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| 1 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction显示文摘在里面结合不孕, 0% 正常形式(NF ) 的反常严格的形态学是一个标准很快继续到在 vitro 授精(IVF ) 。自从没有数据,当前存在,我们与 0% NF 为人调查了结果没有帮助繁殖技术(艺术) 的使用,决定繁殖成功。有 0% NF 的 24 个人的一个队被识别(2010-2013 ) 随机与 ≥ 与 27 选择了人;是的 4% NF 控制。耐心的图表与联系并且管理同意的一块机构的评论板(IRB ) 的人一起被考察查明结果的电话问询表。在 2.5 年的一中部的后续时间以后,有 0% NF 的 29.2% 人没为他们的第一怀孕要求艺术(控制 =55.6% , P ≤0.05 ) 。当所有怀孕一起被分析时,有 0% NF 的人完成了 75% 没要求 IVF 的二十怀孕(控制 = 三十怀孕;76.7% 没要求 IVF ) 。人和女搭挡的平均年龄在有 0% NF 和 ≥ 的人之间是类似的; 4% NF。所有人有正常刺激滤泡的荷尔蒙(FSH ) ,睾丸激素,催乳激素,性别荷尔蒙绑定血球素(SHBG ) ,和 estradiol。尽管,当第一怀孕是一个自然概念(NC ) 时,全球精液参数在有 0% NF 的人是更坏的,有 0% NF (n = 7/7 ) 的人的 100% 并且 37.5% 控制(n = 3/8 ) 继续了经由 NC 有随后的怀孕。没有 IVF,有 0% NF 的人与 55.6% 控制相比在 29.2% 盒子中怀孕了。严格的形态学不应该被用来预言授精,怀孕,或实时出生潜力。在有 0% NF 的人,其他的形式应该被认为 IVF 以前立即。 | Jason R Kovac Ryan P Smith Miguel Cajipe Dolores J Lamb Larry I Lipshultz | 2017 | Asian Journal of Andrology2017，19，1： | 7 |
| 3 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 4 | Developmental and Feedforward Control of the Expression of Folate Biosynthesis Genes in Tomato Fruit显示文摘很少植物怎么调整他们的叶酸的内容被知道,包括叶酸的生合成基因的表达式是否在开发期间被安排或由叶酸的层次调制了。也很不叶酸的层次怎么影响另外的基因的表示被知道。这些点用为高叶酸的内容设计的野类型的西红柿水果和水果被探讨。在野类型的水果,在叶酸的生合成指定早步的基因的表示在开发而是另外的基因的期间衰退了。在设计水果 overexpressing 外国 GTP cyclohydrolase 我和 aminodeoxychorismate synthase 基因,各自的内长的基因的表示没变化,但是三下游的小径 genesaminodeoxychorismate lyase , dihydroneopterin aldolase ,和 mitochondrial folylpolyglutamate 的 synthaserespectively 增加了由直到7.8-,2.8-,和1.7褶层,显然响应特定的叶酸的小径代谢物的逐渐增加。这些结果显示在水果,某些叶酸的小径基因发展地被调整并且某些其它由小径中介服从于前馈控制控制。Microarray 分析显示出那仅仅 14 个另外的抄本(11 ? 000 调查了) 在丰富增加了由双重或更在里面高度叶酸的水果,证明叶酸的小径基因的正式就职是相对特定的。 | Jeffrey C. Wallera Tariq A. Akhtar Aurora Lara-Nunez Jesse F. Gregory lli Ryan R McQuinn James J. Giovannoni Andrew D. Hanson | 2010 | Molecular Plant2010，3，1： | 5 |
| 5 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 6 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 7 | A rapid dehydration leaf assay reveals stomatal response differences in grapevine genotypes显示文摘A simple and reliable way of phenotyping plant responses to dehydration was developed.Fully-developed leaves were detached and placed in a closed plastic box containing a salt solution to control the atmospheric water potential in the container.Three hours of dehydration(weight loss of the leaf)was optimal for measuring changes in stomatal response to dehydration.Application of the plant hormone abscisic acid(ABA)prior to leaf detachment decreased the amount of water loss,indicating that the assay was able to detect differences based on a stomatal response to dehydration.Five different Vitis genotypes(V.riparia,V.champinii,V.vinifera cv.Shiraz,V.vinifera cv.Grenache and V.vinifera cv.Cabernet Sauvignon)with known differences in drought tolerance were screened for their dehydration response and the results obtained corresponded to previous reports of stomatal responses in the vineyard.Significant differences in stomatal density along with differences in the amount and rate of water lost indicate differences in dehydration sensitivity among the genotypes screened.Differences in stomatal response to ABA were also detected.Shiraz had the lowest stomatal density and the highest ABA sensitivity among the genotypes