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| 1 | Recent developments in high-strength Mg-RE-based alloys:Focusing on Mg-Gd and Mg-Y systems显示文摘Higher strength is always the goal pursued by researchers for the structural materials,especially for the lightweight magnesium(Mg)alloys which generally have relatively low strength at present.From this aspect,the present paper reviews the recent reports of a kind of Mg alloys,i.e.Mg-RE(RE:rare earths,mainly Gd or Y)casting and wrought alloys,which have been able to achieve high strength compared with common or commercial Mg alloys,from the viewpoint and content of the alloy system,alloying constitution,preparation process,tensile strength and each of the main strengthening mechanisms.This review of recent research and developments in high-strength Mg-RE alloys is beneficial for the further design of Mg alloys with higher strength as well as excellent comprehensive performance. | Jinghuai Zhang Shujuan Liu Ruizhi Wu Legan Hou Milin Zhang | 2018 | Journal of Magnesium and Alloys2018，6，3： | 60 |
| 2 | Towards developing Mg alloys with simultaneously improved strength and corrosion resistance via RE alloying显示文摘Magnesium(Mg)alloys have received an increasing interest in the past two decades for their tremendous application potential.The strength and corrosion resistance levels of common Mg alloys are still relativity low,and especially they are to be improved simultaneously.The addition of rare earth(RE)to Mg alloys is believed to be beneficial for both the strength and corrosion resistance,and some RE-modified traditional Mg alloys have been studied and some new RE-containing Mg alloys have been developed by now.However,further simultaneous improvements in both strength and anti-corrosion require a better understanding of the behavior and mechanism of RE in Mg alloys.In this review,the common influence mechanisms of RE on mechanical and anti-corrosion properties of Mg alloys are summarized,and the latest research progress of RE-containing Mg alloys with simultaneously improved strength and corrosion resistance are introduced.It is demonstrated that the research on high-strength and high corrosion resistant RE-containing Mg alloys is still immature,and some opinions and suggestions are put forward for the synergetic improvement of the strength and corrosion resistance of Mg alloys,so as to contribute to the further development of Mg alloys with higher performance. | Jinshu Xie Jinghuai Zhang Zihao You Shujuan Liu Kai Guan Ruizhi Wu Jun Wang Jing Feng | 2021 | Journal of Magnesium and Alloys2021，9，1： | 25 |
| 3 | Promotive Effects of Alginate-Derived Oligosaccharides on the Inducing Drought Resistance of Tomato显示文摘In order to determine the role of alginate-derived oligosaccharides (ADO) in drought stress resistance of tomato (Ly-copersicon esculentum Miller) seedlings, the leaves were exposed to different concentrations of ADO (0.05%, 0.10%, 0.20%, 0.30% and 0.50%) after drought stress was simulated by exposing the roots to 0.6 molL-1 PEG-6000 solution for 6 h. Changes in biomass, electrolyte leakage and malondialdehyde (MDA), free proline, total soluble sugars (TSS) and abscisic acid (ABA), the enzyme activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) were measured to investigate the effects of ADO treatment. The results showed that the treatment with an ADO concentration of 0.20% exhibited the highest performance of drought stress resistance in the tomato seedlings by decreasing the electrolyte leakage and the concentration of MDA, increasing the contents of free proline, TSS and ABA, and increasing the activities of CAT, SOD, POD and PAL after treatment with ADO. It is suggested that changes in electrolyte leakage, MDA, osmotic solutes, ABA, anti-oxidative enzyme and PAL activities were responsible for the increased drought stress resistance in tomato seedlings. To our best knowledge, this is the first report of the effect of ADO treatment on enhancing the drought stress resistance of tomato seedlings. | LIU Ruizhi JIANG Xiaolu GUAN Huashi LI Xiaoxia DU Yishuai WANG Peng MOU Haijin | 2009 | Journal of Ocean University of China2009，8，3： | 16 |
