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| 1 | Major regulatory mechanisms involved in sperm motility显示文摘涉及鞭子部件以及在 flagellar 运动的规定的汇编和函数的基因库和分子的机制充分没被理解,特别在人。为精子无法移动,一些能被避免并且改正有几个原因,而其它与基因缺点有关并且值得完整的调查把诊断给病人。这评论在科学的联机数据库 PubMed, ScienceDirect,和网上在广泛的文学搜索以后被执行。这里,我们考察为精子活动性负责的规章的小径的参与,显示为精子无法移动的可能的原因。这些包括了钙小径,营地依赖者蛋白质 kinase 小径, kinases 和磷酸酶的重要性,反应的氧种类的功能,并且房间体积和 osmolarity 的规定怎么也是基本部件。我们然后讨论与特定的词法畸形联系的主要基因缺点。最后,我们稍微讨论某预防措施和治疗途径避免与未特别指出的精子无法移动被联系的条件的开发。我们在不久的将来相信那,与更强大的技术,精子无法移动的基因原因和活动性将是的精子的规章的机制的发展更好理解,因此启用执行完整的诊断并且揭开新治疗。 | Rute Pereira Rosalia Sa Alberto Barros Mario Sousa | 2017 | Asian Journal of Andrology2017，19，1： | 12 |
| 2 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 3 | Enhanced CO_(2)electroreduction to ethylene via strong metal-support interaction显示文摘The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density of 18 mA cm^(-2).The strong metal-support interaction could not only enhance the adsorption and activation of CO_(2),but also can stablize the CuO. | Mengen Chu Chunjun Chen Yahui Wu Xupeng Yan Shuaiqiang Jia Ruting Feng Haihong Wu Mingyuan He Buxing Han | 2022 | Green Energy & Environment2022，7，4： | 3 |
| 4 | Oxidative coupling of cinnamic acid derivatives and their radical-scavenging activities显示文摘4-Hydroxycinnamic acid derivatives,including ferulic acid (FA) (1),sinapic acid (SA) (2) and caffeic acid (CA) (3),are widely distributed in the plant kingdom,and undergo oxidative cross-coupling leading to the corresponding dehydrodimers,trimers and even higher oligomers in plants. In order to evaluate the antioxidative ability of these 4-hydroxycinnamic acid derivatives and their oligomers,we synthesized 8-8'-bis-lactone-dimers (8-8'-DiFA (4),8-8'-DiSA (5) and 8-8'-DiCA (6)),as well as a new trimer (7),by the reaction of the corresponding monomers (1-3) with Ag2O in methanol,and assayed their free radical-scavenging activity by the reaction with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·). It was found that CA (3) and 8-8'-DiCA (6) bearing o-dihydroxyl groups exhibited significantly higher radical-scavenging activity than those bearing no such groups,and oxidative coupling of CA (3) resulted in remarkable enhancement in the activity. | JIN XiaoLing YANG RuTing SHANG YaJing DAI Fang QIAN YiPing CHENG LiXia ZHOU Bo LIU ZhongLi | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 5 | Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota显示文摘This research aimed to investigate the antidiabetic activity,underlying mechanisms,and gut microbiota regulation of aloin.The insulin-resistant HepG2(IR-HepG2)cell model and the type 2 diabetic(T2D)mouse model were successfully established using dexamethasone and a high-fat high-sucrose diet with low-dose streptozotocin,respectively.Aloin intervention increased glucose consumption and stimulated the activity of hexokinase and pyruvate dehydrogenase in IR-HepG2 cells.Additionally,it diminished the weight loss,reduced fasting blood glucose levels and hemoglobin A1c activity,and promoted glucose tolerance and fasting serum insulin activity in T2D mice.Histopathological analysis of the liver indicated hepatic protection by aloin.Additionally,aloin treatment inhibited the protein expression of c-Jun N-terminal kinases and activated that of IRS1/PI3K/Akt in the liver.Moreover,aloin modulated the bacterial community in the gut by raising the abundance of Bacteroidota and reducing the richness of Firmicutes,Proteobacteria,and Actinobacteriota.Thus,aloin ameliorated IR via activating IRS1/PI3K/Akt signaling pathway and regulating the gut microbiota,and it may be promising candidate as functional food for diabetic therapy. | Ruting Zhong Lanbin Chen Yuanyuan Liu Shouxia Xie Sumei Li Bin Liu Chao Zhao | 2022 | Food Science and Human Wellness2022，11，1： | 2 |
| 6 | Lanthanide-based downshifting layers tested in a solar car race显示文摘The mismatch between the AM1.5G spectrum and the photovoltaic (PV) cells absorption is one of the most limiting factors for PV performance.To overcome this constraint through the enhancement of solar energy harvesting,luminescent downshifting (LDS) layers are very promising to shape the incident sunlight and,thus,we report here the use of Tb^3+- and Eu^3+-doped organic-inorganic hybrid materials as LDS layers on Si PV cells.Electrical measurements on the PV cell,done before and after the deposition of the LDS layers,confirm the positive effect of the coatings on the cell’s performance in the UV spectral region.The maximum delivered power and the maximum absolute external quantum efficiency increased 14% and 27%,respectively.Moreover,a solar powered car race was organized in which the small vehicle containing the coated PV cells presented a relative increase of 9% in the velocity,when compared to that with the uncoated one. | Sandra F.H.Correia Ana R.N.Bastos Lianshe Fu Luís D.Carlos Paulo S.André Rute A.S.Ferreira | 2019 | Opto-Electronic Advances2019，2，6： | 1 |
