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| 1 | Polarization-maintaining few mode fiber composed of a central circular-hole and an elliptical-ring core显示文摘We propose a novel waveguide design of polarization-maintaining few mode fiber(PM-FMF) supporting ≥10non-degenerate modes, utilizing a central circular air hole and a circumjacent elliptical-ring core. The structure endows a new degree of freedom to adjust the birefringence of all the guided modes, including the fundamental polarization mode. Numerical simulations demonstrate that, by optimizing the air hole and elliptical-ring core,a PM-FMF supporting 10 distinctive polarization modes has been achieved, and the effective index difference Δn_(eff) between the adjacent guided modes could be kept larger than 1.32 × 10^(-4) over the whole C +L band. The proposed fiber structure can flexibly tailored to support an even larger number of modes in PM-FMF(14-mode PM-FMF has been demonstrated as an example), which can be readily applicable to a scalable mode division multiplexing system. | JIAJIA ZHAO MING TANG KYUNGHWAN OH ZHENHUA FENG CAN ZHAO RUOLIN LIAO SONGNIAN FU PERRY PING SHUM DEMING LIU | 2017 | Photonics Research2017，5，3： | 9 |
| 2 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 3 | Automatic Modulation Recognition Based on CNN and GRU显示文摘Based on a comparative analysis of the Long Short-Term Memory(LSTM)and Gated Recurrent Unit(GRU)networks,we optimize the structure of the GRU network and propose a new modulation recognition method based on feature extraction and a deep learning algorithm.High-order cumulant,Signal-to-Noise Ratio(SNR),instantaneous feature,and the cyclic spectrum of signals are extracted firstly,and then input into the Convolutional Neural Network(CNN)and the parallel network of GRU for recognition.Eight modulation modes of communication signals are recognized automatically.Simulation results show that the proposed method can achieve high recognition rate at low SNR. | Fugang Liu Ziwei Zhang Ruolin Zhou | 2022 | Tsinghua Science and Technology2022，27，2： | 5 |
| 4 | Therapeutic effect of natural melanin from edible fungus Auricularia auricula on alcohol-induced liver damage in vitro and in vivo显示文摘This study explored the therapeutic effects of Auricularia auricula melanin(AAM)on alcoholic liver damage in vitro and in vivo.Human normal liver L02 cells were pre-treated with ethanol and then treated with AAM to explore the therapeutic effect of AAM on ethanol-induced hepatocyte injury.The results show that AAM signifi cantly elevated the cell viability,ameliorated the cell morphology,reduced the ROS and increased the GSH/GSSG of ethanol-pretreated L02 cells.Then,mice were administered with ethanol to induce acute alcoholic liver damage,and administered with AAM to further study the therapeutic effect of AAM on alcoholic liver damage in mice.As a result,AAM reduced the levels of ALT,AST,TG,and MDA,increased the levels of ADH,SOD,and CAT in liver damage mice.The therapeutic effect of AAM may be related to inhibition of CYP2E1 expression and activation of Nrf2 and its downstream antioxidase.The research enriched the bioactivity of AAM and provided some ideas for the development of melanin-related health foods. | Ruolin Hou Xin Liu Xiaoping Wu Mingfeng Zheng Junsheng Fu | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 5 | Enhanced remediation of Cr(Ⅵ)-contaminated groundwater by coupling electrokinetics with ZVI/Fe_(3)O_(4)/AC-based permeable reactive barrier显示文摘Although widely used in permeation reaction barrier(PRB)for strengthening the removal of various heavy metals,zero-valent iron(ZVI)is limited by various inherent drawbacks,such as easy passivation and poor electron transfer.As a solution,a synergistic system with PRB and electrokinetics(PRB-EK)was established and applied for the efficient removal of Cr(Ⅵ)-contaminated groundwater.As the filling material of PRB,ZVI/Fe_(3)O_(4)/activated carbon(ZVI/Fe_(3)O_(4)/AC)composites were synthesized by ball milling and thermal treatment.A series of continuous flow column experiments and batch tests was conducted to evaluate the removal efficiency of Cr(Ⅵ).Results showed that the removal efficiency of Cr(Ⅵ)remained above 93%even when the bed volume(BV)reached 2000 under the operational parameters(iron/AC mass ratio,2:1;current,5 