overcome the lack of molecular detail of the petroleum fractions and to simulate the reactions of the process by means of a two-step procedure.In the first step,a synthetic mixture of molecules representing the feedstock is generated via a molecular reconstruction method,termed SR-REM molecular reconstruction.In the second step,a kinetic Monte Carlo method,termed stochastic simulation algorithm(SSA),is used to simulate the effect of the conversion reactions on the mixture of molecules.The resulting methodology is applied to the Athabasca vacuum residue hydrocracking.An adequate molecular representation of the vacuum residue is obtained using the SR-REM algorithm.The reaction simulations present a good agreement with the laboratory data for Athabasca vacuum residue conversion.In addition,the proposed methodology provides the molecular detail of the vacuum residue conversion throughout the reactions simulations. | de OLIVEIRA Luís Pereira VERSTRAETE Jan J. KOLB Max | 2013 | Science China Chemistry2013，56，11： | 3 |
| 15 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martínez-Llordella Marc Lozano Juan José Puig-Pey Isabel Orlando Giuseppe Tisone Giuseppe Lerut Jan Benítez Carlos Pons Jose Antonio Parrilla Pascual Ramírez Pablo Bruguera Miquel Rimola Antoni Sánchez-Fueyo Alberto | 2008 | Journal of Clinical Investigation2008，，8： | 3 |
| 16 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 17 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 18 | Complex hepatic outflow reconstruction in domino liver transplantation显示文摘Domino liver transplantation has been accepted as a safe procedure to further expand the organ donor pool. The most important technical challenge of the procedure resides in restoring a proper hepatic venous allograft outflow in the familial amyloidotic polyneuropathy-liver recipient. To overcome this issue, combined techniques were used to perform an innovative outflow reconstruction. A domino liver transplantation was successfully performed with reconstruction of complex venous outflow. The inferior vena cava sparing hepatectomy technique in the familial amyloidotic polyneuropathy-donor was used to cut the hepatic vein to the liver parenchyma. To overcome this issue the venous outflow tract was reconstructed using a longitudinally opened iliac vein graft from a post-mortem donor to create a new outflow tract using a diamond patch between the right and middle/left hepatic veins. | Rafael S Pinheiro Quirino Lai Carola Dahrenmoller Jan Lerut | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 2 |
| 19 | The Place of Liver Transplantation in the Treatment of Hepatic Epitheloid Hemangioendothelioma: Report of the European Liver Transplant Registry显示文摘 | Jan P. Lerut Giuseppe Orlando Rene Adam Marcello Schiavo Jurgen Klempnauer Darius Mirza Emmanuel Boleslawski Andrew Burroughs Carlos Fernandez Sellés Daniel Jaeck Robert Pfitzmann Mauro Salizzoni Gunner S?derdahl Rudi Steininger Andre Wettergren Vincenzo | 2007 | Annals of Surgery2007，，6： | 2 |
| 20 | Morphology‐function relationships and repeatability in the sperm of Passer sparrows显示文摘 | Emily R.A. Cramer Terje Laskemoen Even Stensrud Melissah Rowe Fredrik Haas Jan T. Lifjeld Glenn‐Peter S?tre Arild Johnsen | 2015 | Journal of Morphology2015，，： | 2 |
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