| 4 | Dietary protocatechuic acid ameliorates inflammation and up-regulates intestinal tight junction proteins by modulating gut microbiota in LPS-challenged piglets显示文摘Background: Weaning is one of the major factors that cause stress and intestinal disease in piglets. Protocatechuic acid(PCA) is an active plant phenolic acid which exists in Chinese herb, Duzhong(Eucommia ulmoides Oliver), and is also considered as the main bioactive metabolite of polyphenol against oxidative stress and inflammation. This study aimed to investigate the effect of PCA on growth performance, intestinal barrier function, and gut microbiota in a weaned piglet model challenged with lipopolysaccharide(LPS).Methods: Thirty-six piglets(Pig Improvement Company line 337 × C48, 28 d of age, 8.87 kg ± 0.11 kg BW) were randomly allocated into 3 treatments and fed with a basal diet(CTL), a diet added 50 mg/kg of aureomycin(AUR), or a diet supplemented with 4000 mg/kg of PCA, respectively. The piglets were challenged with LPS(10 μg/kg BW) on d 14 and d 21 by intraperitoneal injection during the 21-d experiment. Animals(n = 6 from each group) were sacrificed after being anesthetized by sodium pentobarbital at 2 h after the last injection of LPS. The serum was collected for antioxidant indices and inflammatory cytokines analysis, the ileum was harvested for detecting mRNA and protein levels of tight junction proteins by PCR and immunohistochemical staining, and the cecum chyme was collected for intestinal flora analysis using 16 S rRNA gene sequencing.Results: Dietary supplementation of PCA or AUR significantly increased the expression of tight junction proteins including ZO-1 and claudin-1 in intestinal mucosa, and decreased the serum levels of thiobarbituric acid reactive substances(TBARS) and IL-6, as compared with CTL group. In addition, PCA also decreased the serum levels of IL-2 and TNF-α(P < 0.05). Analysis of gut microbiota indicated that PCA increased the Firmicutes/Bacteroidetes ratio(P < 0.05). Spearman's correlation analysis at the genus level revealed that PCA reduced the relative abundance of Prevotella 9, Prevotella 2, Holdemanella, and Ruminococcus torques group(P < 0.05), and increased the relative abundance of Roseburia and Desulfovibrio(P < 0.05), whereas AUR had no significant effect on these bacteria.Conclusions: These results demonstrated that both PCA and AUR had protective effect on oxidative stress, inflammation and intestinal barrier function in piglets challenged with LPS, and PCA potentially exerted the protective function by modulating intestinal flora in a way different from AUR. | Ruizhi Hu Ziyu He Ming Liu Jijun Tan Hongfu Zhang De-Xing Hou Jianhua He Shusong Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 12 |
| 5 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 6 | Construction of a macromolecular structural model of Chinese lignite and analysis of its low-temperature oxidation behavior显示文摘The aim of this paper is to analyze the change in the active structure of lignite during the process of lowtemperature oxidation by constructing a molecular structure model for lignite. Using quantum computation combined with experimental results of proximate analysis, ultimate analysis, Fourier transform infrared spectroscopy(FTIR) and X-ray photoelectron spectroscopy(XPS), a structural model for the large molecular structure was constructed. By analyzing the bond lengths in the model molecule, the evolution law for the active structure of lignite was predicted for the process of low-temperature oxidation. In low-temperature oxidation,alkanes and hydroxyls are the primary active structures observed in lignite, though ether may also react. These active functional groups react with oxygen to release heat, thereby speeding up the reaction between coal and oxygen. Finally, the content of various functional groups in the process of lignite low-temperature oxidation was analyzed by infrared analysis, and the accuracy of the model was verified. | Xianliang Meng Mingqiang Gao Ruizhi Chu Zhenyong Miao Guoguang Wu Lei Bai Peng Liu Yuanfang Yan Pengcheng Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 8 |