screened,yet Shiraz lost the most amount of water,indicating that it was the least sensitive to dehydration.Despite having the highest stomatal density and intermediate stomatal sensitivity to ABA,V.riparia lost the smallest amount of water,indicating that it was the most sensitive to dehydration.The assay presented here represents a simple and reliable phenotyping method for plant responses to leaf dehydration. | Daniel W Hopper Ryan Ghan Grant R Cramer | 2014 | Horticulture Research2014，1，1： | 2 |
| 8 | Implantation potential and fetal viability of mouse embryos cultured in media supplemented with platelet activating factor 显示文摘 | Ryan J P Spinks N R O'Neill C | 1990 | J Reprod Fertil1990，89，： | 2 |
| 9 | Appendectomy and Clostridium difficile colitis:Relationships revealed by clinical observations and immunology显示文摘Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon.These advances have been made despite long standing clinical observations that the appendectomy is a safe and effective procedure.However,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(C.difficile)-associated colitis,and probably other diseases associated with an altered microbiome.At the same time,appendectomy does not apparently put patients at risk for an initial onset of C.difficile-associated colitis.These clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of C.difficile-associated colitis.Further,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics. | Nathan L Sanders R Randal Bollinger Ryan Lee Steven Thomas William Parker | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 10 | Aluminium tolerance in plants and the complexing role of organic acids显示文摘 | Jian Feng Ma Peter R Ryan Emmanuel Delhaize | 2001 | Trends in Plant Science2001，，6： | 2 |
| 11 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 12 | ZD6474 - a novel inhibitor of VEGFR and EGFR tyrosine kinase activity 显示文摘 | RYAN A J WEDGE S R | 2005 | Br J Cancer2005，92，1： | 1 |
| 13 | Further examining the American dream:Differential correlates of intrinsic and extrinsic goals显示文摘 | KASSER T RYAN R M | 1996 | Personality and Social Psychology Bulletin1996，22，： | 1 |
| 14 | An IL 7- dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency显示文摘 | Ryan MR Shepherd R Leavey JK | 2005 | Proc Natl AeadSci USA2005，102，16： | 1 |
| 15 | The inhibi- tion of aluminum alloy corrosion by cerium cations 显示文摘 | Hinton B R W Arnott D R Ryan N E | 1984 | Metals Forum1984，7，： | 1 |
| 16 | Wound-induced proteinase inhibitor in plant leaves:a possible defense mechanism against insects显示文摘 | GREEN T R RYAN C A | 1972 | Science1972，175，： | 1 |
| 17 | 显示文摘 | Demetrius M Ryan J George R | 2002 | JAMA2002，288，： | 1 |
| 18 | Maintenance respiration and stand development in a subalpine lodgepole pine forest显示文摘 | Ryan M G Waring R H | 1992 | Ecology1992，73，： | 1 |
| 19 | PAPNET-direeted resereening of cervicovaginal smears:a study of 101 cases of atypical squamous cells of undetermined significauce显示文摘 | Ryan M R Stastny J F Remmers R | 1996 | Am J Clin Pathol1996，105，6： | 1 |
| 20 | Cerium conversion coatings for the corrosion protection of aluminum 显示文摘 | Hinton B R W Aruott D R Ryan N E | 1986 | Materials Forum1986，9，3： | 1 |
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