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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 3 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 4 | Computer-aided morphometry of liver inflammation in needle biopsies显示文摘AIM: To introduce a computer-aided morphometric method for quantifying the necro-inflammatory phase in liver biopsy specimens using fractal geometry and Delaunay's triangulation.METHODS: Two-micrometer thick biopsy sections taken from 78 chronic hepatitis C virus-infected patients were immunohistochemically treated to identify the inflammatory cells. An automatic computer-aided image analysis system was used to define the inflammatory cell network defined on the basis of Delaunay's triangulation,and the inflammatory cells were geometrically classified as forming a cluster (an aggregation of a minimum of three cells) or as being irregularly distributed within the tissue. The phase of inflammatory activity was estimated using Hurst's exponent.RESULTS: The proposed automatic method was rapid and objective. It could not only provide rigorous results expressed by scalar numbers, but also allow the state of the whole organ to be represented by Hurst's exponent with an error of no more than 12%.CONCLUSION: The availability of rigorous metrical measures and the reasonable representativeness of the status of the organ as a whole raise the question as to whether the indication for hepatic biopsy should be revised by establishing clear rules concerning the contraindications suggested by its invasiveness and subjective interpretation. | N Dioguardi B Franceschini C Russo F Grizzi | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 5 | miRNAs and iscbemic heart disease:towards a better comprehension of pathogenesis,new diagnostic tools and new therapeutic targets显示文摘 | Silvestri P Di Russo C Rigattieri S | 2009 | Recent Pat Cardiovasc Drag Discov2009，4，： | 1 |
| 6 | Influence of wavelength on fractionation in laser ablation ICP-MS 显示文摘 | Russo R E Mao X L Borisov 0 V Liu H C | 2000 | Journal of Analytical Atomic Spectrometry2000，15，： | 1 |
| 7 | Curcumin blocks cytokinemediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity显示文摘 | Jobin C Bradham CA Russo MP | 1999 | J Immunol1999，163，6： | 1 |
| 8 | Palmitoylethanolamideprotects against the amyloid-β25-35-induced learning and memoryimpairment in mice, an experimental model of Alzheimerdisease显示文摘 | D'Agostino G Russo R Avagliano C | 2012 | Neuropsychopharmacology2012，37，7： | 1 |
| 9 | Neuroprotection by leptin in a rat model of permanent cerebral ischemia:effects on STAT3 phosphorylation in discrete cells of the brain显示文摘 | Amantea D Tassorelli C Russo R | 2011 | Cell Death Dis2011，，2： | 1 |
| 10 | Constitutive nuclear factor-κB activity is required for central neuron survival 显示文摘 | Bhakar AL Tannis LL Zeindler C Russo MP Jobin C Park DS | 2002 | J Neurosci2002，22，19： | 1 |
| 11 | Crystal structure of an HSP90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent 显示文摘 | Stebbins CE Russo AA Schneider C | 1997 | Cell1997，89，2： | 1 |
| 12 | Comparison of echocardiograph- ic single-plane versus biplane method in the assessment of left atrial volume and validation by real time three-dimensional e- chocardiography 显示文摘 | Russo C Hahn RT Jin Z | 2010 | J Am Soc Echocardiogr2010，23，9： | 1 |
| 13 | Ammonia toxicity to fishes effect of pH on the toxicity of the toxicity of the un-ionized ammonia species 显示文摘 | THURSTON R RUSSO R C VINOGRADOV G A | 1981 | Environment Science Technology1981，，15： | 1 |
| 14 | Expression of MAGE gene family in primary and metastatic human breast cancer: implications for tumor antigen specific immunotherapy显示文摘 | Russo V Traversari C Verrecchia A | | 0，，： | 1 |
| 15 | Long-term functional evaluation of the treated kidney in a prospective series of patients who underwent laparoscopic partial nephreetomy for small renal tumors显示文摘 | Porpiglia F Fiori C Bertolo R Morra I Russo R Pic- coli G | 2012 | Eur Urol2012，62，： | 1 |
| 16 | Maedi-visna virus infection in sheep,a review显示文摘 | Pepin M Vitu C Russo P | 1998 | Vet Res1998，29，34： | 1 |
| 17 | Impact of an electronic cigarette on smoking reduction and cessation in schizophrenic smokers:a prospective 12-month pilot study显示文摘 | Caponnetto P Auditor R Russo C | | 0，，： | 1 |
| 18 | Mucin gene expression in human male urogenital tract epithelia 显示文摘 | Russo C L Spurr-Michaud S Tisdale A | 2006 | Human Reprod2006，21，11： | 1 |
| 19 | Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent显示文摘 | Russo AA Schneider C | 1997 | Cell1997，89，2： | 1 |
| 20 | Filament conduction and reset mechanism in NiO-based resistive-switching memory(RRAM)devices显示文摘 | Russo U Ielmini D Cagli C | 2009 | IEEE Transactions Electron Devices2009，56，2： | 1 |
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