| 7 | Integrated biomarkers in wild crucian carp for early warning of water quality in Hun River, North China显示文摘Metabolizing enzymes play important roles in the detoxification of various pollutants in aquatic organisms, thereby they can also be used to provide early-warning signals of environmental risks. Real-time quantitative reverse-transcription polymerase chain reaction assays were developed to quantify cytochrome P450 1A(CYP1A), superoxide dismutase(SOD), glutathione peroxidase(GPx), catalase(CAT), and glutathione-S-transferase(GST) in crucian carp(Carassius auratus). The methods were then used to detect the respective mRNA expression levels in liver tissue in wild crucian carp from the Hun River, North China. CYP1A mRNA expression was significantly up-regulated in fish from stations S5, S6, and S8(p < 0.05). SOD mRNA expression was significantly down-regulated in downstream areas relative to fish from upstream sites(p < 0.05); GPx and CAT mRNA expression levels were also down-regulated at S9(p < 0.05). In contrast, GST mRNA expression showed no obvious change between fish collected from up- or downstream areas of the river. Finally, an integrated biomarker response was used to evaluate the integrated impact of pollutants in the Hun River and allow better comprehension of the real toxicological risk of these investigated sites. | Binghui Zheng Kun Lei Ruizhi Liu Shuangshuang Song Lihui An | 2014 | Journal of Environmental Sciences2014，26，4： | 6 |
| 8 | Development of extruded Mg-6Er-3Y-1.5Zn-0.4Mn(wt.%) alloy with high strength at elevated temperature显示文摘A new Mg-6 Er-3 Y-1.5 Zn-0.4 Mn(wt.%) alloy with high strength at high temperature was designed and extruded at 350℃. The as-extruded alloy exhibits ultimate tensile strength of 301 MPa, yield strength(along ED) of 274 MPa and thermal conductivity of 73 W/m·K at 300℃. Such outstanding hightemperature strength is mainly attributed to the formation of nano-spaced solute-segregated basal plane stacking faults(SFs) with a large aspect ratio throughout the entire Mg matrix, fine dynamically recrystallized(DRXed) grains of 1–2μm and strongly textured un-DRXed grains with numerous sub-structures.Microstructural examination unveils that long period stacking ordered(LPSO) phases are formed in Mg matrix of the as-cast alloy when rational design of alloy composition was employed, i.e.(Er + Y): Zn = 3:1 and Er: Y = 1: 1(at.%). It is worth mentioning that it is the first report regarding the formation of nano-spaced basal plane SFs throughout both DRXed and un-DRXed grains in as-extruded alloy with well-designed compositions and processing parameters. The results provide new opportunities to the development of deformed Mg alloys with satisfactory mechanical performance for high-temperature services. | Mingquan Zhang Yan Feng Jinghuai Zhang Shujuan Liu Qiang Yang Zhuang Liu Rongguang Li Jian Meng Ruizhi Wu | 2019 | Journal of Materials Science & Technology2019，35，10： | 5 |
| 9 | Development of high mechanical properties and moderate thermal conductivity cast Mg alloy with multiple RE via heat treatment显示文摘A new cast Mg–2 Gd–2 Nd–2 Y–1 Ho–1 Er–0.5 Zn–0.4 Zr(wt%) alloy was prepared by direct-chill semicontinuous casting technology. The microstructure, mechanical properties and thermal conductivity of the alloy in as-cast, solid-solution treated and especially peak-aged conditions were investigated. The as-cast alloy mainly consists of β-Mg matrix,(Mg, Zn)_3 RE phase and basal plane stacking faults. After proper solid-solution treatment, the microstructure becomes almost Mg-based single phase solid solution except just very few RE-riched particles. The as-cast and solid-solution treated alloys exhibit moderate tensile properties and thermal conductivity. It is noteworthy that the Mg alloy with 8 wt% multiple RE exhibits remarkable age-hardening response( HV = 35.7), which demonstrates that the multiple RE(RE = Gd, Nd, Y, Ho, Er) alloying instead of single Gd can effectively improve the age-hardening response.The peak-aged alloy has a relatively good combination of high strength/hardness(UTS(ultimate tensile strength) > 300 MPa; TYS(tensile yield strength) > 210 MPa; 115.3 HV), proper ductility(ε≈ 6%) and moderate thermal conductivity(52.5 W/(m K)). The relative mechanisms mainly involving aging precipitation of β￠ and β'' phases were discussed. The results provide a basis for development of high performance cast Mg alloys. | Guoqiang Li Jinghuai Zhang Ruizhi WU Yan Feng Shujuan Liu Xiaojun Wang Yufeng Jiao Qiang Yang Jian Meng | 2018 | Journal of Materials Science & Technology2018，34，7： | 4 |