m A).The mechanism of Cr(Ⅵ)removal by the PRB-EK system was revealed through field emission scanning electron microscopy images,X-ray diffraction,X-ray photoelectron spectroscopy,Fe^(2+) concentration,and redox potential(E h)values.The key in Cr(Ⅵ)reduction was the Fe^(2+)/Fe^(3+) cycle driven by the surface microelectrolysis of the composites.The application of an externally supplied weak direct current maintained the redox process by enhancing the electron transfer capability of the system,thereby prolonging the column lifetime.Cr(Ⅵ)chemical speciation was determined through sequential extraction,verifying the stability and safety of the system.These findings provide a scientific basis for PRB design and the in-situ remediation of Cr(Ⅵ)-contaminated groundwater. | Ruolin Cao Shiqing Liu Xinyu Yang Chunfeng Wang Yanbin Wang Wanfeng Wang Yunqing Pi | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 6 | Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold显示文摘Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis,and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time.Presently,there is insufficient data on the biological and mechanical responses of blood vessels accompanied by bioresorbable scaffolds(BRS)degradation.Therefore,it is necessary to investigate the inflexion point of degradation,the response of blood vessels,and the pathophysiological process of vascular,as results of such studies will be of great value for the design of next generation of BRS.In this study,abdominal aortas of SD rats were received 3-D printed poly-l-actide vascular scaffolds(PLS)for various durations up to 12 months.The response of PLS implanted aorta went through two distinct processes:(1)the neointima with desirable barrier function was obtained in 1 month,accompanied with slow degradation,inflammation,and intimal hyperplasia;(2)significant degradation occurred from 6 months,accompanied with decreasing inflammation and intimal hyperplasia,while the extracellular matrix recovered to normal vessels which indicate the positive remodeling.These in vivo results indicate that 6 months is a key turning point.This“two-stage degradation and vascular characteristics”is proposed to elucidate the long-term effects of PLS on vascular repair and demonstrated the potential of PLS in promoting endothelium function and positive remodeling,which highlights the benefits of PLS and shed some light in the future researches,such as drug combination coatings design. | Tieying Yin Ruolin Du Yang Wang Junyang Huang Shuang Ge Yuhua Huang Youhua Tan Qing Liu Zhong Chen Hanqing Feng Jie Du Yazhou Wang Guixue Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 7 | Assessing oil spill risk in the Chinese Bohai Sea:A case study for both ship and platform related oil spills 显示文摘 | Liu Xin Meng Ruolin Xing Qianguo | 2015 | Ocean and Coastal Management2015，108，： | 1 |
| 8 | Genome Size Evolution Mediated by Gypsy Retrotransposons in Brassicaceae显示文摘The dynamic activity of transposable elements(TEs)contributes to the vast diversity of genome size and architecture among plants.Here,we examined the genomic distribution and transposition activity of long terminal repeat retrotransposons(LTR-RTs)in Arabidopsis thaliana(Ath)and three of its relatives,Arabidopsis lyrata(Aly),Eutrema salsugineum(Esa),and Schrenkiella parvula(Spa),in Brassicaceae.Our analyses revealed the distinct evolutionary dynamics of Gypsy retrotransposons,which reflects the different patterns of genome size changes of the four species over the past million years.The rate of Gypsy transposition in Aly is approximately five times more rapid than that of Ath and Esa,suggesting an expanding Aly genome.Gypsy insertions in Esa are strictly confined to pericentromeric heterochromatin and associated with dramatic centromere expansion.In contrast,Gypsy insertions in Spa have been largely suppressed over the last million years,likely as a result of a combination of an inherent molecular mechanism of preferential DNA removal and purifying selection at Gypsy elements.Additionally,species-specific clades of Gypsy elements shaped the distinct genome architectures of Aly and Esa. | Shi-Jian Zhang Lei Liu Ruolin Yang Xiangfeng Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 1 |
