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| 1 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 2 | A new method for strengthening gold显示文摘 | Russell A Kai Xu Chumbley S | 1998 | Gold Bulletin1998，31，3： | 1 |
| 3 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 4 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 5 | Replication checkpoint kinase Cdsl regulates Mus81 to preserve genome integrity during replication stress显示文摘 | Boddy MN Russell P | 2005 | Genes Dev2005，19，8： | 1 |
| 6 | Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)显示文摘Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role in maintaining the homeostasis of gut epithelium.In 2009,Sato et al established a three-dimensional culture system,which mimicked the niche microenvironment by employing the niche factors,and successfully grew crypt ISCs into organoids or Mini-guts in vitro.Since then,the intestinal organoid technology has been used to delineate cellular signaling in ISC biology.However,the cultured organoids consist of heterogeneous cell populations,and it was technically challenging to introduce genomic changes into three-dimensional organoids.Thus,there was a technical necessity to develop a twodimensional ISC culture system for effective genomic manipulations.In this study,we established a conditionally immortalized mouse intestinal crypt(ciMIC)cell line by using a piggyBac transposon-based SV40 T antigen expression system.We showed that the ciMICs maintained long-term proliferative activity under two-dimensional niche factor-containing culture condition,retained the biological characteristics of intestinal epithelial stem cells,and could form intestinal organoids in three-dimensional culture.While in vivo cell implantation tests indicated that the ciMICs were non-tumorigenic,the ciMICs overexpressing oncogenic b-catenin and/or KRAS exhibited high proliferative activity and developed intestinal adenoma-like pathological features in vivo.Collectively,these findings strongly suggested that the engineered ciMICs should be used as a valuable tool cell line to dissect the genetic and/or epigenetic underpinnings of intestinal tumorigenesis. | Xiaoxing Wu Zhaoxia Li Hongyu Zhang Fang He Min Qiao Huaxiu Luo Jing Zhang Meng Zhang Yukun Mao William Wagstaff Yongtao Zhang Changchun Niu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Rex C.Haydon Russell R.Reid Hue H.Luu Tong-Chuan He Ziwei Wang Houjie Liang Bing-Qiang Zhang Ning Wang | 2021 | Genes & Diseases2021，8，6： | 1 |
| 7 | Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)显示文摘As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic lineages.It’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of MSCs.However,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly understood.Emerging evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone formation.As highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA biogenesis.Here,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of MSCs.We first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in MSCs.By engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in MSCs.Furthermore,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone formation.Collectively,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs. | Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker Connie Chen Russell R.Reid Rex C.Haydon Sherwin H.Ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu | 2021 | Genes & Diseases2021，8，6： | 1 |
| 8 | 膝关节软骨缺损的微骨折软骨面重建 手术技术显示文摘背景:微骨折是常用于修复膝关节软骨病损的技术。尽管该项技术应用很普遍,但有关远期临床结果的信息仍很有限。本研究的目的是找出该项软骨修复技术临床疗效的影响因素。
方法:采用微骨折技术治疗48例膝关节稳定、股骨髁孤立、全层软骨缺损并有症状的患者。最短随访24个月,采用公认的疗效评分和主观临床评级及软骨敏感NRI扫描对患者的结果进行前瞻性评估。
结果:末次随访时,膝关节功能优、良32例(67%),可12例(25%),差4例(8%)。日常活动评分、国际膝关节信息委员会(IKDC)评分、SF-36体格检查评分术后均有显著性增加(p〈0.05),体重指数(BM)较低,则日常活动评分SF-36体格检查评分较高,BMI〉30kg/m^2则效果最差。术前症状时间少于12个月,则日常活动评分显著增加(p〈0.05)。24膝中MRI证实缺损填充,修复良好13例(54%),中等填充7例(29%),填充不良4例(17%),填充度与膝关节功能评分相关。全部缺损填充良好的膝关节,功能均有改善,而填充不良的关节,功能改善有限,且24个月后功能评分下降。
结论:微骨折技术修复膝关节软骨病损在最短2年的随访期间功能有显著改善,软骨缺损填充良好,BMI较低,术前症状期短者可取得最佳短期疗效;高BMI对短期疗效有负面影响,软件缺损填充不良则短期疗效较差。 | KAI MITHOEFER RILEY J. WILLIAMS Ⅲ RUSSELL F. WARREN HOLLIS G. POTTER CHRISTOPHER R. SPOCK EDWARD C. JONES THOMAS L. WICKIEWICZ ROBERT G. MARX 张春礼(译) | 2007 | 骨科动态2007，3，1： | 0 |
| 9 | Corrigendum to ‘Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)’ [Genes Dis 8 (2021) 814-826]显示文摘The authors regret that an image assembly(copy/paste)error in Figure 3D,in which the image for the organoid of'Primary MiCs'group was erroneously duplicated with an image of primary MICs that was previously published.The corrected figure is shown below.As shown in the corrected Figure 3D,this error does not adversely impact the conclusion of the original work.The authors would like to apologise forany inconvenience caused. | Xiaoxing Wu Zhaoxia Li Hongyu Zhang Fang He Min Qiao Huaxiu Luo Jing Zhang Meng Zhang Yukun Mao William Wagstaff Yongtao Zhang Changchun Niu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Rex C. Haydon Russell R. Reid Hue H. Luu Tong-Chuan He Ziwei Wang Houjie Liang Bing-Qiang Zhang Ning Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 10 | 微骨折技术治疗膝关节软骨损伤——前瞻性分组研究显示文摘背景:微骨折技术常用于修复膝关节软骨损伤。虽然该技术目前已广泛应用,但有关临床疗效的前瞻性研究尚不多,本研究旨在分析骨修复技术影响临床结果的因素。
方法:48例关节稳定性正常、有症状的单发股骨髁全层软骨损伤患者采用微骨折技术进行治疗。术后随访至少24个月,采用公认的功能评分系统、主观评分及软骨敏感MRI扫描序列进行前瞻性评价。
结果:膝关节功能优良者32例(67%),可12例(25%),差4例(8%)。日常生活能力评分、国际膝关节论证委员会(Inter-national Knee Documentation Committee,IKDC)评分及SF-36评分均明显增加(p〈0.05)。身高体重指数小可以获得日常生活能力和SF-36的高评分,身高体重指数〉30kg/m^2者得分最差。术前病程短于12个月者可以明显改善日常生活能力评分(p〈0.05)。24例接受MR检查的病例显示13例(54%)软骨修复、充填好,7例(29%)充填中等,4例(17%)充填差。充填程度与膝关节功能评分密切相关。所有充填好的病例功能均有所改善,而充填差的病例不仅功能改善有限,而且24个月后出现功能评分降低。
结论:通过2年以上的随访证实,采用微骨折技术修复膝关节软骨损伤可以明显改善术后功能。软骨修复、充填好,身高体重指数小及术前病程短者可以获得最佳的短期疗效。身高体重指数大对短期疗效有负面影响,软骨修复、充填差的病例疗效维持时间短。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | KAI MITHOEFER RILEY J. WILLIAMS Ⅲ RUSSELL F. WARREN HOLLIS G. POTTER CHRISTOHER R. SPOCK EDWARD C. JONES THOMAS L. WICKIEWICZ ROBERT G. MARX 冯华(译) | 2006 | 骨科动态2006，2，1： | 0 |
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