| 10 | Using irrigation intervals to optimize water-use efficiency and maize yield in Xinjiang,northwest China显示文摘Worldwide, scarce water resources and substantial food demands require efficient water use and high yield.This study investigated whether irrigation frequency can be used to adjust soil moisture to increase grain yield and water use efficiency(WUE) of high-yield maize under conditions of mulching and drip irrigation.A field experiment was conducted using three irrigation intervals in 2016: 6, 9, and 12 days(labeled D6, D9, and D12) and five irrigation intervals in 2017: 3, 6, 9, 12, and 15 days(D3, D6, D9, D12, and D15).In Xinjiang, an optimal irrigation quota is 540 mm for high-yield maize.The D3, D6, D9, D12, and D15 irrigation intervals gave grain yields of 19.7, 19.1–21.0, 18.8–20.0, 18.2–19.2, and 17.2 Mg ha^-1 and a WUE of 2.48, 2.53–2.80, 2.47–2.63, 2.34–2.45, and 2.08 kg m-3, respectively.Treatment D6 led to the highest soil water storage, but evapotranspiration and soil-water evaporation were lower than other treatments.These results show that irrigation interval D6 can help maintain a favorable soil-moisture environment in the upper-60-cm soil layer, reduce soilwater evaporation and evapotranspiration, and produce the highest yield and WUE.In this arid region and in other regions with similar soil and climate conditions, a similar irrigation interval would thus be beneficial for adjusting soil moisture to increase maize yield and WUE under conditions of mulching and drip irrigation. | Guoqiang Zhang Dongping Shen Bo Ming Ruizhi Xie Xiuliang Jin Chaowei Liu Peng Hou Jun Xue Jianglu Chen Wanxu Zhang Wanmao Liu Keru Wang Shaokun Li | 2019 | The Crop Journal2019，7，3： | 4 |
| 11 | Silver nanocrystals sensitize magnetic-nanoparticle-mediated thermo-induced killing of cancer cells显示文摘磁性的 nanoparticles (MNP ) 能加热肿瘤纸巾起来并且导致在外部交流磁场下面癌症房间杀死。然而,磁性的 nanoparticles 过高热(MNPH ) 要求被注入肿瘤以便因为复杂的热转移,在 vivo 和 MNP 的有限的热质量获得临床上需要的热剂量的 MNP 的高集中。为了切,击倒 MNP 的剂量并且提高这 Nanotherapy 的效果,我们与不同尺寸准备了银 nanoparticles (AgNPs ) 并且在 MNPH 治疗在癌症房间上调查了这些 AgNPs 的效果。AgNPs 能提高 glioma 房间的 thermo 敏感,这效果是尺寸依赖者,这被发现。AgNPs 能导致在 G2/M 阶段逮捕并且在过高热以后提高了癌症房间的 apoptosis 率的房间周期。在适用的老鼠建模的 glioma,与 AgNPs 相结合的 MNPH 能在癌症房间提高 Bax 表示。我们的结果建议 AgNPs 能是潜在的 thermo 敏化并且能进一步为 MNPH 治疗为 Ag 基于 nanostructure 的热种子的设计被开发。 | Lianke Liu Fang Ni Jianchao Zhang Xiaoli Jiang Xiang Lu Zhirui Guo Ruizhi Xu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 4 |
| 12 | Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets显示文摘Ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous study.This study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or VA.Dietary supplementation of VA significantly increased average daily gain(ADG)(P<0.05).Both FA and VA decreased serum levels of thiobarbituric acid reactive substances(TBARS),interlukin(IL)-1β,IL-2,IL-6,and tumor necrosis factor(TNF)-α(P<0.05),and enhanced the expression of tight junction protein oclaudin(P<0.05).Analysis of gut microbiota indicated that both FA and VA increased the Firmicutes/Bacteroidetes ratio alongside reducing the relative abundance of the Prevotellaceae family including Prevotella 9 and Prevotella 2 genera,but enriched the Lachoiraceaea family including the Lachnospiraceae FCS020 group(P<0.05).Moreover,VA reduced the relative abundance of Prevotella 7 and Prevotella 1 but enriched Lachnospira,Eubacterium eligens group,and Eubacterium xylanophilum group(P<0.05),while FA showed a limited effect on these genera.The results demonstrated that both VA and FA could alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota. | Ruizhi Hu Shusong Wu Baizhen Li Jijun Tan Jiahao Yan Ying Wang Zhiyi Tang Ming Liu Chenxing Fu Hongfu Zhang Jianhua He | 2022 | Animal Nutrition2022，，1： | 3 |