| 9 | The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation显示文摘In recent years,cardiovascular health problems are becoming more and more serious.At the same time,mechanical stimulation closely relates to cardiovascular health.In this context,Piezo1,which is very sensitive to mechanical stimulation,has attracted our attention.Here,we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells,NO production,lipid metabolism,DNA damage protection,the development of new blood vessels and maturation,narrowing of blood vessels,blood pressure regulation,vascular permeability,insulin sensitivity,and maintenance of red blood cell function.Besides,Piezo1 may participate in the occurrence and development of atherosclerosis,diabetes,hypertension,and other cardiovascular diseases.It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health.On the one hand,the function of Piezo1 is necessary to maintain cardiovascular health;on the other hand,under some extreme mechanical stimulation,the overexpression of Piezo1 may bring adverse factors such as inflammation.Therefore,this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1. | Junyang Huang Kun Zhang Ruolin Du Wanling Liu Haijun Zhang Tian Tian Yazhou Wang Guixue Wang Tieying Yin | 2023 | Genes & Diseases2023，10，5： | 1 |
| 10 | Micro/nanoelectrode-based electrochemical methodology for single cell and organelle analysis显示文摘Cells are the basic unit of life.Electrochemical analysis of single cells/organelles is essential for uncovering the molecular mechanisms of physiological and pathological processes that are difficult to elucidate on a larger scale.This paper provides an overview of the commonly used fabrication methods for micro/nanoelectrodes applied in the investigations of single cells/organelles as well as the corresponding electrochemical measurements over the last four years including extracellular measurement,combination of extra and intracellular measurement,intracellular reactive oxygen species and reactive nitrogen species(ROS/RNS)measurement,and isolated organelles measurement. | Chuchu Xu De Yang Yuchan Wang Ruolin Liu Fan Wang Zhongqun Tian Keke Hu | 2024 | Nano Research2024，17，1： | 0 |
| 11 | Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm(Bombyx mori)显示文摘Metamorphosis is a complex developmental process involving multiple pathways and a large number of genes that are regulated by juvenile hormone(JH)and 20-hydroxyecdysone(20E).Despite important progress in understanding various aspects of silkworm biology,the hormone signaling pathway in the silkworm remains poorly understood.Genome-wide screening using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-based libraries has recently emerged as a novel method for analyzing genome function,enabling further research into essential genes,drug targets,and virus-host interaction.Previously,we constructed a genome-wide CRISPR/Cas9-based library of the silkworm(Bombyx mori)and successfully revealed the genes involved in biotic or abiotic stress factor responses.In this study,we used our silkworm CRISPR library and large-scale genome-wide screening to analyze the key genes in the silkworm 20E signaling pathway and their mechanisms of action.Functional annotation showed that 20E regulates key proteins in processes that mainly occur in the cytoplasm and nucleus.Pathway enrichment analysis showed that 20E can activate phosphorylation and may affect innate immunity,interfere with intracellular nutrition and energy metabolism,and eventually cause cell apoptosis.The screening results were experimentally validated by generating cells with knockout alleles of the relevant genes,which had increased tolerance to 20E.Our findings provide a panoramic overview of signaling in response to 20E in the silkworm,underscoring the utility of genome-wide CRISPR mutant libraries in deciphering hormone signaling pathways and the mechanisms that regulate metamorphosis in insects. | Hao Sun Jingya Chen Ruolin Wang Dan Liu Na Zhang Tong Zhang Ling Jia Sanyuan Ma Qingyou Xia | 2024 | Insect Science2024，31，1： | 0 |
