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| 1 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 2 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 3 | Assessment of hunger in growing broiler breeders in relation to a commercial restricted feeding programme 显示文摘 | Savory C J Maros K Rutter S M | 1993 | Anim Welf1993，2，： | 1 |
| 4 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 5 | Characterization of cell lines carrying self-replicating hepatitis C virus RNAs显示文摘 | Pietschmann T Lohmann V Rutter G Kurpanek K Bartenschlager R | | 0，，03： | 1 |
| 6 | Hospitalization, fre- quency of interventions, and quality of life after endoscop- ic,surgical, or conservative treatment in patients with chro- nic pancreatitis显示文摘 | Rutter K Ferlitsch A Sautner T | 2010 | World J Surg2010，34，11： | 1 |
| 7 | Impact of the atherosclerotic process in patients with diabetes显示文摘 | Nesto R W Rutter M K | 2002 | Acta Diabetol2002，39，： | 1 |
| 8 | The redistribu- tion of solute atoms during the solidification of metals 显示文摘 | Tiller W A Jackson K A Rutter J W | 1953 | Acta Metall1953，1，4： | 1 |
| 9 | Role of vitamin D in the development of insulin resistance and type 2 diabetes显示文摘 | Pilz S Kienreich K Rutters F | 2013 | Curr Diab Rep2013，13，2： | 1 |
| 10 | The effects of repeated planting, planting density, and specific transfer pathways on PCB uptake by Cucurbita pepo grown in fiel conditions显示文摘 | Aslund M L W Rutter A Reimer K J | 2008 | Science of The Total Environment2008，405，13： | 1 |
| 11 | Enhanced external counterpulsation for the relief of angina in patients with diabetes: safety, efficacy and 1-year clinical outcomes显示文摘 | Georgiann Linnemeier Martin K Rutter Gregory Barsness Elizabeth D Kennard Richard W Nesto | 2003 | American Heart Journal2003，，3： | 1 |
| 12 | Dialysis treatment is an independent risk factor for foot ulceration in patients with diabetes and stage 4 or 5 chronic kidney disease 显示文摘 | Ndip A Rutter M K Vileikyte L | 2010 | Diabetes Care2010，33，8： | 1 |
| 13 | The Redistribution of Solute Atoms During the Solidification of Metals显示文摘 | Jackson K A Rutter J W | 1953 | Acta Metall1953，，1： | 1 |
| 14 | Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient显示文摘 | Payer BA Reiberger T Rutter K | 2010 | J Clin Virol2010，49，2： | 1 |
| 15 | Opening of Cyclic Acetals by Trichloro-, Dichloro, and Tribrmo-borane显示文摘 | Bonner T G Lewis D Rutter K | 1981 | J Chem Soc Perkin Trans I1981，，18： | 1 |
| 16 | Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex -related differences in the Framingham Heart Study 显示文摘 | RUTTER M K BENJAMIN E J LARSON M G | 2003 | Circulation2003，107，3： | 1 |
| 17 | Greon tea extract suppresses the agerelated increase in collagen erosslinking and fluorescent products in C57BL/6 mice显示文摘 | Rutter K Sell DR Fraser N | 2003 | Int J Vitam Nutr Res2003，73，： | 1 |
| 18 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE3rd Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A McLean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 19 | Portal pressure predicts outcome and safety of antiviral therapy in cirrhotic patients with hepatitis C virus infection显示文摘 | Reiberger T Rutter K Ferlitsch A | 2011 | Clin Gastroenterol Hepatol2011，9，7： | 1 |
| 20 | Thirty-year analysis of a colonoscopic surveil- lance program for neoplasia in ulcerative colitis 显示文摘 | RUTTER M D SAUNDERS B P WILKINSON K H | 2006 | Gastroenterology2006，130，： | 1 |
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