| 13 | Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic显示文摘The reactions between gatifloxacin(GFX) and various one-electron oxidants,such as ˙OH,N3˙,Br2˙ˉ,and SO4˙ˉ,have been studied by pulse radiolysis techniques.The GFX radical anion formed in the reaction of GFX with eaqˉ could either be protonated or deprotonated,and the absorption of GFX radical anion was located at 390 nm.The transient species produced by the reaction of GFX with ˙OH radical shows a broad band in the 380?600 nm region with a shoulder,while the oxidation by N3˙,SO4˙ˉ,and Br2˙ˉ results in an absorption band with λmax = 370 nm.At neutral condition(pH 7),the rate constants of GFX reacting with ˙OH,N3˙,Br2˙ˉ,SO4˙ˉ and eaqˉ are estimated to be 1.0 × 1010,3.1 × 109,2.8 × 109,3.0 × 109,and 1.8 × 1010 dm3 mol?1 s?1,respectively.From the pH dependence on the formation of electron adducts and on the rate constant of GFX with eaqˉ,the pKa of GFX radical anion is estimated to be 5.5 and 9.3. | LI HaiXia LIU YanCheng TANG RuiZhi ZHANG Peng FU HaiYing YAO SiDe WANG WenFeng | 2012 | Science China Chemistry2012，55，7： | 3 |
| 14 | Reducing maize yield gap by matching plant density and solar radiation显示文摘Yield gap exists because the current attained actual grain yield cannot yet achieve the estimated yield potential. Chinese high yield maize belt has a wide span from east to west which results in different solar radiations between different regions and thus different grain yields. We used multi-site experimental data, surveyed farmer yield data, the highest recorded yield data in the literatures, and simulations with Hybrid-Maize Model to assess the yield gap and tried to reduce the yield gap by matching the solar radiation and plant density. The maize belt was divided into five regions from east to west according to distribution of accumulated solar radiation. The results showed that there were more than 5.8 Mg ha^(–1) yield gaps between surveyed farmer yield and the yield potential in different regions of China from east to west, which just achieved less than 65% of the yield potential. By analyzing the multi-site density experimental data, we found that the accumulated solar radiation was significantly correlated to optimum plant density which is the density with the highest yield in the multi-site density experiment(y=0.09895 x–32.49, P<0.01), according to which the optimum plant densities in different regions from east to west were calculated. It showed that the optimum plant density could be increased by 60.0, 55.2, 47.3, 84.8, and 59.6% compared to the actual density, the grain yield could be increased by 20.2, 18.3, 10.9, 18.1, and 15.3% through increasing plant density, which could reduce the yield gaps of 33.7, 23.0, 13.4, 17.3, and 10.4% in R(region)-1, R-2, R-3, R-4, and R-5, respectively. This study indicates that matching maize plant density and solar radiation is an effective approach to reduce yield gaps in different regions of China. | LIU Guang-zhou LIU Wan-mao HOU Peng MING Bo YANG Yun-shan GUO Xiao-xia XIE Ruizhi WANG Ke-ru LI Shao-kun | 2021 | Journal of Integrative Agriculture2021，20，2： | 2 |
| 15 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 16 | Pulse radiolysis of sparfloxacin in neutral aqueous solution显示文摘 | LIU Yancheng LI Haixia CUI Rongrong TANG Ruizhi XU Yulie WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 17 | Pulse radiolysis and laser flash photolysis study of balofloxacin显示文摘 | XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 18 | Wave‑Shaped Piezoelectric Nanofber Membrane Nanogenerator for Acoustic Detection and Recognition显示文摘With the rapid development of internet of things and wearable electronics,how to conveniently power uncountable sensors remains a huge challenge.Energy harvesting strategy is suggested to collect and convert environmental energies into electrical energy.Thereinto,piezoelectric polymers are utilized as fexible harvesters to convert mechanical energy.The latter widely distributes in both our daily life and industrial environment.Intrinsic piezoelectric property further drives piezoelectric polymers to construct fexible self-powered strain sensors.However,relatively low piezoelectric performance restricts their application in detection and conversion of weak