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| 1 | OVERVIEW OF SEVERE TYPHOON FITOW AND ITS OPERATIONAL FORECASTS显示文摘Severe typhoon Fitow(1323)brought persistent and heavy rainfall to Zhejiang and the Shanghai area after it made landfall at Fujian Province of China in October 2013,breaking the rainfall records of several counties and districts in Zhejiang.In this paper,we provide an overview of the characteristics of Fitow’s landfall,including its track,intensity,structural evolution,heavy rainfall,and wind.We also describe some of the associated disastrous impacts.Finally,we provide verifications of operational forecasts of its track,intensity and rainfall.Though the track and intensity is well predicted,the rainfall persistence and enhancement in the second stage in Shanghai and north Zhejiang areas are not predicted out at all.The analysis presented in this paper provides forecasters and researchers with some valuable information on Fitow,which could form a useful basis for further studies. | ZIFENG YU YANDIE CHEN DAN WU GUOMIN CHEN XUWEI BAO QIUZHEN YANG RUNLING YU LEI ZHANG JIE TANG MING XU ZHIHUA ZENG | 2014 | Tropical Cyclone Research and Review2014，3，1： | 2 |
| 2 | Adenosine triphosphate-sensitive potassium channel opener protects PC12 cells against hypoxia-induced apoptosis through PI3K/Akt and Bcl-2 signaling pathways显示文摘Although previous studies have shown the neuroprotective effects of the adenosine triphosphate(ATP)-sensitive potassium(KATP) channel opener against ischemic neuronal damage,little is known about the mechanisms involved.Phosphatidylinositol-3 kinase(PI3K)/v-akt murine thy-moma viral oncogene homolog(Akt) and Bcl-2 are thought to be important factors that mediate neuroprotection.The present study investigated the effects of KATP openers on hypoxia-induced PC12 cell apoptosis,as well as mRNA and protein expression of Akt and Bcl-2.Results demon-strated that pretreatment of PC12 cells with pinacidil,a KATP opener,resulted in decreased PC12 cell apoptosis following hypoxia,as detected by Annexin-V fluorescein isothiocyanate/propidium iodide double staining flow cytometry.In addition,mRNA and protein expression of phosphory-lated Akt(p-Akt) and Bcl-2 increased,as detected by immunofluorescence,Western blot analysis,and reverse-transcription polymerase chain reaction.The protective effect of this preconditioning was attenuated by glipizide,a selective KATP blocker.These results demonstrate for the first time that the protective mechanisms of KATP openers on PC12 cell apoptosis following hypoxia could result from activation of the PI3K/Akt signaling pathway,which further activates expression of the downstream Bcl-2 gene. | Hong Zhang Chunhong Jia Danyang Zhao Yang Lu Runling Wang Jia Li | 2010 | Neural Regeneration Research2010，5，22： | 1 |
| 3 | Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis显示文摘Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001. | Nazi Song Hongjiao Xu Jiahua Liu Qian Zhao Hui Chen Zhibin Yan Runling Yang Zhiteng Luo Qi Liu Jianmei Ouyang Shuohan Wu Suijia Luo Shuyin Ye Runfeng Lin Xi Sun Junqiu Xie Tian Lan Zhongdao Wu Rui Wang Xianxing Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
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