| 12 | Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain显示文摘Soluble epoxide hydrolase(sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained using our previous reported compound 4 as lead compound. A preferential modification of piperidinyl to 3-carbamoyl piperidinyl was identified for this series via structure-based rational drug design. Compound A20 exhibited moderate percentage plasma protein binding(88.6%) and better metabolic stability in vitro. After oral administration, the bioavailability of A20 was 28.6%. Acute toxicity test showed that A20 was well tolerated and there was no adverse event encountered at dose of 6.0 g/kg. Inhibitor A20 also displayed robust analgesic effect in vivo and dose-dependently attenuated neuropathic pain in rat model induced by spared nerve injury, which was better than gabapentin and sEH inhibitor(±)-EC-5026. In one word, the oral administration of A20 significantly alleviated pain and improved the health status of the rats, demonstrating that A20 was a promising candidate to be further evaluated for the treatment of neuropathic pain. | Fangyu Du Ruolin Cao Lu Chen Jianwen Sun Yajie Shi Yang Fu Bruce D.Hammock Zhonghui Zheng Zhongbo Liu Guoliang Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
| 13 | Occurrence and Health Risk of Perfluoroalkyl Acids in Popular Shellfish from a Typical Coastal Area of the East China显示文摘As crucial homologous members of per-and polyfluoroalkyl substances(PFASs),perfluoroalkyl acids(PFAAs)have aroused wide public concern because of their unique properties(persistence,bioaccumulation,long-distance migration and toxicity).Studies have shown their potential hazard to wildlife and humans,with food consumption as one of the primary routes of PFAA exposure for general population,especially seafood intake.In this study,17 PFAAs were quantified in 9 shellfish species from Yuhuan City,a typical coastal area of the East China.The total mean concentrations of PFAAs were in the range of 5.03–381 ng/g dry weight(dw),with the highest concentration found in Neverita didyma and the lowest in Babylonia lutosa.Concentrations and composition profiles of PFAAs varied significantly among different species,indicating differences in the bioaccumulation potential of PFAAs among species.Perfluorooctanoic acid(PFOA)was presented as the most abundant PFAA in this study,followed by perfluorobutanoic acid(PFBA).Significant positive correlations were observed among some individual PFAAs(p<0.05),indicating that they may share similar pollution sources or undergo similar compound behaviors.Health risk assessment indicated a relatively high threat for local residents exposed to PFAAs through shellfish consumption. | LIU Ruolin LIU Mei ZHAO Chuxuan FU Jianjie ZHOU Wei ZHANG Qinghua Martin HANSEN DONG Yin | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 14 | Risk factors associated with the progression from mild keloids to severe keloids显示文摘Background:Keloids are benign fibrous growths that are caused by excessive tissue build-up.Severe keloids exert more significant effects on patients’quality of life than do mild keloids.We aimed to identify factors associated with the progression from mild keloids to severe keloids,as distinct from those associated with the formation of keloids.Methods:In this retrospective case-control study,251 patients diagnosed with keloids at West China Hospital between November 2018 and April 2021 were grouped according to the severity of lesions(mild[n=162]or severe[n=89]).We collected their basic characteristics,living habits,incomes,comorbidities,and keloid characteristics from Electronic Medical Records in the hospital and the patients’interviews.Conditional multivariable regression was performed to identify the independent risk factors for the progression of keloids.Results:Eighty-nine patients(35.5%)were classified as having severe keloids.We found the distribution of severe keloids varied with sex,age,excessive scrubbing of keloids,family income,the comorbidity of rheumatism,disease duration,characteristics of the location,location in sites of high-stretch tension,the severity and frequency of pain,the severity of pruritus,and infection.Multivariable analysis revealed significant associations between severe keloids and infection(odds ratio[OR],3.55;P=0.005),excessive scrubbing of keloids(OR,8.65;P=0.001),low or middle family income(OR,13.44;P=0.021),comorbidity of rheumatism(OR,18.97;P=0.021),multiple keloids located at multiple sites(OR,3.18;P=0.033),and disease duration>15 years(OR,2.98;P=0.046).Conclusion:Doctors should implement more active and thorough measures to minimize the progression of mild keloids in patients who have any of the following risk factors:infection,excessive scrubbing of keloids,low or middle family income,comorbidity of rheumatism,multiple keloids located at multiple sites,and disease duration>15 years. | Ruolin Liu Haitao Xiao Ru Wang Wei Li Ke Deng Ying Cen Xuewen Xu | 2022 | Chinese Medical Journal2022，，7： | 0 |