mechanical excitations.Herein,wave-shaped 3D piezoelectric device was fabricated by embossing electrospun polyvinylidene fuoride nanofbers.This 3D structured device presents better longitudinal and transverse piezoelectric performance than usual fat-type one.This wave-shaped piezoelectric device was developed for acoustic detection and recognition with a frequency resolution better than 0.1 Hz.This wave-shaped device was capable of frequency spectrum analyses of various sound sources from human and animals and well presents its potential for future wearable acoustic sensors and transducers. | Fan Xu Jiang Yang Ruizhi Dong Hanxiao Jiang Conghuan Wang Weilin Liu Zaixiu Jiang Xiaoqing Zhang Guodong Zhu | 2021 | Advanced Fiber Materials2021，3，6： | 2 |
| 19 | Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer's disease显示文摘Tau hyperphosphorylation is a main cause of neuronal loss in Alzheimer's disease,which can be caused by many factors,including oxidative stress.The multifunctional protein p62,which exists in neurofibrillary tangles and causes aggregation of hyperphosphorylated tau,not only serves as a receptor in selective autophagy,but also regulates oxidative stress.However,whether p62 partici-pates in oxidative stress-induced tau hyperphosphorylation remains unclear.In this study,we pro-duced an Alzheimer's disease rat model by injecting β-amyloid protein into the hippocampus and β-galactose intraperitoneally.Hematoxylin-eosin staining was used for morphological analysis of brain tissue,and western blotting,immunohistochemistry and reverse transcription-PCR were em-ployed to study p62 and autophagy related proteins,antioxidant defense system kelch-like ECH-associated protein 1-NF-E2-related factor 2 related proteins and hyperphosphorylated tau,respectively.The number of neurons in the brain decreased in Alzheimer's disease rats,and the autophagy related proteins Atg12-Atg5,microtubule-associated protein 1 light chain 3-phosphatidylethanolamine and Beclin1 increased significantly,while p62 expression reduced.Expression of kelch-like ECH-associated protein 1 increased,NF-E2-related factor 2 protein and the downstream gene products of glutamate cysteine ligase catalytic subunit and glutamate cysteine ligase modulatory subunit decreased,and hyperphosphorylated tau increased.These findings demonstrate that autophagy levels increased and p62 levels decreased in the brains of Alzheimer's disease rats.Moreover,the anti-oxidative capability of the NF-E2-related factor 2-antioxidant re-sponse element pathway was decreased,which may be the cause of tau hyperphosphorylation in Alzheimer's disease brain tissue and the subsequent structural and functional damage to neurons. | Xianhong Zheng Weiwei Wang Ruizhi Liu Honglan Huang Rihui Zhang Liankun Sun | 2012 | Neural Regeneration Research2012，7，17： | 2 |
| 20 | Designing new low alloyed Mg-RE alloys with high strength and ductility via high-speed extrusion显示文摘Two new low-alloyed Mg-2RE-0.8Mn-0.6Ca-0.5Zn(wt%,RE=Sm or Y)alloys are developed,which can be produced on an in-dustrial scale via relatively high-speed extrusion.These two alloys are not only comparable to commercial AZ31 alloy in extrudability,but also have superior mechanical properties,especially in terms of yield strength(YS).The excellent extrudability is related to less coarse second-phase particles and high initial melting point of the two as-cast alloys.The high strength-ductility mainly comes from the formation of fine grains,nano-spaced submicron/nano precipitates,and weak texture.Moreover,it is worth noting that the YS of the two alloys can maintain above 160 MPa at elevated temperature of 250°C,significantly higher than that of AZ31 alloy(YS:45 MPa).The Zn/Ca solute segregation at grain boundaries,the improved heat resistance of matrix due to addition of RE,and the high melting points of strengthening particles(Mn,MgZn_(2),and Mg-Zn-RE/Mg-Zn-RE-Ca)are mainly responsible for the excellent high-temperature strength. | Jinshu Xie Zhi Zhang Shujuan Liu Jinghuai Zhang Jun Wang Yuying He Liwei Lu Yunlei Jiao Ruizhi Wu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 2 |
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