| 7 | Modelling the metabolic action of human and rat CYP1A2 and its relationship with the carcinogenicity of heterocyclic amines显示文摘 | Rute Da Fonseca Maria Cristina Menziani Andre Melo | 2003 | Molecular Physics2003，，17： | 1 |
| 8 | Somatostatin 4 regulates growth and modulates gametogenesis in zebrafish显示文摘Somatostatin(SST)plays important roles in growth and development.In teleost fishes six SST encoding genes(sst1 to sst6)have been identified although few studies have addressed their function.Here we aim to determine the function of the teleost specific sst4 in the zebrafish.A CRISPR/Cas9 sst4 zebrafish mutant with loss of function(sst4−/−)was produced which grew significantly faster and was heavier at the onset of gonadal maturation than the wild type(WT).Consistent with their faster growth,liver igf1,igf2a and igf2b expression was significantly upregulated in the sst4−/−fish compared to the WT.Histological examination of the ovaries and testis indicated that sst4−/−fish had slightly delayed testicular gametogenesis compared to the WT.Significantly lower expression of igf3,amh,insl3,hsd17b3,hsd11b2,hsd20b,cyp11b and cyp17 was consistently observed in the sst4−/−testis.In contrast,the ovaries had lower expression of igf1,igf2a and cyp19a1a but increased expression of igf2b and hsd20b.The gonadotrophin beta subunits(fshb and lhb)in the brain were downregulated indicating the brain-pituitary-gonadal axis was downregulated in the sst4−/−fish and suggesting that the steroid production is compromised in the maturing gonads.In addition,analysis of sst1 and sst3 mRNA levels in sst4−/−fish suggests a dosage compensation effect of sst1 in the brain and liver.Altogether,the results from the zebrafish sst4−/−line support the idea that sst4 is involved in the regulation of igf signalling,somatic growth and reproduction since steroidogenesis and gametogenesis at pubertal onset were compromised. | Chenchao Sui Jie Chen Jing Ma Wenting Zhao Adelino V.M.Canário Rute S.T.Martins | 2019 | Aquaculture and Fisheries2019，4，6： | 1 |
| 9 | Assessing estuarine quality under the ecosystem services scope: Ecological and socioeconomic aspects 显示文摘 | Rute Pinto Joana Patricio | 2010 | Ecological Complexity2010，7，3： | 1 |
| 10 | 'My land, your social transforma- tion': Conflicts within The landless people movement ( MST), Rio de Janeiro, Brazil 显示文摘 | Rute Caldeira 2005 | 2005 | Journal of Rural Stud- ies2005，，： | 1 |
| 11 | Effects of homocysteine on intracellular nitric oxide and superoxide levels in the renal arterial endothe lium显示文摘 | Li N Yi FX Rute E | 2002 | Am J Physiol Heart Circ Physiol2002，283，： | 1 |
| 12 | Influence of Total Intravenous Anesthesia, Entropy and Laparoscopy on Oxidative Stress显示文摘 | Rogean Rodrigues Nunes Fernando Squeff Nora Danielle Maia Holanda Dumaresq Rute Maria Araújo Cavalcante Amanda Antunes Costa Lara Moreira Mendes Carneiro Julio Cesar Garcia de Alencar Flávia Pereira Fernandes Cardoso | 2012 | Brazilian Journal of Anesthesiology2012，，4： | 1 |
| 13 | Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives显示文摘 | Ailton Melo Larissa Monteiro Rute M. F. Lima Diêgo M. de Oliveira Martins D. de Cerqueira Ramon S. El-Bachá Donatella Pietraforte | 2011 | Oxidative Medicine and Cellular Longevity2011，，： | 1 |
| 14 | biocatalytic transformations in ionic liquids显示文摘 | Fred van Rantwijk Rute Madeira Lau | 2003 | Trends in Biotechnology2003，21，3： | 1 |
| 15 | VZ05 nanowires with an intrinsic peroxidase-like activity显示文摘 | Rute Andre Filipe Natalio Madalena Humanes | 2011 | Adv Funct Mater2011，21，3： | 1 |
| 16 | Confirmation of STAT4, IL2/IL21, and CTLA-4 polymorphisms in rheumatoid arthritis显示文摘 | Nina AD Fina ASK Rute BM | 2009 | Arthritis Rheumatol2009，60，5： | 1 |
| 17 | Epilepsia partialis continua of the abdominal muscles due to cerebrovascular disease显示文摘 | Joana Jesus Ribeiro Mário Sousa Rute Teotónio Concei??o Bento Francisco Sales | 2015 | Epileptic Disorders2015，，： | 1 |
| 18 | School drop-out and push-out factors in Brazil: The role of early parenthood, child labor, and poverty 显示文摘 | Ana Rute Cardoso and Dorte Verner (2007 03) | 2007 | World Bank2007，，： | 1 |
| 19 | Wage Mobility: Do Institutions Make A Difference? 显示文摘 | Ana Rute Cardoso | 2006 | Labour Economics2006，13，3： | 1 |
| 20 | Ant colonyoptimization based sensor deployment protocol for wireless sensornetworks 显示文摘 | LIAO WENHWA KAO YUCHENG WU RUTING | 2011 | Expert Systems with Applications2011，38，6： | 1 |
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