| 15 | Efficient Contact between H_(2)O and N-Coordinate Ru Nanoparticles in Three-Dimensionally Ordered Macro/Mesoporous Carbon Boosting Alkaline HER显示文摘In this study,a novel approach is proposed to achieve the uniformly dispersed Ru nanoparticles with N coordination loaded on three-dimensionally ordered macro/mesoporous carbon(3DOMMC)through simultaneous pyrolysis of Ru^(3+)and cyanamide on 33DOMMC.In an alkaline medium,the synthesized catalysts exhibit exceptional hydrogen evolution reaction(HER)performance.Specificall,Ru-N/3DOMMC demonstrates a significantly low overpotential of 13.8 mV to achieve acrent density of 10 mA.cmzandit exhibits a mass activity 17.5 times higher than that of commercial Pt/C.The outstanding performance could be attributed to the ultrahigh Ru dispersion and more efficient contact between active sites and reactant,which derived from the large specific surface area and interconnective three-dimensionally macro/mesopores of 3DOMMC. | Jiaqing Luo Chunyu Liu Ruolin Zhang Yuanqing Sun Hua Xu Qingying Hu Manxue Zhang Jun Li Zhenxing Li Weiyu Song Yuechang Wei Jian Liu | 2024 | Chinese Journal of Chemistry2024，42，2： | 0 |
| 16 | Isotopic fingerprinting of dissolved iron sources in the deep western Pacific since the late Miocene显示文摘Iron(Fe)is a productivity-limiting nutrient in the ocean.However,the sources of dissolved Fe(dFe)in the deep ocean and how they respond to tectonic and climate changes are still poorly understood.In the northern hemisphere,dust flux to the low-latitude western Pacific has increased dramatically since the late Miocene associated with intense aridification of the Asian inland.Meanwhile,the terrigenous material supply to the open ocean might have also changed as a result of the reorganization of the Pacific circulation due to the gradual closure of seaways in the low latitudes.Therefore,the western Pacific is a characteristic region for understanding the sources of dFe in the deep ocean and their responses to long term climate changes.Here,we present data on isotopic evolution of dFe and dissolved Pb since^8 Ma based on ferromanganese crust METG-03(16.0°N,152.0°E,3850 m water depth)in the western Pacific deep water.Our results show thatδ56Fe of the crust remains fairly stable since the late Miocene,i.e.,about-0.32±0.08‰(2SD).We infer thatδ56Fe of dFe in the deep western Pacific is relatively invariant at^0.45±0.1‰based on the Fe isotopic fractionation between hydrogenetic crust and the seawater dissolved component.The reconstructed isotope signature is similar to the measuredδ56Fe value(0.37±0.15‰)of the intermediate to deep waters in the modern low-latitude western Pacific region close to the island arcs,but is significantly higher than that of the eastern Pacific deep waters near South America which is controlled by the reductive dissolution of continental shelf sediments and the hydrothermal inputs(δ56Fe<-0.1‰).The deep-water 206Pb/204Pb ratio recorded by METG-03 displays systematic increase at about 8–4 Ma,reflecting increased input from sediment dissolution of low-latitude island arcs associated with reorganization of the western Pacific deep circulation.Notably,Fe isotopes of terrigenous materials from different sources are similar,while their dissolved Fe isotopic signatures released to the ocean are mainly controlled by the mechanism of particle dissolution.The stability ofδ56Fe and systematic changes in Pb isotopes over the last^8 Ma thus suggest that Asian dust dissolution and hydrothermal inputs are likely only minor sources of dFe in the low-latitude deep western Pacific,while the acquisition and transport of dFe from shelf sediments by organic ligand binding in the oxic environment is the major dFe source which keeps stable on tectonic time scales since the late Miocene. | Ruolin LIU Bai GUO Maoyu WANG Weiqiang LI Tao YANG Hongfei LING Tianyu CHEN | 2020 | Science China Earth Sciences2020，63，11： | 0 |
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